Janus kinase

出典: meddic


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/02 21:31:34」(JST)

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  • A novel role for thrombopoietin in regulating osteoclast development in humans and mice.
  • Bethel M1, Barnes CL2, Taylor AF1, Cheng YH1, Chitteti BR3, Horowitz MC2, Bruzzaniti A4,5, Srour EF3,6,7, Kacena MA1,2,5.
  • Journal of cellular physiology.J Cell Physiol.2015 Sep;230(9):2142-51. doi: 10.1002/jcp.24943.
  • Emerging data suggest that megakaryocytes (MKs) play a significant role in skeletal homeostasis. Indeed, osteosclerosis observed in several MK-related disorders may be a result of increased numbers of MKs. In support of this idea, we have previously demonstrated that MKs increase osteoblast (OB) pro
  • PMID 25656774
  • Stimulation of cardiomyogenesis from mouse embryonic stem cells by nuclear translocation of cardiotrophin-1.
  • Mascheck L1, Sharifpanah F1, Tsang SY2, Wartenberg M3, Sauer H4.
  • International journal of cardiology.Int J Cardiol.2015 Aug 15;193:23-33. doi: 10.1016/j.ijcard.2015.05.019. Epub 2015 May 8.
  • BACKGROUND: Cardiotrophin-1 (CT-1) controls cardiomyogenesis of mouse embryonic stem (ES) cells.OBJECTIVES: To investigate the signaling pathway underlying the action of CT-1 on cardiac cell differentiation.METHODS: Protein expression was analyzed by western blot technique and cardiac areas by immun
  • PMID 26005169
  • Remission of systemic lupus erythematosus disease activity with regulatory cytokine interleukin (IL)-35 in Murphy Roths Large (MRL)/lpr mice.
  • Cai Z1,2, Wong CK1,2,3, Dong J1,2, Chu M1,2, Jiao D1,2, Kam NW2,4, Lam CW5, Tam LS2,4.
  • Clinical and experimental immunology.Clin Exp Immunol.2015 Aug;181(2):253-66. doi: 10.1111/cei.12639.
  • The immunological mechanisms mediated by regulatory cytokine interleukin (IL)-35 are unclear in systemic lupus erythematosus (SLE). We investigated the frequency of CD4(+) CD25(+) forkhead box protein 3 (FoxP3)(+) regulatory T (Treg ) and IL-10(+) regulatory B (Breg ) cells and related immunoregulat
  • PMID 25845911


  • 新規低分子標的薬を使いこなす (特集 プライマリケア医もできる! 関節リウマチ診療) -- (関節リウマチ治療各論 : エビデンスも踏まえて)
  • 分子標的薬である低分子化合物JAK阻害薬 (特集 今,知っておきたい「リウマチ」のすべて) -- (薬物治療の新しい話題)
  • 関節リウマチにおける抗リウマチ薬と帯状疱疹


Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors ...
The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Birds, fish and insects also ...