- 同
- LBP
- 同
- LBP
WordNet
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- a long-playing phonograph record; designed to be played at 33.3 rpm (同)L-P
- the 12th letter of the Roman alphabet (同)l
PrepTutorEJDIC
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- 蛋白(たんばく)質
- エルピーレコード(1分間331/3回転のレコード;商標名)
- lira(イタリアの貨幣単位リラ)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/08 19:18:22」(JST)
[Wiki en表示]
Lipopolysaccharide binding protein |
Identifiers |
Symbols |
LBP ; BPIFD2 |
External IDs |
OMIM: 151990 MGI: 1098776 HomoloGene: 3055 GeneCards: LBP Gene |
Gene ontology |
Molecular function |
• lipopolysaccharide binding
• receptor binding
• protein binding
• cell surface binding
• Gram-negative bacterial cell surface binding
• Gram-positive bacterial cell surface binding
• lipoteichoic acid binding
|
Cellular component |
• extracellular region
• extracellular space
|
Biological process |
• toll-like receptor signaling pathway
• leukocyte chemotaxis involved in inflammatory response
• macrophage activation involved in immune response
• acute-phase response
• cellular defense response
• opsonization
• lipopolysaccharide transport
• lipopolysaccharide-mediated signaling pathway
• detection of molecule of bacterial origin
• response to lipopolysaccharide
• negative regulation of tumor necrosis factor production
• positive regulation of chemokine production
• positive regulation of interleukin-6 production
• positive regulation of interleukin-8 production
• positive regulation of tumor necrosis factor production
• toll-like receptor 4 signaling pathway
• positive regulation of toll-like receptor 4 signaling pathway
• positive regulation of tumor necrosis factor biosynthetic process
• positive regulation of macrophage activation
• negative regulation of growth of symbiont in host
• innate immune response
• defense response to Gram-negative bacterium
• defense response to Gram-positive bacterium
• positive regulation of respiratory burst involved in inflammatory response
• cellular response to lipopolysaccharide
• cellular response to lipoteichoic acid
• positive regulation of neutrophil chemotaxis
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
|
Entrez |
3929 |
16803 |
|
Ensembl |
ENSG00000129988 |
ENSMUSG00000016024 |
|
UniProt |
P18428 |
Q61805 |
|
RefSeq (mRNA) |
NM_004139 |
NM_008489 |
|
RefSeq (protein) |
NP_004130 |
NP_032515 |
|
Location (UCSC) |
Chr 20:
36.97 – 37.01 Mb |
Chr 2:
158.31 – 158.33 Mb |
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PubMed search |
[1] |
[2] |
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Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP gene.[1][2]
LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4.[3]
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.[2]
Contents
- 1 Interactions
- 2 References
- 3 Further reading
- 4 External links
Interactions
Lipopolysaccharide-binding protein has been shown to interact with CD14, TLR2, TLR4 and the co-receptor MD-2.[4][5][6]
References
- ^ Gray PW, Corcorran AE, Eddy RL Jr, Byers MG, Shows TB (March 1993). "The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20". Genomics 15 (1): 188–90. doi:10.1006/geno.1993.1030. PMID 8432532.
- ^ a b "Entrez Gene: LBP lipopolysaccharide binding protein".
- ^ Muta T, Takeshige K (2001). "Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations". Eur. J. Biochem. 268 (16): 4580–9. doi:10.1046/j.1432-1327.2001.02385.x. PMID 11502220.
- ^ Thomas, Celestine J; Kapoor Mili, Sharma Shilpi, Bausinger Huguette, Zyilan Umit, Lipsker Dan, Hanau Daniel, Surolia Avadhesha (November 2002). "Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response". FEBS Lett. (Netherlands) 531 (2): 184–8. doi:10.1016/S0014-5793(02)03499-3. ISSN 0014-5793. PMID 12417309.
- ^ Yu, B; Wright S D (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14". J. Inflamm. (UNITED STATES) 45 (2): 115–25. ISSN 1078-7852. PMID 7583357.
- ^ Erridge, C; Pridmore, A; Eley, A; Stewart, J; Poxton, IR (2004). "Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2.". Journal of Medical Microbiology 53 (Pt 8): 735–40. doi:10.1099/jmm.0.45598-0. PMID 15272059.
