WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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1. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
2. 幼児の食物蛋白誘発性直腸炎/大腸炎および腸疾患 food protein induced proctitis colitis and enteropathy of infancy
3. プロテインC欠乏症：臨床症状および診断 protein c deficiency clinical manifestations and diagnosis
4. 第V因子ライデンおよび活性化プロテインC抵抗性：臨床症状および診断 factor v leiden and activated protein c resistance clinical manifestations and diagnosis
5. 肥大型心筋症の遺伝学 genetics of hypertrophic cardiomyopathy

Kcnip1 a Ca²⁺-dependent transcriptional repressor regulates the size of the neural plate in Xenopus.

Néant I1, Mellström B2, Gonzalez P2, Naranjo JR3, Moreau M4, Leclerc C5.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1853(9):2077-85. doi: 10.1016/j.bbamcr.2014.12.007. Epub 2014 Dec 10.
In amphibian embryos, our previous work has demonstrated that calcium transients occurring in the dorsal ectoderm at the onset of gastrulation are necessary and sufficient to engage the ectodermal cells into a neural fate by inducing neural specific genes. Some of these genes are direct targets of c
PMID 25499267

Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.

Cheng CF1, Wang WC1, Huang CY1, Du PH1, Yang JH1, Tsaur ML1.
The Journal of comparative neurology.J Comp Neurol.2015 Aug 3. doi: 10.1002/cne.23876. [Epub ahead of print]
Subthreshold A-type K+ currents (ISA s) have been recorded from the somata of nociceptors and spinal lamina II excitatory interneurons, which sense and modulate pain, respectively. Kv4 channels are responsible for the somatodendritic ISA s. Accumulative evidence suggests that neuronal Kv4 channels a
PMID 26239200

Immunohistochemical localization of DPP10 in rat brain supports the existence of a Kv4/KChIP/DPPL ternary complex in neurons.

Wang WC1, Cheng CF, Tsaur ML.
The Journal of comparative neurology.J Comp Neurol.2015 Mar 1;523(4):608-28. doi: 10.1002/cne.23698. Epub 2014 Dec 19.
Subthreshold A-type K(+) currents (ISA s) have been recorded from the cell bodies of hippocampal and neocortical interneurons as well as neocortical pyramidal neurons. Kv4 channels are responsible for the somatodendritic ISA s. It has been proposed that neuronal Kv4 channels are ternary complexes in
PMID 25355692

Cardiomyocyte-Derived Mitochondrial Superoxide Causes Myocardial Electrical Remodeling by Downregulating Potassium Channels and Related Molecules

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Circulation Journal 78(8), 1950-1959, 2014
… Levels of oxidative stress, potassium channel-related molecules, and K+channel-interacting protein-2 (KChIP2) were also evaluated. … Real-time RT-PCR and Western blotting revealed that Kv4.2 expression was downregulated in both BSO-treated groups, whereas KChIP2 expression was downregulated only in the H/M-Sod2+/–+BSO group (P<0.05).Conclusions:BSO treatment caused hyperoxidative stress in the myocardium of H/M-Sod2+/–mice. …
NAID 130004427935

Intercalated Disc-Associated Protein mXinα Influences Surface Expresession of Ito and IK1 Currents in Ventricular Myocytes

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Journal of Arrhythmia 27(Supplement), SS1_4, 2011
… Mouse Xinα (mXinα) encodes a Xin repeat-containing, actin-binding protein localized to the intercalated disc (ICD). … Juvenile mXinα-null ventricles had reduced levels of membrane-associated KChIP2, an auxiliary subunit of I<SUB>to</SUB>, and filamin, an actin cross-linking protein. …
NAID 130002130107

Tumor Necrosis Factor-α Downregulates the Voltage Gated Outward K^+ Current in Cultured Neonatal Rat Cardiomyocytes : A Possible Cause of Electrical Remodeling in Diseased Hearts(EXPERIMENTAL INVESTIGATION)

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Circulation journal : official journal of the Japanese Circulation Society 70(5), 605-609, 2006-04-20
… Background Inflammatory cytokines have been reported to contribute to the progression of cardiac remodeling in various heart diseases and a remarkable prolongation of the monophasic action potential duration and reductions in the expression of Kv4.2 and K^+ channel-interacting protein-2 (KChIP-2) in a rat autoimmune myocarditis model have been documented. … Among the cardiac ion channel related molecules evaluated in this study, Kv4.2 and KChIP-2 mRNA exhibited remarkable reductions (p<0.05). …
NAID 110004720682