インターロイキン4受容体、インターロイキン4レセプター、IL-4受容体、IL-4レセプター

関: IL4 receptor、interleukin-4 receptor

WordNet

the 9th letter of the Roman alphabet (同)i
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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『私は』私が
iodineの化学記号
=sense organ / 受信装置
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/08/27 18:29:31」(JST)

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The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

Function

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.^[5] Interactions of IL-4 with TNFα promote structural changes to vascular endothelial cells, thus playing an important role in tissue inflammation.^[6]

The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Alternatively activated macrophages (AAMΦ) downregulate inflammatory mediators such as IFNγ during immune responses, particularly with regards to helminth infections.^[7]

Interactions

Interleukin-4 receptor has been shown to interact with SHC1.^[8]^[9]

Structure

The N-terminal (extracellular) portion of interleukin-4 receptor is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077238 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030748 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ "Entrez Gene: IL4R interleukin 4 receptor".
^ Thornhill, MH; Wellicome, SM; Mahiouz, DL; Lanchbury, JSS; Kyanaung, U; Haskard, DO (Jan 1991). "Tumor-necrosis-factor combines with IL-4 or IFN-gamma to selectively enhance endothelial-cell adhesiveness for T-cells-the contribution of vascular cell-adhesion molecule-1-dependent and molecule-1-independent binding mechanisms". Journal of Immunology. 146 (2): 592–598. PMID 1702807.
^ Tundup S, Srivastava L, Harn DA (April 2012). "Polarization of host immune responses by helminth-expressed glycans". Ann. N. Y. Acad. Sci. 1253: E1–E13. doi:10.1111/j.1749-6632.2012.06618.x. PMID 22974465.
^ Ikizawa K, Yanagihara Y (February 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. PMID 10652211.
^ Kashiwada M, Giallourakis CC, Pan PY, Rothman PB (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. 167 (11): 6382–7. doi:10.4049/jimmunol.167.11.6382. PMID 11714803.
^ Hage T, Sebald W, Reinemer P (April 1999). "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface". Cell. 97 (2): 271–81. doi:10.1016/S0092-8674(00)80736-9. PMID 10219247.

External links

CD124+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the public domain Pfam and InterPro IPR015319

UpToDate Contents

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1. 喘息の遺伝学 genetics of asthma
2. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
3. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
4. ステロイド抵抗性喘息 glucocorticoid resistant asthma
5. 喘息治療の代替剤および経験的薬剤 alternative and experimental agents for the treatment of asthma

English Journal

Enteric nematodes and the path to up-regulation of type 2 cytokines IL-4 and IL-13.

Shea-Donohue T1, Sun R2, Bohl JA3, McLean LP3, Zhao A4.
Cytokine.Cytokine.2015 Sep;75(1):62-7. doi: 10.1016/j.cyto.2015.06.007. Epub 2015 Jul 15.
Protective immunity against enteric parasitic nematodes is dependent on IL-4, IL-13 activation of their exclusive transcription factor STAT6. The precise pathways by which enteric parasitic nematodes are recognized by the host is unclear, but elimination of this important interaction in developed na
PMID 26188364

Commentary: IL-4 and IL-13 receptors and signaling.

McCormick SM1, Heller NM2.
Cytokine.Cytokine.2015 Sep;75(1):38-50. doi: 10.1016/j.cyto.2015.05.023. Epub 2015 Jul 14.
Interleukin (IL)-4 and IL-13 were discovered approximately 30years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibro
PMID 26187331

Targeting of IL-4 and IL-13 receptors for cancer therapy.

Suzuki A1, Leland P2, Joshi BH3, Puri RK4.
Cytokine.Cytokine.2015 Sep;75(1):79-88. doi: 10.1016/j.cyto.2015.05.026. Epub 2015 Jun 15.
The Th2 cytokines, interleukin (IL)-4 and -13, are structurally and functionally related. They regulate immune responses and the immune microenvironment, not only under normal physiological conditions, but also in cancer. Both cytokines bind to their high-affinity receptors and form various configur
PMID 26088753

Japanese Journal

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling.

Nakajima Saeko,Igyártó Botond Z,Honda Tetsuya,Egawa Gyohei,Otsuka Atsushi,Hara-Chikuma Mariko,Watanabe Norihiko,Ziegler Steven F,Tomura Michio,Inaba Kayo,Miyachi Yoshiki,Kaplan Daniel H,Kabashima Kenji
The Journal of allergy and clinical immunology 129(4), 1048-1055.e6, 2012-04
… Methods: By using Langerin-diphtheria toxin receptor knock-in mice and human Langerin-diphtheria toxin A transgenic mice, we prepared mice deficient in LCs. … We also prepared mice deficient in TSLP receptors in LCs by using TSLP receptor–deficient mice with bone marrow chimeric technique. …
NAID 120004025593

