関: CD2

関: CD2

WordNet

the 12th letter of the Roman alphabet (同)l

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lira(イタリアの貨幣単位リラ)
low frequency

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/08 17:23:07」(JST)

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CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2,^[1] LFA-3 receptor, erythrocyte receptor and rosette receptor.^[2]

Function

It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.^[3]

In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.^[4]

Diagnostic relevance

CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms.^[5]

Classification

Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.^[4]

Interactions

CD2 has been shown to interact with CD2BP2,^[6] Lck^[7] and PSTPIP1.^[8]

References

^ Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA (1982). "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3". Proc Natl Acad Sci U S A 79 (23): 7489–93. doi:10.1073/pnas.79.23.7489. PMC 347365. PMID 6984191.
^ Uniprot database entry for CD2 (accession number P06729)
^ Wilkins AL, Yang W, Yang JJ (2003). "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design". Curr Protein Pept Sci 4 (5): 367–73. doi:10.2174/1389203033487063. PMID 14529530.
^ ^a ^b Yang JJ, Ye Y, Carroll A, Yang W, Lee HW (2001). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation". Curr Protein Pept Sci 2 (1): 1–17. doi:10.2174/1389203013381251. PMID 12369898.
^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 61. ISBN 1-84110-100-1.
^ Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (December 1998). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14897–902. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.
^ Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB (January 1996). "The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2". J. Exp. Med. 183 (1): 169–78. doi:10.1084/jem.183.1.169. PMC 2192399. PMID 8551220.
^ Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (December 1998). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.

External links

CD2 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart

UpToDate Contents

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1. 臨床的腎移植における研究中の免疫抑制剤およびそのアプローチ investigational immunosuppressive drugs and approaches in clinical kidney transplantation
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5. 冠動脈疾患患者における脂質低下薬の利益の機序 mechanisms of benefit of lipid lowering drugs in patients with coronary heart disease

English Journal

CD4-positive diffuse large B-cell lymphoma: A variant with aggressive clinical potential.

Hussaini MO1, Kreisel FH1, Hassan A1, Nguyen TT1, Frater JL1.
World journal of methodology.World J Methodol.2016 Sep 26;6(3):181-6. doi: 10.5662/wjm.v6.i3.181. eCollection 2016.
CD4 expression is rare in diffuse large B-cell lymphoma (DLBCL), with 4 previously reported cases. Its significance is uncertain. We report five patients with CD4(+) DLBCL and one CD4(+) primary mediastinal large B-cell lymphoma. Cases were identified by searching the electronic database of the depa
PMID 27679780

A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis.

Koumakis E1, Bouaziz M2, Dieudé P3, Cauvet A4, Ruiz B4, Airò P5, Cusi D6, Matucci-Cerinic M7, Salvi E8, Cuomo G9, Hachulla E10, Diot E11, Caramaschi P12, Riccieri V13, Avouac J1, Allanore Y14.
Clinical and experimental rheumatology.Clin Exp Rheumatol.2016 Sep-Oct;34 Suppl 100(5):43-48. Epub 2016 Jul 1.
OBJECTIVES: Systemic sclerosis (SSc) is a rare autoimmune disease (AID) with a complex genetic etiology. Evidence for a shared pathogenesis across AIDs is given by the well-known pleiotropism of autoimmune genes. Recently, several unbiased approaches have identified an association between polymorphi
PMID 27385538

Expression of TIA1 and PAX5 in Classical Hodgkin Lymphoma at Initial Diagnosis May Predict Clinical Outcome.

Nguyen TT1, Frater JL, Klein J, Chen L, Bartlett NL, Foyil KV, Kreisel FH.
Applied immunohistochemistry & molecular morphology : AIMM.Appl Immunohistochem Mol Morphol.2016 Jul;24(6):383-91. doi: 10.1097/PAI.0000000000000200.
Although the expression of T-cell antigens and proteins associated with tumor-infiltrating T-lymphocytes (TILs), regulatory T cells (T-regs), and B-cell development have been evaluated in classical Hodgkin lymphoma (cHL), few studies correlate these proteins' expression patterns with clinical outcom
PMID 26067141

Japanese Journal

Three distinct antigens associated with human T lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3