Further reading
- Schumann RR, Leong SR, Flaggs GW, et al. (1990). "Structure and function of lipopolysaccharide binding protein.". Science 249 (4975): 1429–31. doi:10.1126/science.2402637. PMID 2402637.
- Wilde CG, Seilhamer JJ, McGrogan M, et al. (1994). "Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation.". J. Biol. Chem. 269 (26): 17411–6. PMID 7517398.
- Park CT, Wright SD (1996). "Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins.". J. Biol. Chem. 271 (30): 18054–60. doi:10.1074/jbc.271.30.18054. PMID 8663389.
- Nanbo A, Nishimura H, Nagasawa S (1997). "Lipopolysaccharide binding protein from normal human plasma purified with high efficiency.". Protein Expr. Purif. 10 (1): 55–60. doi:10.1006/prep.1996.0712. PMID 9179291.
- Hubacek JA, Büchler C, Aslanidis C, Schmitz G (1997). "The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved.". Biochem. Biophys. Res. Commun. 236 (2): 427–30. doi:10.1006/bbrc.1997.6970. PMID 9240454.
- Jack RS, Fan X, Bernheiden M, et al. (1997). "Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection.". Nature 389 (6652): 742–5. doi:10.1038/39622. PMID 9338787.
- Kirschning CJ, Au-Young J, Lamping N, et al. (1998). "Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins.". Genomics 46 (3): 416–25. doi:10.1006/geno.1997.5030. PMID 9441745.
- Beamer LJ, Carroll SF, Eisenberg D (1998). "The BPI/LBP family of proteins: a structural analysis of conserved regions". Protein Sci. 7 (4): 906–14. doi:10.1002/pro.5560070408. PMC 2143972. PMID 9568897.
- Sato M, Saeki Y, Tanaka K, Kaneda Y (1999). "Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system". Biochem. Biophys. Res. Commun. 256 (2): 385–90. doi:10.1006/bbrc.1999.0343. PMID 10079194.
- Vreugdenhil AC, Dentener MA, Snoek AM, et al. (1999). "Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response". Journal of Immunology 163 (5): 2792–8. PMID 10453023.
- Vesy CJ, Kitchens RL, Wolfbauer G, et al. (2000). "Lipopolysaccharide-Binding Protein and Phospholipid Transfer Protein Release Lipopolysaccharides from Gram-Negative Bacterial Membranes". Infect. Immun. 68 (5): 2410–7. doi:10.1128/IAI.68.5.2410-2417.2000. PMC 97439. PMID 10768924.
- Labéta MO, Vidal K, Nores JE, et al. (2000). "Innate Recognition of Bacteria in Human Milk Is Mediated by a Milk-Derived Highly Expressed Pattern Recognition Receptor, Soluble Cd14". J. Exp. Med. 191 (10): 1807–12. doi:10.1084/jem.191.10.1807. PMC 2193148. PMID 10811873.
- Dentener MA, Vreugdenhil AC, Hoet PH, et al. (2000). "Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins". Am. J. Respir. Cell Mol. Biol. 23 (2): 146–53. PMID 10919979.
- Nagaoka I, Hirota S, Niyonsaba F, et al. (2001). "Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells". Journal of Immunology 167 (6): 3329–38. PMID 11544322.
- Gutsmann T, Müller M, Carroll SF, et al. (2001). "Dual Role of Lipopolysaccharide (LPS)-Binding Protein in Neutralization of LPS and Enhancement of LPS-Induced Activation of Mononuclear Cells". Infect. Immun. 69 (11): 6942–50. doi:10.1128/IAI.69.11.6942-6950.2001. PMC 100074. PMID 11598069.
- Iovine N, Eastvold J, Elsbach P, et al. (2002). "The carboxyl-terminal domain of closely related endotoxin-binding proteins determines the target of protein-lipopolysaccharide complexes". J. Biol. Chem. 277 (10): 7970–8. doi:10.1074/jbc.M109622200. PMID 11773072.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Kaden J, Zwerenz P, Lambrecht HG, Dostatni R (2002). "Lipopolysaccharide-binding protein as a new and reliable infection marker after kidney transplantation". Transpl. Int. 15 (4): 163–72. doi:10.1007/s00147-002-0392-2. PMID 11976738.
