関: immunoproliferative small intestinal disease

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1. 重鎖病 the heavy chain diseases
2. 原発性消化管リンパ腫の臨床症状および診断 clinical presentation and diagnosis of primary gastrointestinal lymphomas
3. 消化管リンパ腫のマネージメント management of gastrointestinal lymphomas
4. 節外（MALT）および節性濾胞辺縁帯リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of extranodal malt and nodal marginal zone lymphomas
5. 小腸腫瘍の疫学、臨床的特徴、および種類 epidemiology clinical features and types of small bowel neoplasms

English Journal

MALT lymphoma of the small bowel with protein-losing enteropathy.

Tsukamoto A, Nakamura F, Nannya Y, Kobayashi Y, Shibahara J, Ichikawa M, Fukayama M, Koike K, Kurokawa M.Author information Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.AbstractMucosa-associated lymphoid tissue (MALT) lymphoma usually arises from chronic inflammation. We herein report a case of small intestinal MALT lymphoma with protein-losing enteropathy (PLE). A 73-year-old woman presented with lower leg edema and severe hypoalbuminemia. She had a medical history of pylorus-preserving pancreaticoduodenectomy with Billroth II reconstruction. Oral and anal route double-balloon enteroscopies revealed irregular nodular mucosal lesions with erosion extending from the jejunum to terminal ileum. Histopathological evaluation of the biopsied mucosa showed proliferation of small-to-medium-sized lambda light chain-restricted B cells. Plasmacytic differentiation and lymphoepithelial lesions were present, leading to the diagnosis of MALT lymphoma. Tc-99m albumin scintigraphy indicated tracer exudation in the small bowel, suggesting the presence of PLE. Combination immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) regimen improved both MALT lymphoma and PLE, whereas rituximab monotherapy was not successful. This case is considered to be common type of MALT lymphoma at an uncommon site and is distinct from immunoproliferative small intestinal disease (IPSID). To our knowledge, this is the first case of non-IPSID-type small intestinal MALT lymphoma complicated by PLE. Gastrointestinal reconstruction may be responsible for underlying chronic inflammation via small intestinal bacterial overgrowth.
International journal of hematology.Int J Hematol.2014 Jan 7. [Epub ahead of print]
Mucosa-associated lymphoid tissue (MALT) lymphoma usually arises from chronic inflammation. We herein report a case of small intestinal MALT lymphoma with protein-losing enteropathy (PLE). A 73-year-old woman presented with lower leg edema and severe hypoalbuminemia. She had a medical history of pyl
PMID 24395281

A case of mucosa-associated lymphoid tissue lymphoma of the gastrointestinal tract showing extensive plasma cell differentiation with prominent Russell bodies.

Kai K, Miyahara M, Tokuda Y, Kido S, Masuda M, Takase Y, Tokunaga O.Author information Keita Kai, Masanori Masuda, Yukari Takase, Osamu Tokunaga, Departments of Pathology and Microbiology, Saga University Faculty of Medicine, Saga 849-8501, Japan.AbstractA 73-year-old Japanese woman was hospitalized for detailed examination of nausea, diarrhea and loss of appetite. Atypical erosion in the ileum was found on endoscopy. Biopsy of this erosion showed proliferation of cells containing numerous Russell bodies. Differential diagnoses considered were Russell body enteritis, crystal-storing histiocytosis, Mott cell tumor, immunoproliferative small intestinal disease (IPSID) and mucosa-associated lymphoid tissue (MALT) lymphoma. The cells containing prominent Russell bodies showed diffuse positivity for CD79a and CD138, but negative results for CD20, CD3, UCHL-1, CD38 and CD68. Russell bodies were diffusely positive for lambda light chain, but negative for kappa light chain, and immunoglobulin (Ig) G, IgA and IgM. Based on these findings, Russell body enteritis, crystal-storing histiocytosis and IPSID were ruled out. As the tumor formed no mass lesions and was restricted to the gastrointestinal tract, MALT lymphoma with extensive plasma cell differentiation was finally diagnosed. The patient showed an unexpectedly aggressive clinical course. The number of atypical lymphocytes in peripheral blood gradually increased and T-prolymphocytic leukemia (T-PLL) emerged. The patient died of T-PLL 7 mo after admission. Autopsy was not permitted.
World journal of clinical cases.World J Clin Cases.2013 Aug 16;1(5):176-80. doi: 10.12998/wjcc.v1.i5.176.
A 73-year-old Japanese woman was hospitalized for detailed examination of nausea, diarrhea and loss of appetite. Atypical erosion in the ileum was found on endoscopy. Biopsy of this erosion showed proliferation of cells containing numerous Russell bodies. Differential diagnoses considered were Russe
PMID 24303496

Immunoproliferative small intestinal disease associated with Campylobacter jejuni.

Mesnard B, De Vroey B, Maunoury V, Lecuit M.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.Dig Liver Dis.2012 Sep;44(9):799-800. doi: 10.1016/j.dld.2012.03.020. Epub 2012 Apr 30.
PMID 22552252

Japanese Journal

Immunoproliferative Small Intestinal Disease with Protein Loss Complicated with Duodenal T Cell Lymphoma during Progression

Hara Takeshi,Tsurumi Hisashi,Kato Tomohiro,Imao Yasuyuki,Kojima Yasushi,Kojima Keishi,Kitagawa Jun-ichi,Katsumura Naoki,Araki Hiroshi,Takami Tsuyoshi,Moriwaki Hisataka
Internal Medicine 47(4), 299-303, 2008
… Histopathological and immunological examination resulted in a diagnosis of immunoproliferative small intestinal disease (IPSID). … He was diagnosed with relapsed IPSID and salvage chemotherapy was started. …
NAID 130000079740