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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/21 17:06:37」(JST)

Leukotriene A4 is a leukotriene.

Leukotriene A4 hydrolase converts it to Leukotriene B4. Leukotriene C4 synthase converts it to Leukotriene C4.

Eicosanoid synthesis. (Leukotrienes at right.)

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Guriec N1, Le Jossic-Corcos C2, Simon B2, Ianotto JC3, Tempescul A3, Dréano Y2, Salaün JP2, Berthou C4, Corcos L2.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Nov;1842(11):2096-105. doi: 10.1016/j.bbadis.2014.07.016. Epub 2014 Jul 26.
Deregulation of the oxidative cascade of poly-unsaturated fatty acids (PUFAs) has been associated with several cancers, including chronic lymphocytic leukemia (B-CLL). Leukotriene B4 (LTB4), a metabolite of arachidonic acid (AA), is produced by B-CLL and contributes to their survival. The aim of the
PMID 25072959

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway.

Fredman G1, Ozcan L2, Spolitu S2, Hellmann J3, Spite M3, Backs J4, Tabas I1.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Oct 7;111(40):14530-5. doi: 10.1073/pnas.1410851111. Epub 2014 Sep 22.
Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of pr
PMID 25246560

Pro- and anti-inflammatory mediators change leukotriene B4 and leukotriene C4 synthesis and secretion in an inflamed porcine endometrium.

Czarzasta J1, Andronowska A1, Jana B2.
Domestic animal endocrinology.Domest Anim Endocrinol.2014 Oct;49:49-59. doi: 10.1016/j.domaniend.2014.05.001. Epub 2014 May 21.
We studied the effect of lipopolysaccharide (LPS), proinflammatory cytokines (tumor necrosis factor α [TNF-α] and interleukin [IL]-1β), and anti-inflammatory cytokines (IL-4 and IL-10) on leukotriene (LT) A4 hydrolase and LTC4 synthase (LTCS) protein expression in, and LTB4 and LTC4 secretion fro
PMID 25010026

Purification and Characterization of Porcine Skeletal Muscle Aminopeptidase T, a Novel Metallopeptidase Homologous to Leukotriene A_4 Hydrolase

Sarker Mohammed Alamgir,Matsuda Shinji,Mizutani Osamu [他],RAO Shengbin,MIGITA Koshiro,GOTO YAMAMOTO Nami,IEFUJI Haruyuki,NISHIMURA Toshihide
Bioscience, biotechnology, and biochemistry 75(6), 1154-1159, 2011-06-23
A novel aminopeptidase, Aminopeptidase T (APase T), was purified from porcine skeletal muscle following successive column chromatography: twice on DEAE-cellulose, hydroxyapatite, and Sephacryl S-200 H …
NAID 10029328354

Noguchi Koichi,Okubo Masamichi
Biological and Pharmaceutical Bulletin 34(8), 1163-1169, 2011
… We found the expression of 5-lipoxygenase (5-LO), FLAP and the cysteinyl leukotrienes (CysLT1) mRNAs in spinal microglia, LTA4h and LTC4s mRNAs in both spinal neurons and microglia, and BLT1 mRNA in spinal neurons. …
NAID 130000936581

Role of Leukotriene B4 in 5-Lipoxygenase Metabolite- and Allergy-Induced Itch-Associated Responses in Mice

Tsuji Fumio,Aono Hiroyuki,Tsuboi Takashi [他],Murakami Tadahiro,Enomoto Hiroshi,Mizutani Keiko,Inagaki Naoki
Biological and Pharmaceutical Bulletin 33(6), 1050-1053, 2010
… We investigated the role of leukotriene (LT) B4 in 5-lipoxygenase metabolite- and allergy-induced itch-associated responses using SA6541, an LTA4 hydrolase inhibitor. … By screening molecules related to arachidonic acid metabolism or pruritus, SA6541 was found to be a specific inhibiter of LTA4 hydrolase. …
NAID 130000247978

リンク元	「ロイコトリエン」「leukotriene A4」「ロイコトリエンA4」
関連記事	「LT」「LTA」

Leukotriene A4
Names
	IUPAC name 4-{(2S,3S)-3-[(1E,3E,5Z,8Z)-1,3,5,8-Tetradecatetraen-1-yl]-2-oxiranyl}butanoic acid
	Systematic IUPAC name 4-{(2S,3S)-3-[(1E,3E,5Z,8Z)-1,3,5,8-Tetradecatetraen-1-yl]-2-oxiranyl}butanoic acid
Identifiers
CAS Registry Number	72059-45-1
ChEBI	CHEBI:15651
ChemSpider	4444074
	InChI InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 ; Key: UFPQIRYSPUYQHK-WAQVJNLQSA-N ; InChI=1/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1; Key: UFPQIRYSPUYQHK-WAQVJNLQBZ ;
Jmol-3D images	Image
KEGG	C00909
MeSH	D017572
PubChem	5280383
	SMILES CCCCC/C=C\C/C=C\C=C\C=C\[C@H]1[C@@H](O1)CCCC(=O)O ;
Properties
Chemical formula	C20H30O3
Molar mass	318.450
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references

白血球遊走

気管支平滑筋収縮、細動脈収縮、血管透過性亢進

ロイコトリエンA₄	ロイコトリエンB₄とロイコトリエンC₄の前駆物質
ロイコトリエンB₄	chemotaxis
ロイコトリエンC₄	気管支収縮、血管拡張、血管透過性亢進、ロイコトリエンD₄の前駆物質
ロイコトリエンD₄	気管支収縮、血管拡張、血管透過性亢進、ロイコトリエンE₄の前駆物質
ロイコトリエンE₄	気管支収縮、血管拡張、血管透過性亢進