- Reyes O, Vallespi MG, Garay HE, et al. (2002). "Identification of single amino acid residues essential for the binding of lipopolysaccharide (LPS) to LPS binding protein (LBP) residues 86-99 by using an Ala-scanning library". J. Pept. Sci. 8 (4): 144–50. doi:10.1002/psc.375. PMID 11991204.
External links
- lipopolysaccharide-binding protein at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Signaling pathway: TLR signaling pathway
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Receptor |
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Other external |
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Internal |
- adaptor: MYD88
- TRIF
- TIRAP
- TRAF6
- TOLLIP
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Bacterial endotoxin and non-alcoholic fatty liver disease in the general population: a prospective cohort study.
- Wong VW1,2,3, Wong GL1,2,3, Chan HY1,2,3, Yeung DK4, Chan RS1,5, Chim AM1,2,3, Chan CK1,2,3, Tse YK1,2, Woo J1,5, Chu WC2,6, Chan HL1,2,3.
- Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2015 Sep;42(6):731-40. doi: 10.1111/apt.13327. Epub 2015 Jul 23.
- BACKGROUND: Patients with non-alcoholic steatohepatitis (NASH) have increased intestinal permeability and small intestine bacterial overgrowth.AIMS: To test the hypothesis that endotoxemia is associated with non-alcoholic fatty liver disease (NAFLD) in the general population, and to study dietary fa
- PMID 26202818
- Cloning and characterization of two lipopolysaccharide-binding protein/bactericidal permeability-increasing protein (LBP/BPI) genes from the sea cucumber Apostichopus japonicus with diversified function in modulating ROS production.
- Shao Y1, Li C2, Che Z1, Zhang P1, Zhang W1, Duan X1, Li Y1.
- Developmental and comparative immunology.Dev Comp Immunol.2015 Sep;52(1):88-97. doi: 10.1016/j.dci.2015.04.015. Epub 2015 May 5.
- Lipopolysaccharide-binding protein and bactericidal permeability-increasing protein (LBP/BPI) play crucial role in modulating cellular signals in response to Gram-negative bacteria infection. In the present study, two isoforms of LBP/BPI genes (designated as AjLBP/BPI1 and AjLBP/BPI2, respectively)
- PMID 25956196
- Postprandial Endotoxemia Linked With Chylomicrons and Lipopolysaccharides Handling in Obese Versus Lean Men: A Lipid Dose-Effect Trial.
- Vors C1, Pineau G1, Drai J1, Meugnier E1, Pesenti S1, Laville M1, Laugerette F1, Malpuech-Brugère C1, Vidal H1, Michalski MC1.
- The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2015 Sep;100(9):3427-35. doi: 10.1210/JC.2015-2518. Epub 2015 Jul 7.
- CONTEXT: Postprandial endotoxemia is a metabolic risk factor, which has been shown to originate from the intestinal absorption of gut lipopolysaccharides (LPS) using nonphysiological high-fat tests.OBJECTIVE: This study aimed to determine whether different realistic fat amounts can modulate postpran
- PMID 26151336
Japanese Journal
- Chaetoglobosin Fex from the Marine-Derived Endophytic Fungus Inhibits Induction of Inflammatory Mediators via Toll-Like Receptor 4 Signaling in Macrophages
- Cyclic Limulus Anti-lipopolysaccharide (LPS) Factor-Derived Peptide CLP-19 Antagonizes LPS Function by Blocking Binding to LPS Binding Protein
- Levels of Soluble CD14 and Lipopolysaccharide-Binding Protein in Human Basal Tears
Related Links
- 第1回 リポ多糖(Lipopolysaccharide; LPS)は内毒素か外因性ホルモンか? はじめに 生物は環境から多くの情報(刺激・ストレス)を受け取り、環境に適合しながら生活している。環境の一つとして、常在している細菌叢が近年健康との関係で ...
- GoPubMed lists recent and important papers and reviews for lipopolysaccharide binding protein(LPS-binding protein) ... The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial ...
Related Pictures
★リンクテーブル★
[★]
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
[★]
- 関
- BP、carrier protein、transport protein
[★]
[★]
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リポ多糖 lipopolysaccharide