Proc. Natl. Acad. Sci. USA 79, 7489, 1982
NAID 30016273603

Related Pictures

★リンクテーブル★

リンク元	「接着分子」「CD2」
関連記事	「LF」「L」「LFA」

「接着分子」

CD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I
Identifiers
Aliases	CD2, LFA-2, SRBC, T11, CD2 molecule
External IDs	OMIM: 186990 MGI: 88320 HomoloGene: 1338 GeneCards: 914
Gene ontology
Molecular function	• protein homodimerization activity; • protein binding; • receptor binding; • receptor activity;
Cellular component	• integral component of membrane; • membrane; • cell-cell junction; • anchored component of plasma membrane; • plasma membrane; • integral component of plasma membrane; • extracellular region; • cell surface; • cytoplasmic side of plasma membrane; • external side of plasma membrane;
Biological process	• single organismal cell-cell adhesion; • positive regulation of myeloid dendritic cell activation; • heterotypic cell-cell adhesion; • natural killer cell activation; • blood coagulation; • membrane raft polarization; • cell surface receptor signaling pathway; • cell adhesion; • positive regulation of interferon-gamma secretion; • positive regulation of tumor necrosis factor production; • positive regulation of interleukin-8 secretion; • T cell activation; • leukocyte migration; • regulation of T cell differentiation; • apoptotic process;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	914
	12481
	ENSG00000116824
	ENSMUSG00000027863
	P06729; Q53F96
	P08920
	NM_001767
	NM_013486
	NP_001758.2; NP_001758.2
	NP_038514.1
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: adhesion molecule
同: 接着因子
関

接着分子のファミリー

インテグリンファミリー
Igスーパーファミリー
セレクチンファミリー
CD44ファミリー
カドヘリンファミリー

白血球の相互作用に関与している接着分子 (IMM.87)

グループ名	機能	名称	別名		組織分布	リガンド
セレクチン	炭化水素鎖に結合。白血球-内皮細胞の反応を開始	P-selectin	PADGEN	CD62P	活性化した内皮細胞、活性化した血小板	PSGL-1, sialyl-Lewisx
セレクチン	炭化水素鎖に結合。白血球-内皮細胞の反応を開始	E-selectin	ELAM-1	CD62E	活性化した内皮細胞	sialyl-Lewisx
インテグリン	CAMや細胞外マトリックスに結合。強い結合	LFA-1	αL:β2	CD11a:CD18	単球、T細胞、マクロファージ、好中球、樹状細胞	ICAMs
		CR3, Mac-1	αM:β2	CD11b:CD18	好中球、単球、マクロファージ	ICAM-1, iC3b, fibrinogen
		CR4, p150.95	αX:β2	CD11c:CD18	樹状細胞、マクロファージ、好中球	iC3b
		VLA-5	α5:β1	CD49d:CD29	単球、マクロファージ	fibronectin
免疫グロブリンスーパーファミリー	細胞結合で様々に働く。インテグリンの基質	ICAM-1		CD54	活性化した内皮細胞	LFA-1, MAC1
		ICAM-2		CD102	非活性化状態の内皮細胞、樹状細胞	LFA-1
		VCAM-1		CD106	活性化した内皮細胞	VLA-4
		PECAM		CD31	活性化した白血球、内皮細胞間の結合	CD31

白血球の相互作用に関与している免疫グロブリンスーパーファミリーの接着分子 (IMM.329)

名称		分布組織	リガンド
CD2	LFA-2	T細胞	LFA-1	CD53
ICAM-1	CD54	活性化した血管、リンパ球、樹状細胞	LFA-1, Mac-1
ICAM-2	CD102	非活性化状態の血管	LFA-1
ICAM-3	CD50	Naive T cells	DC-SIGN, LFA-1
LFA-3	CD58	リンパ球、APC	CD2
VCAM-1	CD106	活性化した内皮細胞	VLA-4

-接着分子

-細胞接着分子

-カドヘリン

「CD2」

　　[★]

同: Leucine-5, SRBC receptor, LFA-2
関: CD

発現細胞

T細胞、胸腺細胞、NK細胞

分子量

45-58

機能

接着分子、CD58(LFA-3)に結合。細胞内部でLckに結合し、T細胞を活性化

リンパ球が抗原提示細胞と相互作用するのに重要 (IMM.343)

別名

LFA-2, T11

ファミリー

immunoglobulin

「LF」

　　[★]

「L」

　　[★]

「LFA」

　　[★] リンパ球機能関連抗原

[1] Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA (1982). "Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3". Proc Natl Acad Sci U S A 79 (23): 7489–93. doi:10.1073/pnas.79.23.7489. PMC 347365. PMID 6984191.

[2] Uniprot database entry for CD2 (accession number P06729)

[3] Wilkins AL, Yang W, Yang JJ (2003). "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design". Curr Protein Pept Sci 4 (5): 367–73. doi:10.2174/1389203033487063. PMID 14529530.

[yang-4] Yang JJ, Ye Y, Carroll A, Yang W, Lee HW (2001). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation". Curr Protein Pept Sci 2 (1): 1–17. doi:10.2174/1389203013381251. PMID 12369898.

[Leong-5] Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 61. ISBN 1-84110-100-1.

[pmid9843987-6] Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (December 1998). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14897–902. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.

[pmid8551220-7] Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB (January 1996). "The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2". J. Exp. Med. 183 (1): 169–78. doi:10.1084/jem.183.1.169. PMC 2192399. PMID 8551220.

[pmid9857189-8] Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (December 1998). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.

匿名

検索

案内

案内

LFA-2