Association of mast cell-derived VEGF and proteases in dengue shock syndrome

Furuta Takahisa,Murao Lyre Anni,Lan Nguyen Thi Phuong,Huy Nguyen Tien,Huong Vu Thi Que,Thuy Tran Thi,Tham Vo Dinh,Nga Cao Thi Phi,Ha Tran Thi Ngoc,Ohmoto Yasukazu,Kikuchi Mihoko,Morita Kouichi,Yasunami Michio,Hirayama Kenji,Watanabe Naohiro
PLoS Neglected Tropical Diseases 6(2), e1505, 2012-02-21
… To clarify the role of mast cells in the development of clinical Dengue fever, we compared the plasma levels of several mast cell-derived mediators (vascular endothelial cell growth factor [VEGF], soluble VEGF receptors [sVEGFRs], tryptase, and chymase) and -related cytokines (IL-4, -9, and -17) between patients with differing severity of Dengue fever and healthy controls. …
NAID 120004442177

「インターロイキン4受容体」

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Interleukin-4 receptor alpha chain, N-terminal
	interleukin-4 / receptor alpha chain complex
Identifiers
Symbol	IL4Ra_N
Pfam	PF09238
InterPro	IPR015319
SCOP	1iar
SUPERFAMILY	1iar
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

IL4R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IAR, 1IRS, 3BPL, 3BPN, 3BPO, 5E4E
Identifiers
Aliases	IL4R, CD124, IL-4RA, IL4RA, Interleukin-4 receptor, interleukin 4 receptor
External IDs	MGI: 105367 HomoloGene: 7784 GeneCards: IL4R
Gene location (Human)
Chr.	Chromosome 16 (human)
End	27,364,778 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	125,579,474 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• signal transducer activity, downstream of receptor; • protein binding; • cytokine receptor activity; • interleukin-4 receptor activity;
Cellular component	• integral component of membrane; • membrane; • receptor complex; • integral component of plasma membrane; • extracellular region; • extracellular space; • plasma membrane;
Biological process	• immune system process; • positive regulation of chemokine secretion; • positive regulation of immunoglobulin production; • positive regulation of macrophage activation; • positive regulation of mast cell degranulation; • response to estrogen; • production of molecular mediator involved in inflammatory response; • positive regulation of myoblast fusion; • negative regulation of T-helper 1 cell differentiation; • regulation of cell proliferation; • immunoglobulin mediated immune response; • immune response; • positive regulation of T-helper 2 cell differentiation; • ovulation; • signal transduction; • defense response to protozoan; • interleukin-4-mediated signaling pathway; • response to odorant; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3566
	16190
	ENSG00000077238
	ENSMUSG00000030748
	P24394
	P16382
	NM_000418; NM_001008699; NM_001257406; NM_001257407; NM_001257997
	NM_001008700; NM_001363983
	NP_000409; NP_001244335; NP_001244336; NP_001244926
	NP_001008700; NP_001350912
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: interleukin-4 receptor、IL-4 receptor
関: インターロイキン4レセプター、IL-4受容体、IL-4レセプター

「インターロイキン4レセプター」

　　[★]

英: interleukin-4 receptor、IL-4 receptor
関: インターロイキン4受容体、IL-4受容体、IL-4レセプター

「IL-4受容体」

　　[★]

英: IL-4 receptor
関: インターロイキン4受容体、インターロイキン4レセプター、IL-4レセプター

「IL-4レセプター」

　　[★]

英: IL-4 receptor
関: インターロイキン4受容体、インターロイキン4レセプター、IL-4受容体

「interleukin-4 receptor」

　　[★]

インターロイキン4受容体、インターロイキン4レセプター

関: IL-4 receptor、IL4 receptor

「I」

　　[★]

「IL」

　　[★]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077238 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030748 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[5] "Entrez Gene: IL4R interleukin 4 receptor".

[6] Thornhill, MH; Wellicome, SM; Mahiouz, DL; Lanchbury, JSS; Kyanaung, U; Haskard, DO (Jan 1991). "Tumor-necrosis-factor combines with IL-4 or IFN-gamma to selectively enhance endothelial-cell adhesiveness for T-cells-the contribution of vascular cell-adhesion molecule-1-dependent and molecule-1-independent binding mechanisms". Journal of Immunology. 146 (2): 592–598. PMID 1702807.

[pmid22974465-7] Tundup S, Srivastava L, Harn DA (April 2012). "Polarization of host immune responses by helminth-expressed glycans". Ann. N. Y. Acad. Sci. 1253: E1–E13. doi:10.1111/j.1749-6632.2012.06618.x. PMID 22974465.

[pmid10652211-8] Ikizawa K, Yanagihara Y (February 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. PMID 10652211.

[pmid11714803-9] Kashiwada M, Giallourakis CC, Pan PY, Rothman PB (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. 167 (11): 6382–7. doi:10.4049/jimmunol.167.11.6382. PMID 11714803.

[pmid10219247-10] Hage T, Sebald W, Reinemer P (April 1999). "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface". Cell. 97 (2): 271–81. doi:10.1016/S0092-8674(00)80736-9. PMID 10219247.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

リンク元	「インターロイキン4受容体」「インターロイキン4レセプター」「IL-4受容体」「IL-4レセプター」「interleukin-4 receptor」
関連記事	「I」「IL」

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案内

IL-4 receptor