イソプリノシン
- 関
- inosine pranobex
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/29 13:56:12」(JST)
[Wiki en表示]
Inosine pranobex
INN: Inosine acedoben dimepranol
|
Chemical structures of the three components of inosine pranobex
|
| Combination of |
| Inosine |
Immunostimulant |
| Acedoben dimepranol |
Immunostimulant |
| Clinical data |
| Trade names |
Imunovir, Delimmun, Isoprinosine |
| ATC code |
J05AX05 (WHO) |
| Identifiers |
| Synonyms |
Methisoprinol |
| CAS Number |
36703-88-5 |
| PubChem (CID) |
37510 |
| ChemSpider |
16736312 |
| KEGG |
D01995 |
| ECHA InfoCard |
100.048.313 |
Inosine pranobex (BAN; also known as inosine acedoben dimepranol (INN) or methisoprinol) an antiviral drug that is a combination of inosine and dimepranol acedoben (a salt of acetamidobenzoic acid and dimethylaminoisopropanol) in a ratio of 1 to 3. Inosine pranobex has no effect on viral particles itself. Instead, it acts as a immunostimulant, an analog of thymus hormones.[1] It is most commonly used to treat the rare measles complication subacute sclerosing panencephalitis in conjunction with intrathecal interferon therapy.[2]
In the UK, inosine pranobex is also indicated for mucocutaneous infections due to herpes simplex virus (type 1 and type II) and for treatment of genital warts as adjunctive therapy to podophyllin or carbon dioxide laser.[3]
References
- ^ American Cancer Society. "Inosine Pranobex". Retrieved 31 July 2013. [dead link]
- ^ Campoli-Richards DM, Sorkin EM, Heel RC (Nov 1986). "Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy". Drugs. 32 (5): 383–424. doi:10.2165/00003495-198632050-00001.
- ^ "Imunovir 500mg Tablets". UK Electronic Medicines Compendium.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop.
- Smith ME, Haney E, McDonagh M, Pappas M, Daeges M, Wasson N, Fu R, Nelson HD.
- Annals of internal medicine.Ann Intern Med.2015 Jun 16;162(12):841-50. doi: 10.7326/M15-0114.
- BACKGROUND: Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) is a debilitating multisystem condition affecting more than 1 million adults in the United States.PURPOSE: To determine benefits and harms of treatments for adults with ME/CFS and identify future research needs.DATA SOURCES: M
- PMID 26075755
- Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes.
- Lasek W, Janyst M, Wolny R, Zapała Ł, Bocian K, Drela N.
- Acta pharmaceutica (Zagreb, Croatia).Acta Pharm.2015 Jun 1;65(2):171-80. doi: 10.1515/acph-2015-0015.
- Inosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity. In the present study, effects of Inos on the production of cytokines attributable to Th1 (IL-2, IFN-g, and TNF-a
- PMID 26011933
- Multicenter randomized study of inosine pranobex versus acyclovir in the treatment of recurrent herpes labialis and recurrent herpes genitalis in Chinese patients.
- You Y1, Wang L1, Li Y2, Wang Q3, Cao S4, Tu Y5, Li S6, Bai L7, Lu J8, Wei Z9, Chen W10, Hao F1.
- The Journal of dermatology.J Dermatol.2015 Jun;42(6):596-601. doi: 10.1111/1346-8138.12845. Epub 2015 Mar 26.
- The objective of the study is to evaluate the efficacy and safety of oral inosine pranobex as compared with acyclovir in the treatment of recurrent herpes labialis (RHL) and recurrent herpes genitalis (RHG). A multicenter double-blind, double-dummy, randomized, controlled, parallel group trial was c
- PMID 25819042
Japanese Journal
- Alpha-interferon and isoprinosine in adult-onest subacute sclerosing panencephalitis
- Combined oral isoprinosine-intraventricular α-interferon therapy for subacute sclerosing panencephalitis
- Isoprinosine treatment of alopecia areata
★リンクテーブル★
[★]
- 英
- inosine pranobex
- 商
- イソプリノシン Isoprinosine