WordNet
- strike with horror or terror; "The news of the bombing shocked her"
- (pathology) bodily collapse or near collapse caused by inadequate oxygen delivery to the cells; characterized by reduced cardiac output and rapid heartbeat and circulatory insufficiency and pallor; "loss of blood is an important cause of shock"
- subject to electrical shocks
- the violent interaction of individuals or groups entering into combat; "the armies met in the shock of battle" (同)impact
- an unpleasant or disappointing surprise; "it came as a shock to learn that he was injured" (同)blow
- an instance of agitation of the earths crust; "the first shock of the earthquake came shortly after noon while workers were at lunch" (同)seismic disturbance
- a bushy thick mass (especially hair); "he had an unruly shock of black hair"
- a pile of sheaves of grain set on end in a field to dry; stalks of Indian corn set up in a field; "corn is bound in small sheaves and several sheaves are set up together in shocks"; "whole fields of wheat in shock"
- surprise greatly; knock someones socks off; "I was floored when I heard that I was promoted" (同)floor, ball over, blow out of the water, take aback
- strike with disgust or revulsion; "The scandalous behavior of this married woman shocked her friends" (同)offend, scandalize, scandalise, appal, appall, outrage
- collect or gather into shocks; "shock grain"
- collide violently
- provide with heat; "heat the house"
- a form of energy that is transferred by a difference in temperature (同)heat energy
- make hot or hotter; "the sun heats the oceans"; "heat the water on the stove" (同)heat_up
- gain heat or get hot; "The room heated up quickly" (同)hot up, heat_up
- the trait of being intensely emotional (同)warmth, passion
- the sensation caused by heat energy (同)warmth
- a preliminary race in which the winner advances to a more important race
- the 5th letter of the Hebrew alphabet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- marked by emotional heat; vehement; "a heated argument"
- made warm or hot (`het is a dialectal variant of `heated' (同)heated up, het, het_up
PrepTutorEJDIC
- 〈C〉(衝突・爆発などの)『衝撃』,(地震の)震動,電撃 / 〈C〉〈U〉(精神的)『打撃』,ショック / 〈U〉ショック症 / 《しばしば受動態で》〈人〉‘を'『ぎょっとさせる』,ひどく驚かせる / (治療のため)〈人・動物〉‘に'電気ショクを与える
- (乾燥させるために立てかけた)穀類の刈り束 / 〈穀類〉‘を'刈り束にする
- (髪の毛の)もじゃもじゃの固まり《+『of』+『名』》
- 〈U〉『熱さ』,『暑さ』,熱い状態 / 〈U〉熱度,温度 / 〈U〉(家などの)暖房装置 / 〈U〉熱心,熱烈;(物事の)最高潮《+『of』+『名』》 / 〈U〉(エネルギーとしての)熱 / 〈C〉(競技の)1回,1ラウンド / …‘を'『熱する』,暖める《+『up』+『名,』+『名』+『up』》 / …‘を'興奮させる,怒らせる《+『up』+『名,』+『名』+『up』》 / 熱くなる,暖まる《+『up』》
- （雌の）発情（in heatとして使う）・金・銭・緊迫、プレッシャー、批判、批評、警察の追跡
- 彼は,彼が / 《指す人の性別が分からないか,または分かる必要のない場合に》その人,あの人,自分 / 《he who(that)の形で》《文》…するものはだれでも / (動物の)おす(雄)
- 鬼ごっこ(tag,tick,tig)
- 蛋白(たんばく)質
- 熱せられた / 興奮した,怒った
UpToDate Contents
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- 1. 骨形成不全症：臨床的特徴および診断 osteogenesis imperfecta clinical features and diagnosis
- 2. 関節リウマチの疫学、危険因子、および可能性のある原因 epidemiology of risk factors for and possible causes of rheumatoid arthritis
- 3. ベーチェット病の病因 pathogenesis of behcets disease
- 4. 筋萎縮性側索硬化症の病態修飾療法 disease modifying treatment of amyotrophic lateral sclerosis
- 5. 若年性特発性関節炎：疫学と免疫病態学 juvenile idiopathic arthritis epidemiology and immunopathogenesis
English Journal
- Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma.
- Yamamoto N, Kinoshita T, Nohata N, Yoshino H, Itesako T, Fujimura L, Mitsuhashi A, Usui H, Enokida H, Nakagawa M, Shozu M, Seki N.Author information Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan.AbstractOur recent studies of microRNA (miRNA) expression signatures indicated that microRNA-29a (miR-29a) was significantly downregulated in several types of human cancers, suggesting that miR-29a may be a putative tumor-suppressive miRNA in human cancers. The aim of this study was to investigate the functional significance of miR-29a in cervical squamous cell carcinoma (SCC) and to identify novel miR-29a-regulated cancer pathways and target genes involved in cervical SCC oncogenesis and metastasis. Restoration of miR-29a in cervical cancer cell lines (CaSKi, HeLa, ME180 and Yumoto) revealed that this miRNA significantly inhibited cancer cell migration and invasion. Gene expression data and in silico analysis demonstrated that heat-shock protein 47 (HSP47), a member of the serpin superfamily of serine proteinase inhibitors and a molecular chaperone involved in the maturation of collagen molecules, was a potential target of miR-29a regulation. Luciferase reporter assays showed that miR-29a directly regulated HSP47. Moreover, silencing of the HSP47 gene significantly inhibited cell migration and invasion in cancer cells and the expression of HSP47 was upregulated in cancer tissues and cervical intraepithelial neoplasia (CIN), as demonstrated by immunostaining. Downregulation of miR-29a was a frequent event in cervical SCC and miR-29a acted as a tumor suppressor by directly targeting HSP47. Recognition of tumor-suppressive miRNA-regulated molecular targets provides new insights into the potential mechanisms of cervical SCC oncogenesis and metastasis and suggests novel therapeutic strategies for treatment of this disease.
