JNK

出典: meddic

c-Jun N-terminal kinase, c-Jun NH2-terminal kinase, JNK mitogen-activated protein kinase
SAPK
MAPキナーゼスーパーファミリーカスケード
  • MAPKファミリーの一つ。JNK1/2/3がある。
  • JNK1:全身組織に発現
  • JNK2:全身組織に発現
  • JNK3:脳に限局

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/25 05:26:55」(JST)

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英文文献

  • Gene expression profiling and pathway analysis identify the integrin signaling pathway to be altered by IL-1β in human pancreatic cancer cells: Role of JNK.
  • Verma G, Bhatia H, Datta M.SourceCSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110 007, India.
  • Cancer letters.Cancer Lett.2012 Jul 1;320(1):86-95. Epub 2012 Feb 4.
  • The pro-inflammatory cytokine, IL-1β, is a critical component of the persistent inflammatory milieu that pancreatic cancer cells frequently encounter. Although several studies report diverse mechanisms responsible for this association, yet a comprehensive global analysis of the effect of IL-1β in
  • PMID 22313544
  • Stress-activated protein kinases are involved in porcine reproductive and respiratory syndrome virus infection and modulate virus-induced cytokine production.
  • Lee YJ, Lee C.AbstractThe present study examined the role of the p38 MAPK and JNK pathways during PRRSV infection in immortalized porcine alveolar macrophage (PAM) cells. Infection with PRRSV was found to progressively activate p38 and JNK1/2 up to 36h postinfection and then their phosphorylation levels dramatically decreased to baseline at 48h postinfection. In contrast, UV-inactivated PRRSV failed to trigger phosphorylation of these SAPKs, indicating that the post-entry process is responsible for their activation. Independent treatment of cells with a selective p38 or JNK inhibitor markedly impaired PRRSV infection, resulting in significant reduction in synthesis of viral genomic and subgenomic RNAs, viral protein expression, and progeny virus production. Notably, cytokine production in PAM cells infected with PRRSV was shown to be altered by inhibiting these SAPKs. Altogether, our data suggest that the p38 and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
  • Virology.Virology.2012 Jun 5;427(2):80-9. Epub 2012 Mar 16.
  • The present study examined the role of the p38 MAPK and JNK pathways during PRRSV infection in immortalized porcine alveolar macrophage (PAM) cells. Infection with PRRSV was found to progressively activate p38 and JNK1/2 up to 36h postinfection and then their phosphorylation levels dramatically decr
  • PMID 22424736

和文文献

  • 1-O-Tigloyl-1-O-deacetyl-nimbolinin B Inhibits LPS-Stimulated Inflammatory Responses by Suppressing NF-κB and JNK Activation in Microglia Cells
  • Tao Li,Zhang Fali,Hao Lili [他]
  • Journal of pharmacological sciences 125(4), 364-374, 2014-08
  • NAID 40020164468
  • Kobophenol A Inhibits Sodium Nitroprusside-Induced Cardiac H9c2 Cell Death through Suppressing Activation of JNK and Preserving Mitochondrial Anti-apoptotic Bcl-2 and Mcl-1
  • Lee Sung Ryul,Kwak Jong Hwan,Noh Su Jin [他]
  • Chemical and pharmaceutical bulletin 62(7), 713-718, 2014-07
  • NAID 40020103681
  • 16α,17α-Epoxypregnenolone-20-oxime Prevent LPS-Induced NO Production and iNOS Expression in BV-2 Microglial Cells by Inhibiting JNK Phosphorylation
  • Sun Hu-Nan,Jin Mei-Hua,Han Bing [他]
  • Biological & pharmaceutical bulletin 37(7), 1096-1102, 2014-07
  • NAID 40020103442

関連リンク

米国CST社の日本法人CSTジャパン株式会社【公式サイト】SAPK/JNK シグナルカスケード (SAPK/JNK Signaling Cascade)ページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
バークレイズ・ハイ・イールド・ベリー・リキッド指数の価格と利回りに、経費控除前で、おおむね連動する投資成果 ... ティッカーシンボル JNK US プライマリー ベンチマーク バークレイズ・ハイ・ イールド・ベリー・リキッド 指数 CUSIP

関連画像

2003 Nature Publishing Group of the JNK signal transduction cascadejnk pathway 6 10 from 5 votes jnk pathway Copyright © 2001-2014 Daniele Focosi .All The JNK signaling pathway is a conserved  control of JNK and p38 MAPK pathways


★リンクテーブル★
リンク元c-Jun N-terminal kinase
拡張検索JNK mitogen-activated protein kinase」「JNK kinase」「MAPキナーゼJNK
関連記事J」「JN

c-Jun N-terminal kinase」

  [★]

c-Jun N末端キナーゼ

c-Jun NH2-terminal kinase、JNKJNK mitogen-activated protein kinase

JNK mitogen-activated protein kinase」

  [★]

MAPキナーゼJNK、c-Jun N末端キナーゼ

c-Jun N-terminal kinase、c-Jun NH2-terminal kinase、JNK

JNK kinase」

  [★]

JNKキナーゼ

MAP kinase kinase 4mitogen-activated protein kinase kinase 4

MAPキナーゼJNK」

  [★]

JNK mitogen-activated protein kinase
c-Jun N末端キナーゼ


J」

  [★]

joule

WordNet   license wordnet

「the 10th letter of the Roman alphabet」
j

PrepTutorEJDIC   license prepejdic

「(連続するものの)10番目,第10番のもの」


JN」

  [★]

juvenile nephronophthisis


"http://meddic.jp/JNK" より作成


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