English Journal

Characterization of β-adrenergic receptors in the heart chambers of adult turkeys.

Hoffmann S1, Müller T2, Abraham G3.
Veterinary journal (London, England : 1997).Vet J.2015 Jun;204(3):363-5. doi: 10.1016/j.tvjl.2015.02.016. Epub 2015 Feb 26.
The presence, distribution and characteristics of chamber-specific β-adrenergic receptors in adult turkey hearts were investigated by radioligand binding studies using (-)-[(125)I]-iodocyanopindolol (ICYP). The β1-selective (CGP 20712A) and β2-selective (ICI 118.551) antagonists as well as the no
PMID 25862393

[(18)F]-(fluoromethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)propan-2-ol ([(18)F FPTC) a novel PET-ligand for cerebral beta-adrenoceptors.

Mirfeizi L1, Rybczynska AA2, van Waarde A2, Campbell-Verduyn L3, Feringa BL3, Dierckx RA2, Elsinga PH2.
Nuclear medicine and biology.Nucl Med Biol.2014 Feb;41(2):203-9. doi: 10.1016/j.nucmedbio.2013.10.011. Epub 2013 Nov 7.
Cerebral β-adrenergic receptors (β-ARs) play important roles in normal brain and changes of β-AR expression are associated with several neuropsychiatric illnesses. Given the high density of β-AR in several brain regions, quantification of β-AR levels using PET is feasible. However, there is a l
PMID 24480269

Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists.

Sykes DA1, Charlton SJ.
British journal of pharmacology.Br J Pharmacol.2012 Apr;165(8):2672-83. doi: 10.1111/j.1476-5381.2011.01639.x.
BACKGROUND AND PURPOSE: β(2) -Adrenoceptor agonists are important bronchodilators used for the treatment of chronic obstructive pulmonary disease and asthma. Clinical data on β(2) -adrenoceptor agonists show a range of onset and duration of action. We have investigated whether the receptor binding
PMID 21883146

Japanese Journal

YAMAGUCHI IKUYO
The Kurume Medical Journal 40(3), 159-167, 1993
… specific [<SUP>125</SUP>I] iodocyanopindolol ([<SUP>125</SUP>I] ICYP) binding could be measured in the microdissected rat PCT. …
NAID 130000883316

Increased Uncoupling of β-, β1-and β2-Adrenoceptor to Myocardial Contraction in Failing Human Myocardium : CLINICAL EVALUATION OF CARDIAC PERFORMANCE

TAKAHASHI MASAYUKI,SHICHIRI GENSHOU,AMANO MOTOYA,KANAMORI TOSHIYUKI,KINOSHITA MASAHIKO
Japanese circulation journal 56(7), 701-709, 1992-07-20
… An α 1-AR agonist, methoxamine had little effect on myocardial contractility β -AR and α-AR densities were analyzed by saturation binding isotherms of myocardial membrane fraction with ^<125>I-Iodocyanopindolol (ICYP) and ^3H-Bunazosin, respectively. … β-1 and β2-ARs were separated by competition binding of ^<125>ICYP with a highly selective β1 AR antagonist, CGP20712A. …
NAID 110002587537