L1

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/12/09 19:52:56」(JST)

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英文文献

  • Self-nanoemulsifying performance of two grades of Lauroglycol (Lauroglycol-90 and Lauroglycol-FCC) in the presence of mixed nonionic surfactants.
  • Shakeel F1, Haq N, Alanazi FK, Alsarra IA.Author information 1Center of Excellence in Biotechnology Research, King Saud University , P.O. Box 2460, Riyadh 11451 , Saudi Arabia .AbstractThe present study was undertaken to evaluate the impact of various combinations of nonionic surfactants on self-nanoemulsifying performance of two grades of Lauroglycol (Lauroglycol-90 and Lauroglycol-FCC) in glibenclamide (GBN) nanoemulsion. Formulations (L1-L30) were prepared by spontaneous emulsification method. Prepared formulations were subjected to thermodynamic stability and self-nanoemulsification test. Results of thermodynamic stability and self-nanoemulsification tests were confirmed by further characterization of these formulations in terms of droplet size, viscosity, refractive index and % transmittance. Formulations prepared with Labrasol, HCO-60 and Gelucire-44/14 were found to be suitable for self-emulsifying drug delivery system only whereas those prepared with Tween-80 and Cremophor-EL were found to be suitable for self-nanoemulsifying or self-microemulsifying drug delivery system of GBN with respect to Lauroglycol-90 or Lauroglycol-FCC. Formulation L24 (Lauroglycol-FCC/Tween-80/ethanol/water) was optimized as best formulation for self-nanoemulsifying drug delivery system of GBN. These results indicated that Tween-80 could be the best surfactant in terms of self-nanoemulsification.
  • Pharmaceutical development and technology.Pharm Dev Technol.2014 Nov;19(7):799-805. doi: 10.3109/10837450.2013.829099. Epub 2013 Aug 22.
  • The present study was undertaken to evaluate the impact of various combinations of nonionic surfactants on self-nanoemulsifying performance of two grades of Lauroglycol (Lauroglycol-90 and Lauroglycol-FCC) in glibenclamide (GBN) nanoemulsion. Formulations (L1-L30) were prepared by spontaneous emulsi
  • PMID 23964928
  • Electrochemical detection of human papillomavirus DNA type 16 using a pyrrolidinyl peptide nucleic acid probe immobilized on screen-printed carbon electrodes.
  • Jampasa S1, Wonsawat W2, Rodthongkum N3, Siangproh W4, Yanatatsaneejit P5, Vilaivan T6, Chailapakul O7.Author information 1Program in Petrochemical and Polymer Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.2Department of Chemistry, Faculty of Science and Technology, Suan Sunandha Rajabhat University, 1 U-Thong Nok Road, Dusit, Bangkok 10300, Thailand.3Metallurgy and Materials Science Research Institute, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.4Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand.5Human Genetics Research Group, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.6Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.7Electrochemistry and Optical Spectroscopy Research Unit, Department of Chemistry, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand. Electronic address: corawon@chula.ac.th.AbstractAn electrochemical biosensor based on an immobilized anthraquinone-labeled pyrrolidinyl peptide nucleic acid (acpcPNA) probe was successfully developed for the selective detection of human papillomavirus (HPV) type 16 DNA. A 14-mer acpcPNA capture probe was designed to recognize a specific 14 nucleotide region of HPV type 16 L1 gene. The redox-active label anthraquinone (AQ) was covalently attached to the N-terminus of the acpcPNA probe through an amide bond. The probe was immobilized onto a chitosan-modified disposable screen-printed carbon electrode via a C-terminal lysine residue using glutaraldehyde as a cross-linking agent. Hybridization with the target DNA was studied by measuring the electrochemical signal response of the AQ label using square-wave voltammetric analysis. The calibration curve exhibited a linear range between 0.02 and 12.0 µM with a limit of detection and limit of quantitation of 4 and 14 nM, respectively. This DNA sensing platform was successfully applied to detect the HPV type 16 DNA from a PCR amplified (240 bp fragment of the L1 gene) sample derived from the HPV type 16 positive human cancer cell line (SiHa), and failed to detect the HPV-negative c33a cell line. The sensor probe exhibited very high selectivity for the complementary 14 base oligonucleotide over the non-complementary oligonucleotides with sequences derived from HPV types 18, 31 and 33. The proposed sensor provides an inexpensive tool for the early stage detection of HPV type 16, which is an important biomarker for cervical cancer.
  • Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:428-34. doi: 10.1016/j.bios.2013.11.023. Epub 2013 Nov 20.
  • An electrochemical biosensor based on an immobilized anthraquinone-labeled pyrrolidinyl peptide nucleic acid (acpcPNA) probe was successfully developed for the selective detection of human papillomavirus (HPV) type 16 DNA. A 14-mer acpcPNA capture probe was designed to recognize a specific 14 nucleo
  • PMID 24300785

