関: 遺伝性腫瘍、家族性腫瘍

WordNet

pay unsolicited and usually unwanted sexual attention to; "He tries to hit on women in bars"
the act of contacting one thing with another; "repeated hitting raised a large bruise"; "after three misses she finally got a hit" (同)hitting, striking
a conspicuous success; "that song was his first hit and marked the beginning of his career"; "that new Broadway show is a real smasher"; "the party went with a bang" (同)smash, smasher, strike, bang
(baseball) a successful stroke in an athletic contest (especially in baseball); "he came all the way around on Williams hit"
a connection made via the internet to another website; "WordNet gets many hits from users worldwide"
a dose of a narcotic drug
a murder carried out by an underworld syndicate; "it has all the earmarks of a Mafia hit"
affect or afflict suddenly, usually adversely; "We were hit by really bad weather"; "He was stricken with cancer when he was still a teenager"; "The earthquake struck at midnight" (同)strike
drive something violently into a location; "he hit his fist on the table"; "she struck her head on the low ceiling" (同)strike
cause to experience suddenly; "Panic struck me"; "An interesting idea hit her"; "A thought came to me"; "The thought struck terror in our minds"; "They were struck with fear" (同)strike, come_to
hit against; come into sudden contact with; "The car hit a tree"; "He struck the table with his elbow" (同)strike, impinge on, run_into, collide with
cause to move by striking; "hit a ball"
consume to excess; "hit the bottle"
deal a blow to, either with the hand or with an instrument; "He hit her hard in the face"
hit the intended target or goal
a belief that can guide behavior; "the architect has a theory that more is less"; "they killed him on the theory that dead men tell no tales"
a well-substantiated explanation of some aspect of the natural world; an organized system of accepted knowledge that applies in a variety of circumstances to explain a specific set of phenomena; "theories can incorporate facts and laws and tested hypothes
being one more than one; "he received two messages" (同)2, ii
the cardinal number that is the sum of one and one or a numeral representing this number (同)2, II, deuce

PrepTutorEJDIC

〈人・物〉‘を'『打つ』,なぐる / …‘に'『ぶつかる』,衝突する / (…に)〈自分の体〉‘を'『ぶつける』《+『名』+『against』(『on』,『upon』)』+『名』》 / 《話》…‘に'達する / …‘に'ひどい打撃(結果)を与える / 《米》〈事が〉〈人〉‘に'ふと思い浮かぶ;〈人が〉…‘を'ふと見つける / (野球で)〈安打〉‘を'打つ;(クリケットで)〈…点〉‘を'取る / (武器などで)(…を)『打つ』,攻撃する《+『at』+『名』》 / (…に)『ぶつかる』,衝突する《+『against(on, upon)』+『名』》 / 襲う,急に現れる / 『打撃』,命中 / ヒット,大当たり,大成功 / (野球で)ヒット,安打(base hit) / 風刺,当てこすり
〈C〉(…の)(学問的な)『理論』,学説《+of+名》 / 〈C〉〈U〉(…の実地に対する)『理論』《+of+名》 / 〈C〉(…という)『推測』,憶測;見解,孝え《+that節》
〈C〉(数の)『2』,2の記号 / 〈U〉2時,2分;2歳 / 《複数扱い》二人;2個 / 〈C〉二つ(二人,2個)1組のもの / 〈C〉(カードゲーム)2の札,(さいころの)2の目 / 2の;二人の;二つの,2個の / 《補語にのみ用いて》2歳の(で)
《話》(あいさつとして)『やあ』,こんにちは / 《英》(注意を促す発声として)おい,ちょっと(hey)

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1. ヘパリン起因性血小板減少症のマネージメント management of heparin induced thrombocytopenia
2. ヘパリン起因性血小板減少症の臨床症状および診断 clinical presentation and diagnosis of heparin induced thrombocytopenia
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English Journal

Heritable one-hit events defining cancer prevention?

Kopelovich L1, Shea-Herbert B.
Cell cycle (Georgetown, Tex.).Cell Cycle.2013 Aug 15;12(16):2553-7. doi: 10.4161/cc.25690. Epub 2013 Jul 29.
Over 100 years ago (1902-1914) Theodor Boveri suggested a role for mutations in cancer. Boveri's ideas were derived from the then "just-emerging" chromosome theory of inheritance. While demonstrating chromosomal aberrations as a cause of genetic imbalance, Boveri suggested that possible causes of ma
PMID 23907126

The role of noise and positive feedback in the onset of autosomal dominant diseases.

Bosl WJ1, Li R.
BMC systems biology.BMC Syst Biol.2010 Jun 29;4:93. doi: 10.1186/1752-0509-4-93.
BACKGROUND: Autosomal dominant (AD) diseases result when a single mutant or non-functioning gene is present on an autosomal chromosome. These diseases often do not emerge at birth. There are presently two prevailing theories explaining the expression of AD diseases. One explanation originates from t
PMID 20587063

The retinoblastoma paradigm revisited.

Mastrangelo D1, De Francesco S, Di Leonardo A, Lentini L, Hadjistilianou T.
Medical science monitor : international medical journal of experimental and clinical research.Med Sci Monit.2008 Dec;14(12):RA231-40.
BACKGROUND: Retinoblastoma (Rb) is the most common primary malignant intraocular tumour in childhood. The "two hit" theory, formulated by Knudson in 1971 to explain the variegated clinical expression of the disease, led to the discovery of the so called tumour suppressor genes and the identification
PMID 19043380

Japanese Journal

Twists in views on RB functions in cellular signaling, metabolism and stem cells

Takahashi Chiaki,Sasaki Nobunari,Kitajima Shunsuke
Cancer Science 103(7), 1182-1188, 2012-07
… One-quarter of a century ago, identification of the human retinoblastoma gene (RB) loci proved Knudson's 'two-hit theory' that tumor suppressor genes exist. …
NAID 120004161539

６．結節性硬化症遺伝子（Ｔｓｃ２）欠損腎腫よう細胞におけるＳ６キナーゼ活性とＥｒｃ発現制御

小林敏之,百瀬修二,足立浩幸,三谷弘明,小林悦子,平山榕子,樋野興夫
日本疾患モデル学会記録 19, 38-42, 2003
… Two causative genes for TSC. … Both genes act as tumor suppressors, and Knudson's two hit theory can be applied for the development of lesions in TSC. …
NAID 130000760669

小児がん臨床遺伝学とがん家系症候群

恒松由記子
日本小児血液学会雑誌 9(6), 395-403, 1995
… みとめられる染色体の欠失や転座の存在は腫瘍レベルでも解析され各腫瘍の遺伝子座発見の糸口となった.優性遺伝する遺伝性の網膜芽細胞腫の臨床的観察からKnudsonは発がん2段階説いわゆるtwo hit theoryを提唱し, これはがん抑制遺伝子の発見に導いた.CaveneeはRFLPマーカーを用いて網膜芽細胞腫の腫瘍細胞レベルでのヘテロ接合性の消失を示しがん抑制遺伝子の …
NAID 130004346339