WordNet
- the 12th letter of the Roman alphabet (同)l
- a crystalline amino acid that occurs in many proteins
PrepTutorEJDIC
- lira(イタリアの貨幣単位リラ)
- liter[s]
UpToDate Contents
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- 1. 肝機能検査値異常が認められた患者に対するアプローチ approach to the patient with abnormal liver function tests
- 2. 肝疾患の有無と血漿中のアスパラギン酸アミノトランスフェラーゼおよびアラニン・
アミノトランスフェラーゼ濃度のパターン patterns of plasma aspartate and alanine aminotransferase levels with and without liver disease - 3. 小児および思春期の患者における アセトアミノフェン（パラセタモール）中毒の
臨床症状および診断 clinical manifestations and diagnosis of acetaminophen paracetamol poisoning in children and adolescents - 4. 肝細胞障害を検出する肝機能検査 liver function tests that detect injury to hepatocytes
- 5. 血清アミノトランスフェラーゼ値が正常な慢性C型肝炎ウイルス感染患者へのアプローチ approach to patients with chronic hepatitis c virus infection and normal serum aminotransferases
English Journal
- Protective role of probiotic lactic acid bacteria against dietary fumonisin B1-induced toxicity and DNA-fragmentation in sprague-dawley rats.
- Khalil AA1, Abou-Gabal AE, Abdellatef AA, Khalid AE.
- Preparative biochemistry & biotechnology.Prep Biochem Biotechnol.2015 Aug 18;45(6):530-50. doi: 10.1080/10826068.2014.940969.
- The genus Fusarium, especially F. verticillioides and F. proliferatum, has been found in several agricultural products worldwide, especially in maize. Regardless the occurrence of symptoms, the presence of Fusarium in maize constitutes an imminent risk due to its ability to produce fumonisins, mycot
- PMID 25036875
- Trihalomethane exposure and biomonitoring for the liver injury indicator, alanine aminotransferase, in the United States population (NHANES 1999-2006).
- Burch JB1, Everson TM2, Seth RK3, Wirth MD4, Chatterjee S5.
- The Science of the total environment.Sci Total Environ.2015 Jul 15;521-522:226-34. doi: 10.1016/j.scitotenv.2015.03.050. Epub 2015 Apr 2.
- Exposure to trihalomethanes (or THMs: chloroform, bromoform, bromodichloromethane, and dibromochloromethane [DBCM]) formed via drinking water disinfection has been associated with adverse reproductive outcomes and cancers of the digestive or genitourinary organs. However, few studies have examined p
- PMID 25847167
- Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
- Iida A1, Sasaki E1, Yano A1, Tsuneyama K1, Fukami T1, Nakajima M1, Yokoi T2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Jul;43(7):958-68. doi: 10.1124/dmd.115.063370. Epub 2015 Apr 13.
- Carbamazepine (CBZ) is widely used as an antiepileptic agent and causes rare but severe liver injury in humans. It has been generally recognized that reactive metabolites formed via the metabolic activation reaction contribute to the onset of liver injuries by several drugs. However, the role of CBZ
- PMID 25870103
Japanese Journal
- Isolation of a Mutant Auxotrophic for L-Alanine and Identification of Three Major Aminotransferases That Synthesize L-Alanine in Escherichia coli
- YONEYAMA Hiroshi,HORI Hatsuhiro,LIM Sang-Jo,MURATA Tatsuya,ANDO Tasuke,ISOGAI Emiko,KATSUMATA Ryoichi
- Bioscience, biotechnology, and biochemistry 75(5), 930-938, 2011-05-23
- … For Escherichia coli, it has been assumed that L-alanine is synthesized by alanine-valine transaminase (AvtA) in conjunction with an unknown alanine aminotransferase(s). … We isolated alanine auxotrophs from a prototrophic double mutant deficient in AvtA and YfbQ, a novel alanine aminotransferase, by chemical mutagenesis. …
- NAID 10028272693
- Benign Symmetric Lipomatosis: A Patient Report
- Tanji Yoshiyuki
- Yonago Acta medica 48(4), 101-106, 2005-12
- … This patient had consumed an excessive amount of alcohol with elevated liver enzymes including aspartate aminotransferase (133 IU/L), alanine aminotransferase (159 IU/L) and gamma-glutamyl transpeptidase (355 IU/L). …
- NAID 110003495518
Related Links
- alanine aminotransferase /al·a·nine ami·no·trans·fer·ase/ (ah-me″no-trans´fer-ās) alanine transaminase. alanine aminotransferase n. Abbr. ALT See SGPT. alanine aminotransferase (ALT), an enzyme normally present in the serum and ...