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★リンクテーブル★
リンク元急性白血病」「第1腰椎
拡張検索L1 cell adhesion molecule」「neural cell adhesion molecule L1」「神経細胞接着分子L1」「RBL1
関連記事L

急性白血病」

  [★]

acute leukemia, AL
白血病FAB分類


概念

  • 未分化の白血球の腫瘍性増殖

分類

FAB分類

M0   minimally differentiated acute myeloblastic leukemia AML
M1   acute myeloblastic leukemia, without maturation
M2   acute myeloblastic leukemia, with granulocytic maturation
M3   promyelocytic, or acute promyelocytic leukemia APL
M4   急性骨髄単球性白血病 acute myelomonocytic leukemia AMMoL
M4eo   myelomonocytic together with bone marrow eosinophilia
M5 M5a 急性単芽球性白血病 acute monoblastic leukemia AMoL
M5b 急性単球性白血病 acute monocytic leukemia
M6 M6a 赤白血病 acute erythroid leukemias, including erythroleukemia  
M6b and very rare pure erythroid leukemia  
M7 急性巨核芽球性白血病 acute megakaryoblastic leukemia  
M8 急性好塩基球性白血病 acute basophilic leukemia  
L1 小細胞型    
L2 大細胞型    
L3 Burkitt型    

病態

  • 白血球系芽球の腫瘍性増殖
  • 骨髄機能障害
  • 腫瘍細胞の臓器浸潤
  • 腫瘍細胞の破壊亢進

徴候

  • 全身:息切れ、全身倦怠感、発熱(免疫力低下による感染症、腫瘍細胞の崩壊)
  • 皮膚:点状出血、紫斑
  • 口腔内:歯肉出血
  • 骨・関節:骨痛、関節痛  ← 腫瘍細胞の関節への浸潤
  • 肝臓・脾臓:肝脾腫
  • リンパ節:腫脹(頚部リンパ節、鼡径リンパ節)
  • 唾液腺:顎下唾液腺腫大

検査

  • 血算
  • 白血球:増加
  • 血小板:減少
  • 赤血球:減少 (正球性正色素性貧血)
  • 血液生化学
  • LDH↑
  • ビタミンB12↑
  • 尿酸↑

治療

小児

  • 化学療法:小児のALLでは著効する
  • 骨髄移植:小児のALLでは再発例に行う

成人

急性骨髄性白血病

急性前骨髄球性白血病

急性リンパ性白血病

VACAP

予後

小児急性白血病の予後不良因子

YN.G-44改変

小児急性白血病の予後不良因子

  • 1. 年齢:1歳以下、10歳以上
  • 2. 男児
  • 3. FAB分類L2, L3
  • 4. 非リンパ球性
  • 5. WBC:2万以上
  • 6. Ph染色体 t(9;22) (小児のALLの数%)

成人急性白血病の予後不良因子

YN.G-44改変

AMLの予後不良因子

  • 染色体核型、年齢、初発時白血球数、FAB分類、3系統の形態異常、二次性白血病
  • 染色体核型:最大の予後因子

NCCNガイドラインに基づくAMLの予後分類

参考1
  染色体核型 遺伝子異常
予後良好群 inv(16), t(8;21), t(15;17)(付加的染色体異常の有無を問わない) 正常核型におけるNPM1のみの異常
中間群 正常核型, +8, t(9;11),その他の予後良好にも不良にも属さない染色体異常 t(8;21), inv(16)患者におけるc-kit異常
予後不良群 複雑核型(3以上の異常), -5, -7, 5q-, 7q-,11q23異常(t(9;11)を除く), inv(3), t(3;3),t(6;9), t(9;22) 正常核型におけるFLT3-ITDのみの異常

参考

  • 1. 造血細胞移植ガイドライン - 急性骨髄性白血病
http://www.jshct.com/guideline/pdf/2009AML.pdf




第1腰椎」

  [★]

first lumbar vertebra, L1


L1 cell adhesion molecule」

  [★]

L1細胞接着分子

cell adhesion molecule L1L1CAMneural cell adhesion molecule L1


neural cell adhesion molecule L1」

  [★]

神経細胞接着分子L1

cell adhesion molecule L1L1 cell adhesion moleculeL1CAM


神経細胞接着分子L1」

  [★]

neural cell adhesion molecule L1
細胞接着分子L1L1細胞接着分子


RBL1」

  [★]



L」

  [★]

WordNet   license wordnet

「the 12th letter of the Roman alphabet」
l

PrepTutorEJDIC   license prepejdic

「lira(イタリアの貨幣単位リラ)」


"http://meddic.jp/L1" より作成


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