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the 9th letter of the Roman alphabet (同)i

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iodineの化学記号
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1. 急性骨髄性白血病における細胞遺伝学的異常cytogenetic abnormalities in acute myeloid leukemia [show details]
…cytogenetic abnormalities . Inversion (inv) – Chromosomal inversion (inv) requires two breaks in the same chromosome with rotation of the intervening material. An example is inv(16)(p13.1q22), wherein genes previously …
2. 先天性の細胞遺伝学的異常congenital cytogenetic abnormalities [show details]
…at prenatal testing. The inv dup(15) markers are classified as two subtypes based upon breakpoint on the long (q) arm: a small inv dup(15) with the break at 15q11 and a large inv dup(15) containing the …
3. 急性骨髄性白血病の分子遺伝学molecular genetics of acute myeloid leukemia [show details]
…alternative C-terminal sequences derived from partner genes on 3q26. EVI1 is also involved in the inv(3)(q21q26) and t(3;3)(q21;q26) in AML . However the consequence of these chromosome aberrations is …
4. 急性骨髄性白血病の分類classification of acute myeloid leukemia [show details]
…approximately 5 percent of adults with newly diagnosed AML . One of these abnormalities, AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22), was previously classified as acute myelomonocytic leukemia with …
5. IgGサブクラス：物理学的性質、遺伝的特徴、および生物学的機能igg subclasses physical properties genetics and biologic functions [show details]
… markers or allotypes . Thus, allotyping is used to distinguish an antibody of a particular subclass encoded by allele "a" from an antibody of the same isotype encoded by allele "b." Allotype nomenclature …

English Journal

The forgotten tale of immunoglobulin allotypes in cancer risk and treatment.

Pandey JP, Li Z.AbstractABSTRACT: Monoclonal antibody (mAb) has fulfilled the promise of being the "Magic Bullet" in oncology with the clinical success of mAbs against CD20, Her-2/neu, epidermal growth factor receptor, vascular endothelial cell growth factor and others in a variety of cancers. Most manufacturers of mouse-human chimeric antibodies (and most immunologists) have treated the constant region of human immunoglobulin (Ig) as if it were naturally monomorphic and therefore not immunogenic in humans. In fact, the constant region of Ig heavy and light chain is highly polymorphic, and yet Ig haplotypes are usually not defined by genome-wide association studies nor are they considered to be important for optimizing mAb therapy. We hereby summarize evidence that Ig allotypes are important and biologically relevant in that they contribute to the etiopathogenesis of many malignant, infectious, and autoimmune diseases. Because Ig allotypes differ from each other in engaging Fc receptor, we argue that future development of effective mAb therapy for cancer should take a patient-specific approach by using the correct allotype for each patient to maximize the efficacy of this therapy.
Experimental hematology & oncology.Exp Hematol Oncol.2013 Feb 20;2(1):6. [Epub ahead of print]
ABSTRACT: Monoclonal antibody (mAb) has fulfilled the promise of being the "Magic Bullet" in oncology with the clinical success of mAbs against CD20, Her-2/neu, epidermal growth factor receptor, vascular endothelial cell growth factor and others in a variety of cancers. Most manufacturers of mouse-h
PMID 23425356

Immunoglobulin GM allotypes in multiple sclerosis.

Pandey JP.SourceDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC.
Annals of neurology.Ann Neurol.2013 Jan;73(1):148. doi: 10.1002/ana.23804.
PMID 23378332

Association between Immunoglobulin GM and KM Genotypes and Placental Malaria in HIV-1 Negative and Positive Women in Western Kenya.

Iriemenam NC, Pandey JP, Williamson J, Blackstock AJ, Yesupriya A, Namboodiri AM, Rocca KM, van Eijk AM, Ayisi J, Oteino J, Lal RB, Ter Kuile FO, Steketee R, Nahlen B, Slutsker L, Shi YP.SourceDivision of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
PloS one.PLoS One.2013;8(1):e53948. doi: 10.1371/journal.pone.0053948. Epub 2013 Jan 11.
Immunoglobulin (Ig) GM and KM allotypes, genetic markers of γ and κ chains, are associated with humoral immune responsiveness. Previous studies have shown the relationships between GM6-carrying haplotypes and susceptibility to malaria infection in children and adults; however, the role of the gene
PMID 23326546

Related Links

Inv allotypes

Look at other dictionaries: INV — inferior nasal vein; Inini virus * * * [from the name of the propositus] see Km allotypes, under allotype … Medical dictionary Inv — inversion; involuntary * * * [from the name of the propositus] see Km allotypes, under allotype …

Inv(1) Allotype: Effect of Immunoglobulin G Heavy Chain ...

Inv (1) Allotype: Effect of Immunoglobulin G Heavy Chain Subtype on Its Expression. Steinberg, Arthur G. ; Rostenberg, Israel. Abstract. More protein is required to detect the Inv (1) antigen carried in the light chain of immunoglobulin G molecules when the light chain is combined with a γ 2 heavy chain than when it is combined with a γ 1 or ...

Gm and Inv allotypes of some Sidamo Ethiopians - Steinberg ...

All samples were tested for Inv(1), and those positive for Inv(1) were tested for Inv(3). The samples fall into 18 Gm phenotypes and require seven haplotypes to explain them. The data indicate that these Ethiopians have Negroid, Caucasoid, and Bushmanoid ancestry, with the latter constituting a relatively small proportion of the ancestry and the former two contributing about equally to the ...