- ALT is increased with liver damage and is used to screen for and/or monitor liver disease. Alanine aminotransferase (ALT) is usually measured concurrently with AST as part of a liver function panel to determine the source of organ damage. [1] The reference range for ALT is 20-60 IU/L.
Related Pictures
★リンクテーブル★
| リンク元 | 「アラニンアミノトランスフェラーゼ」 |
| 関連記事 | 「L」「alanine」「aminotransferase」 |
「アラニンアミノトランスフェラーゼ」
- 英
- alanine aminotransferase, L-alanine aminotransferase, ALT
- 同
- グルタミン酸ピルビン酸トランスアミナーゼ glutamic-pyruvic transaminase, GPT
- グルタミン酸アラニントランスアミナーゼ glutamic-alanine transaminase、L-アラニン:2-オキソグルタル酸アミノトランスフェラーゼ L-alanine:2-oxoglutarateaminotransferase
- 関
- アスパラギン酸アミノ基転移酵素 AST、マクロALT。アミノ転移
- 臨床検査医学 090113
概念
- 肝細胞からの逸脱酵素。肝以外での含有量は少ない。
- 旧来のGPTおなじ
- 肝細胞障害の指標 → 炎症が沈静化していれば(慢性肝炎や肝硬変の末期)、正常範囲を示しうる。
酵素
- EC 2.6.1.2。
- 分子量：54,637Da
機能
- 可逆的アミノ基転移反応を触媒する
- L-アラニン（L-alanine）＋2-オキソグルタル酸（2-oxoglutarate）＝ピルビン酸（pyruvate）＋L-グルタミン酸（L-glutamate
- 補酵素：ピリドキサールリン酸（VB6）補酵素
- 組織の炎症や挫滅により血中に逸脱
- 消化管から由来する大量のアラニンを肝臓でピルビン酸へと変換し，糖新生の基質として供給
- 全身に存在するが、特に肝臓に多い。
臨床検査
- 基準値：4-43U/L。7-41 U/L(HIM A-3)
- 1,000U/L以上
- 急性ウイルス肝炎
判別
- 高度上昇 ：急性肝炎、劇症肝炎、ショック
- 中程度上昇：急性肝炎ｍ慢性活動性肝炎、閉塞性黄疸
- 軽度上昇 ：脂肪肝、肝硬変、アルコール性肝障害、胆石発作、肝癌、心筋梗塞(うっ血肝により肝細胞障害を来し、軽度上昇)
- ALTは慢性期な疾患でASTより優位となる。(アルコール性の肝疾患や肝硬変、肝癌は異なる)
- 急性ウイルス性肝炎(極期)、慢性肝炎、過栄養性脂肪肝
| AST | ALT | |
| 含有量 | 3 | 1 |
| 局在 | 心筋、肝臓、 骨格筋、腎臓 赤血球 |
肝臓、腎臓、 心臓、骨格筋 |
| 逸脱しやすさ | 逸脱しにくい | 逸脱しやすい |
| 血中半減期 | 2日 | 6日 |
| 肝小葉内の分泌 | 中心静脈 | 辺縁 |
「L」
「alanine」