Kulchitsky細胞
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/13 18:37:13」(JST)
[Wiki en表示]
Not to be confused with Enterochromaffin-like cell.
| Enterochromaffin cell |
|
Serotonin
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| Details |
| Identifiers |
| Latin |
endocrinocytus EC |
| MeSH |
Enterochromaffin+Cells |
| Code |
TH H3.04.02.0.00029 |
| Anatomical terminology
[edit on Wikidata]
|
Enterochromaffin (EC) cells, or "Kulchitsky cells", are a type of enteroendocrine and neuroendocrine cell[1] occurring in the epithelia lining the lumen of the digestive tract and the respiratory tract that release serotonin.
Contents
- 1 Distribution
- 2 Function
- 3 Origin
- 4 Etymology
- 5 "Enterochromaffin-like cells"
- 6 Pathophysiology
- 7 See also
- 8 References
Distribution
In the human gastrointestinal (GI) tract, the EC cells are distributed widely in the epithelium of the stomach,[2] small bowel and colon.
Function
They use the rate-limiting enzyme tryptophan hydroxylase-1 (TPH-1) to synthesize serotonin and contain about 90% of the body's stores of serotonin (5-HT).[3]
In the gastrointestinal tract, 5-HT is important in response to chemical, mechanical[4] or pathological stimuli in the lumen. It activates both secretory and peristaltic reflexes, and activates vagal afferents (via 5-HT3 receptors) that signal to the brain (important in the generation of nausea). Ondansetron is an antagonist of the 5-HT3 receptor and is an effective anti-emetic.
Origin
The enterochromaffin cells are derived from the same stem cells as the rest of the epithelium, and are not derived from the migratory neural crest source that provides the enteric nervous system.[5]
Etymology
They are called "entero"[6] meaning related to the gut and "chromaffin" because of a chromium salt reaction that they share with chromaffin cells of the adrenal medulla (adrenal glands).[7]
"Enterochromaffin-like cells"
Another population of chromaffin cells is found only in the stomach wall, called enterochromaffin-like cells (ECL). They look like EC cells but do not contain 5-HT.
ECL cells respond to gastrin released by G-cells and they release histamine, which will stimulate the parietal cells to produce gastric acid.
Pathophysiology
The neuroendocrine progenitors to enterochromaffin cells in the bronchial epithelium have been implicated in the origin of small cell lung cancer.[8]
See also
- Carcinoid syndrome
- Serotonin
References
- ^ Enterochromaffin Cells at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Simonsson, M. et al. (1988) Endocrine Cells in the Human Oxyntic Mucosa: A Histochemical Study. Scand J Gastro. 23(9):1089-99.
- ^ Josef Donnerer; Fred Lembeck (2006). The chemical languages of the nervous system: history of scientists and substances. Karger Publishers. pp. 161–. ISBN 978-3-8055-8004-5. Retrieved 23 May 2011.
- ^ Bulbring, E., Crema, A., The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J Physiol 1959;146(1):18-28.
- ^ Thompson M, Fleming KA, Evans DJ, Fundele R, Surani MA, Wright NA (October 1990). "Gastric endocrine cells share a clonal origin with other gut cell lineages". Development. 110 (2): 477–81. PMID 2133551.
