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Achromobacter denitrificans SP1 produces pharmaceutically active 25C prodigiosin upon utilizing hazardous di(2-ethylhexyl)phthalate.

Pradeep S1, Sarath Josh MK1, Balachandran S2, Sudha Devi R2, Sadasivam R3, Thirugnanam PE4, Doble M5, Anderson RC6, Benjamin S7.
Bioresource technology.Bioresour Technol.2014 Nov;171:482-6. doi: 10.1016/j.biortech.2014.08.077. Epub 2014 Aug 23.
This first report describes the purification and identification of an orange-red pigment produced by Achromobacter denitrificans strain SP1 (isolated from sewage sludge heavily contaminated with plastics) during its growth in a simple basal salt medium supplemented with the hazardous di(2-ethylhexyl
PMID 25201292

Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells.

Kim SM1, Lee JH1, Sethi G2, Kim C1, Baek SH1, Nam D1, Chung WS1, Kim SH1, Shim BS1, Ahn KS3.
Cancer letters.Cancer Lett.2014 Nov 1;354(1):153-63. doi: 10.1016/j.canlet.2014.08.002. Epub 2014 Aug 14.
Persistent activation of signal transducers and activator of transcription 3 (STAT3) has been closely related to growth, survival, proliferation, metastasis, and angiogenesis of various cancer cells, and thus its inhibition can be considered a potential therapeutic strategy. In this study, we invest
PMID 25130169

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Foka P1, Dimitriadis A, Kyratzopoulou E, Giannimaras DA, Sarno S, Simos G, Georgopoulou U, Mamalaki A.
Cellular and molecular life sciences : CMLS.Cell Mol Life Sci.2014 Nov;71(21):4243-58. doi: 10.1007/s00018-014-1621-4. Epub 2014 Apr 10.
Hepatitis C virus (HCV) infection is associated with hepatic iron overload and elevated serum iron that correlate to poor antiviral responses. Hepcidin (HAMP), a 25-aa cysteine-rich liver-specific peptide, controls iron homeostasis. Its expression is up-regulated in inflammation and iron excess. HCV
PMID 24718935