イノシトール1,4,5-トリスリン酸受容体、イノシトール三リン酸受容体、IP3受容体、IP3レセプター

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the 9th letter of the Roman alphabet (同)i
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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iodineの化学記号
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/23 07:27:18」(JST)

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Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca²⁺ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory.^[2] Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca²⁺ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca²⁺ signals characterized by complex patterns relative to both space and time. For example, Ca²⁺ waves and oscillations.^[3] The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine. ^[4]

Distribution

It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the InsP3Rs are found in the cell integrated into the endoplasmic reticulum.

Structure

The asymmetric structure consists of an N-terminal beta-trefoil domain and a C-terminal alpha helical domain with a folding pattern similar to an armadillo repeat fold. The split formed by the two terminals contains multiple arginine and lysine residues that coordinate the three phosphoryl groups of InsP3.^[2] The InsP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. InsP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further InsP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.

References

^ Bosanac I, Yamazaki H, Matsu-Ura T, Michikawa T, Mikoshiba K, Ikura M (January 2005). "Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor". Mol. Cell 17 (2): 193–203. doi:10.1016/j.molcel.2004.11.047. PMID 15664189.
^ ^a ^b Bosanac I, Alattia JR, Mal TK, et al. (December 2002). "Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand". Nature 420 (6916): 696–700. doi:10.1038/nature01268. PMID 12442173.
^ Yoshida Y, Imai S (June 1997). "Structure and function of inositol 1,4,5-trisphosphate receptor". Jpn. J. Pharmacol. 74 (2): 125–37. doi:10.1254/jjp.74.125. PMID 9243320.
^ Supattapone S, et al. J Biol Chem. 1988 Jan 25;263(3):1530-4.

External links

Inositol Trisphosphate Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

Analysis of IP(3) receptors in and out of cells.

Rossi AM, Tovey SC, Rahman T, Prole DL, Taylor CW.AbstractBACKGROUND: Inositol 1,4,5-trisphosphate receptors (IP(3)R) are expressed in almost all animal cells. Three mammalian genes encode closely related IP(3)R subunits, which assemble into homo- or hetero-tetramers to form intracellular Ca(2+) channels. SCOPE OF THE REVIEW: In this brief review, we first consider a variety of complementary methods that allow the links between IP(3) binding and channel gating to be defined. How does IP(3) binding to the IP(3)-binding core in each IP(3)R subunit cause opening of a cation-selective pore formed by residues towards the C-terminal? We then describe methods that allow IP(3), Ca(2+) signals and IP(3)R mobility to be examined in intact cells. A final section briefly considers genetic analyses of IP(3)R signalling.
Biochimica et biophysica acta.Biochim Biophys Acta.2012 Aug;1820(8):1214-27. Epub 2011 Oct 14.
BACKGROUND: Inositol 1,4,5-trisphosphate receptors (IP(3)R) are expressed in almost all animal cells. Three mammalian genes encode closely related IP(3)R subunits, which assemble into homo- or hetero-tetramers to form intracellular Ca(2+) channels. SCOPE OF THE REVIEW: In this brief review, we first
PMID 22033379

Homers regulate calcium entry and aggregation in human platelets: a role for Homers in the association between STIM1 and Orai1.

Jardin I, Albarrán L, Bermejo N, Salido GM, Rosado JA.Source*Department of Physiology, Cellular Physiology Research Group, University of Extremadura, 10003 Caceres, Spain.
The Biochemical journal.Biochem J.2012 Jul 1;445(1):29-38.
Homer is a family of cytoplasmic adaptor proteins that play different roles in cell function, including the regulation of G-protein-coupled receptors. These proteins contain an Ena (Enabled)/VASP (vasodilator-stimulated phosphoprotein) homology 1 domain that binds to the PPXXF sequence motif, which
PMID 22506990

Japanese Journal

Characteristics of spontaneous calcium oscillations in renal tubular epithelial cells

UDAGAWA Takashi,HANAOKA Kazushige,KAWAMURA Masahiro,HOSOYA Tatsuo
Clinical and experimental nephrology 16(3), 389-398, 2012-06-01
NAID 10030808392

Interleukin-13 enhanced Ca[2+] oscillations in airway smooth muscle cells.

Matsumoto Hisako,Hirata Yutaka,Otsuka Kojiro,Iwata Toshiyuki,Inazumi Aya,Niimi Akio,Ito Isao,Ogawa Emiko,Muro Shigeo,Sakai Hiroaki,Chin Kazuo,Oku Yoshitaka,Mishima Michiaki
Cytokine 57(1), 19-24, 2012-01
… mRNA expressions of cysteinyl leukotriene 1 receptors (CysLT1R), CD38, involved with the ryanodine receptors (RyR) system, and transient receptor potential canonical (TRPC), involved with store-operated Ca[2+] entry (SOCE), were determined by real-time PCR. …
NAID 120003726117

Function and Regulation of Endothelin Type A Receptor-Operated Transient Receptor Potential Canonical Channels

HORINOUCHI Takahiro,TERADA Koji,HIGA Tsunaki,AOYAGI Hiroyuki,NISHIYA Tadashi,SUZUKI Hiroyuki,MIWA Soichi
Journal of pharmacological sciences 117(4), 295-306, 2011-12-20
… The purpose of this study is to identify transient receptor potential canonical (TRPC) channels responsible for receptor-operated Ca<SUP>2+</SUP> …
NAID 10030453850

Related Pictures

★リンクテーブル★

リンク元	「inositol 1,4,5-trisphosphate receptor」「イノシトール1,4,5-トリスリン酸受容体」「IP3R」
拡張検索	「IP3 receptors」
関連記事	「I」「IP」「IP3」

「inositol 1,4,5-trisphosphate receptor」

inositol 1,4,5-trisphosphate receptor, type 3
Identifiers
Symbol	ITPR3
Entrez	3710
HUGO	6182
OMIM	147267
RefSeq	NM_002224
UniProt	Q14573
Other data
Locus	Chr. 6 p21.31

inositol 1,4,5-trisphosphate receptor, type 2
Identifiers
Symbol	ITPR2
Entrez	3709
HUGO	structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181 Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181
OMIM	600144
RefSeq	NM_002223
UniProt	Q14571
Other data
Locus	Chr. 12 p11.23

inositol 1,4,5-trisphosphate receptor, type 1
	Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor
Identifiers
Symbol	ITPR1
Entrez	3708
HUGO	6180
OMIM	147265
RefSeq	NM_002222
UniProt	Q14643
Other data
Locus	Chr. 3 p26.1