- ^ Entero- definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
- ^ 1516961798 at GPnotebook
- ^ eMedicine - Lung Cancer, Small Cell : Article by Abid Irshad
|
Physiology of the gastrointestinal system
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| GI tract |
| Upper |
| Exocrine |
- Chief cells
- Parietal cells
- Gastric acid
- Intrinsic factor
- Foveolar cells
- Goblet cells
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| Processes |
|
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| Fluids |
|
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| Lower |
| Enteric nervous system |
- Submucous plexus
- Myenteric plexus
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| Endocrine/paracrine |
- G cells
- D cells
- ECL cells
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|
| enterogastrone: |
|
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- Enteroendocrine cells
- Enterochromaffin cell
- APUD cell
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|
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| Fluids |
|
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| Processes |
- Segmentation contractions
- Migrating motor complex
- Borborygmus
- Defecation
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|
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| Either/both |
| Processes |
- Peristalsis (Interstitial cell of Cajal
- Basal electrical rhythm)
- Gastrocolic reflex
- Digestion
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|
|
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| Accessory |
| Fluids |
|
|
| Processes |
- Enterohepatic circulation
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|
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| Abdominopelvic |
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Cells in humans derived from endoderm
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| Foregut |
| Respiratory |
- Pneumocyte
- Club cell
- Goblet cell
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| Digestive |
| Stomach |
- Enteroendocrine cell
- G cell
- Delta cell
- Enterochromaffin-like cell
- Gastric chief cell
- Parietal cell
- Foveolar cell
|
|
| Intestine |
- Enteroendocrine cell
- Gastric inhibitory polypeptide
- S cell
- Delta cell
- Cholecystokinin
- Goblet cell
- Paneth cell
- Tuft cell
- Enterocyte
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| Liver |
- Hepatocyte
- Hepatic stellate cell
- (Kupffer cell from mesoderm)
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| Gallbladder |
|
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| Exocrine pancreas |
- Centroacinar cell
- Pancreatic stellate cell
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|
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| Islets of Langerhans |
- alpha cell
- beta cell
- delta cell
- F cell(PP cell
- epsilon cell
|
|
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| Pharyngeal pouch |
- Thyroid gland
- Parathyroid gland
- Parathyroid chief cell
- Oxyphil cell
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| Hindgut/cloaca |
|
UpToDate Contents
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English Journal
- Small cell lung cancer with paraneoplastic lipase production.
- Dasanu CA, Clark BA 3rd, Lahiri B, Ichim TE, Alexandrescu DT.SourceDepartment of Hematology-Oncology, Saint Francis Hospital and Medical Center, Hartford, CT, USA. c_dasanu@yahoo.com
- Southern medical journal.South Med J.2010 Aug;103(8):819-22.
- Kulchitsky cells represent the cells of origin of small cell lung cancer (SCLC). They display an antigenic makeup characteristic of both the neural crest and epithelium and have been shown to secrete both polypeptide hormones and enzymes. The coexistence of two or more (concomitant or sequential) pa
- PMID 20622741
- Common Diagnostic Challenges in the Histopathologic Diagnosis of Neuroendocrine Lung Tumors: A Case Report.
- Valente M, Catena L, Milione M, Pusceddu S, Formisano B, Bajetta E.SourceMedical Oncology Unit 2, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy.
- Case reports in oncology.Case Rep Oncol.2010 Jul 2;3(2):202-207.
- Bronchopulmonary neuroendocrine tumors are an uncommon group of neoplasms, accounting for about 20% of all lung carcinomas, arising from stem cells of the bronchial epithelium known as Kulchitsky cells. In the past, these tumors were grouped among benign or less aggressive malignant pulmonary tumors
- PMID 20740197
Japanese Journal
- ラット甲状腺および肺におけるcalcitonin/α-calcitonin gene related peptide遺伝子発現
- 和田 知益,橋本 周郎,小野 雅夫
- 北里医学 17(6), 497-508, 1987-12-31
- … 我々は,前報で,ヒト・ラット肺内分泌細胞,Kulchitsky(K)細胞に,カルテトニン遺伝子関連ペプチド(CGRP)およびそのmRNAが存在することを報告した(北里医学,17巻,389?395,1987)。 …
- NAID 110004704515
Related Links
- en·ter·o·chro·maf·fin cell (ĕn′tə-rō-krō′mə-fĭn) n. See enteroendocrine cell. enterochromaffin cell. See argentaffin cell. enterochromaffin cell ... 9) Contrary to the early theory of derivation from Kulchitsky cells, it is now believed that SCC ...
- Kulchitsky cells definition from the mondofacto online medical dictionary help contact sitemap Kulchitsky cells definition home dictionary word tools courses study skills forum about us Search dictionary help Kulchitsky cells --> ...
★リンクテーブル★
[★]
- 英
- Kulchitsky cell, Kulchitsky cells
- 発生は原腸に由来するとされる
- 肺や消化管に分布している。
- 神経内分泌細胞とされる。
- 腫瘍性の増殖を示す疾患は消化管カルチノイドと呼ばれる。
参考
- http://shutoku.fc2web.com/digital_textbook/internal6/disease_of_intestine.html
[★]
細胞