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1. 転移性ホルモン受容体陽性乳癌に対する治療アプローチ：内分泌療法 treatment approach to metastatic hormone receptor positive breast cancer endocrine therapy
2. 上皮性卵巣癌、卵管癌、または腹膜癌の再発に対する薬物療法：プラチナ製剤抵抗性癌 medical treatment for relapsed epithelial ovarian fallopian tubal or peritoneal cancer platinum resistant disease
3. エストロゲン作用の分子生物学および生理学 molecular biology and physiology of estrogen action
4. 男性における乳癌 breast cancer in men
5. 思春期早発症の治療 treatment of precocious puberty

Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling.

Nehybova T1, Smarda J2, Daniel L3, Brezovsky J3, Benes P4.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2015 Aug;152:76-83. doi: 10.1016/j.jsbmb.2015.04.019. Epub 2015 Apr 28.
Wedelolactone, a plant coumestan, was shown to act as anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase IIα. It is cytotoxic to breast, prostate, pituitary and myeloma cancer
PMID 25934092

Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1.

Bourque M1, Morissette M2, Di Paolo T3.
Neuropharmacology.Neuropharmacology.2015 Aug;95:343-52. doi: 10.1016/j.neuropharm.2015.04.006. Epub 2015 Apr 17.
We have previously shown that estrogen receptors (ER) α activation and G protein-coupled estrogen receptor 1 (GPER1) stimulation reproduce 17β-estradiol protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced toxicity of dopamine neurons in mice. This suggests that both ERα and GP
PMID 25892506

Raloxifene inhibits cloned Kv4.3 channels in an estrogen receptor-independent manner.

Chae YJ1, Kim DH, Lee HJ, Sung KW, Kwon OJ, Hahn SJ.
Pflügers Archiv : European journal of physiology.Pflugers Arch.2015 Aug;467(8):1663-76. doi: 10.1007/s00424-014-1602-3. Epub 2014 Sep 18.
Raloxifene is widely used for the treatment and prevention of postmenopausal osteoporosis. We examined the effects of raloxifene on the Kv4.3 currents expressed in Chinese hamster ovary (CHO) cells using the whole-cell patch-clamp technique and on the long-term modulation of Kv4.3 messenger RNA (mRN
PMID 25231973