Jarisch-Herxheimer reaction

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/18 20:29:41」(JST)

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  • Elevated CSF Cytokines in the Jarisch-Herxheimer Reaction of General Paresis.
  • Davis LE, Oyer R, Beckham JD, Tyler KL.SourceDepartment of Neurology Service, New Mexico VA Health Care System, Albuquerque.
  • JAMA neurology.JAMA Neurol.2013 Aug 1;70(8):1060-4. doi: 10.1001/jamaneurol.2013.2120.
  • IMPORTANCE The Jarisch-Herxheimer reaction (JHR) is a well-recognized transient worsening of signs and symptoms occurring soon after the first dose of an appropriate antibiotic for several spirochetal infections. The pathogenesis of this reaction is poorly understood. In this case study of cerebrosp
  • PMID 23732875
  • The Jarisch-Herxheimer reaction: Revisited.
  • Belum GR, Belum VR, Chaitanya Arudra SK, Reddy BS.SourceSkin & VD Clinic, Hyderabad, AP, India. Electronic address: drgeetanjali@gmail.com.
  • Travel medicine and infectious disease.Travel Med Infect Dis.2013 Jul-Aug;11(4):231-7. doi: 10.1016/j.tmaid.2013.04.001. Epub 2013 Apr 28.
  • The Jarisch-Herxheimer reaction (JHR) is a transient immunological phenomenon seen commonly in patients during treatment for syphilis, and it manifests clinically with short-term constitutional symptoms such as fever, chills, headache and myalgias, besides exacerbation of existing cutaneous lesions.
  • PMID 23632012


  • Neurosyphilis Mimicking Ramsay Hunt Syndrome
  • Neurosyphilis Is a Long-forgotten Disease but Still a Possible Etiology for Dementia
  • 症例 抗生剤治療によって精神症状が可逆的であった神経梅毒の1例


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関連記事reaction」「Herxheimer reaction



Jarisch-Herxheimer reaction
ヘルクスハイマー反応 Herxheimer reactionヤーリッシュ-ヘルクスハイマー反応 Jarisch-Herxheimer反応Jarisch-Herxheimer現象ヤーリッシ・ヘルクスハイマー反応
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  • 抗生剤投与により生じる発熱(38℃以上)、頭痛、悪寒、血圧低下、呼吸促迫などの全身症状
  • 病原菌が急激に死滅したための反応
  • 梅毒回帰熱の治療で見られる


  • 第二期で多い(文献によっては第一期と第二期に多いという記載有り)
  • ペニシリン治療を開始して2-4時間後に現れる




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「a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age"」

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「doing something in opposition to another way of doing it that you don''t like; "his style of painting was a reaction against cubism"」

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「(mechanics) the equal and opposite force that is produced when any force is applied to a body; "every action has an equal and opposite reaction"」

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「a response that reveals a person''s feelings or attitude; "he was pleased by the audience''s reaction to his performance"; "John feared his mother''s reaction when she saw the broken lamp"」

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「an idea evoked by some experience; "his reaction to the news was to start planning what to do"」

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「extreme conservatism in political or social matters; "the forces of reaction carried the election"」

PrepTutorEJDIC   license prepejdic

「{名}(…に対する)『反応』《+『to』+『名』》 / 〈U〉(…に対する)(政治的・社会的な)『反動』,逆コース《+『against』+『名』》 / 〈U〉〈C〉化学反応,化学変化 / 〈U〉〈C〉(物理学で)反作用」

Herxheimer reaction」

  [★] ヘルクスハイマー反応