- International journal of oncology.Int J Oncol.2013 Dec;43(6):1855-63. doi: 10.3892/ijo.2013.2145. Epub 2013 Oct 18.
- Our recent studies of microRNA (miRNA) expression signatures indicated that microRNA-29a (miR-29a) was significantly downregulated in several types of human cancers, suggesting that miR-29a may be a putative tumor-suppressive miRNA in human cancers. The aim of this study was to investigate the funct
- PMID 24141696
- Serum heat shock protein 47 levels in patients with drug-induced lung disease.
- Kakugawa T, Yokota S, Ishimatsu Y, Hayashi T, Nakashima S, Hara S, Sakamoto N, Matsuoka Y, Kubota H, Mine M, Mukae H, Nagata K, Kohno S.Author information Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. kakugawa@nagasaki-u.ac.jp.AbstractBACKGROUND: Heat shock protein (HSP) 47 is a collagen-specific molecular chaperone that is required for molecular maturation of various types of collagens. We recently reported that HSP47 serum levels were markedly higher in patients with acute exacerbations of idiopathic pulmonary fibrosis (IPF) when compared with patients with stable IPF, suggesting that serum HSP47 levels correlate with interstitial pneumonia activity. The aim of this study was to evaluate serum HSP47 levels in patients with drug-induced lung disease (DILD).
- Respiratory research.Respir Res.2013 Nov 20;14:133. doi: 10.1186/1465-9921-14-133.
- BACKGROUND: Heat shock protein (HSP) 47 is a collagen-specific molecular chaperone that is required for molecular maturation of various types of collagens. We recently reported that HSP47 serum levels were markedly higher in patients with acute exacerbations of idiopathic pulmonary fibrosis (IPF) wh
- PMID 24256690
- Gingival tissue healing following Er:YAG laser ablation compared to electrosurgery in rats.
- Sawabe M, Aoki A, Komaki M, Iwasaki K, Ogita M, Izumi Y.Author information Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.AbstractThe erbium-doped yttrium aluminum garnet (Er:YAG) laser is currently used for periodontal soft tissue management with favorable outcomes. However, the process of wound healing after Er:YAG laser (ErL) treatment has not been fully elucidated yet. The aim of this study was to investigate the gingival tissue healing after ErL ablation in comparison with that after electrosurgery (ElS). Gingival defects were created in 28 rats by ablation with ErL irradiation or ElS. The chronological changes in wound healing were evaluated using histological, histometrical, and immunohistochemical analyses. The ErL-ablated gingival tissue revealed much less thermal damage, compared to the ElS. In the ElS sites, the postoperative tissue destruction continued due to thermal damage, while in the ErL sites, tissue degradation was limited and the defects were re-epithelialized early. Heat shock protein (Hsp) 72/73 expression was detected abundantly remote from the wound in the ElS, whereas it was slightly observed in close proximity to the wound in the ErL sites. Hsp47 expression was observed in the entire connective tissue early in the wound healing and was found limited in the wound area later. This phenomenon proceeded faster in the ErL sites than in the ElS sites. Expression of proliferating cell nuclear antigen (PCNA) persisted in the epithelial tissue for a longer period in the ElS than that in the ErL. The ErL results in faster and more favorable gingival wound healing compared to the ElS, suggesting that the ErL is a safe and suitable tool for periodontal soft tissue management.
- Lasers in medical science.Lasers Med Sci.2013 Nov 16. [Epub ahead of print]
- The erbium-doped yttrium aluminum garnet (Er:YAG) laser is currently used for periodontal soft tissue management with favorable outcomes. However, the process of wound healing after Er:YAG laser (ErL) treatment has not been fully elucidated yet. The aim of this study was to investigate the gingival
- PMID 24241972
Japanese Journal
- Antistress Effects of the Ethanolic Extract from Cymbopogon schoenanthus Growing Wild in Tunisia
- Othman Mahmoud Ben,Han Junkyu,Omri Abdelfatteh El,Ksouri Riadh,Neffati Mohamed,Isoda Hiroko,韓 畯奎,礒田 博子
- Evidence-based complementary and alternative medicine 2013, 737401, 2013
- … Its effect on stress-induced in ICR mice was exposed to force swim and tail suspension, in concordance with heat shock protein expression (HSP27 and HSP90), corticosterone, and catecholamine neurotransmitters level. …
- NAID 120005345628
- Production and degradation of extracellular matrix in reversible glomerular lesions in rat model of habu snake venom-induced glomerulonephritis
- Kawazu Tayo,Nishino Tomoya,Obata Yoko,Furusu Akira,Miyazaki Masanobu,Abe Katsushige,Koji Takehiko,Kohno Shigeru
- Medical Molecular Morphology 45(4), 190-198, 2012-12
- … Renal tissue was isolated and subjected to immunohistochemical analysis for expression levels of type IV collagen, heat shock protein 47 (HSP47), transforming growth factor-β (TGF-β), and matrix metalloproteinase-3 (MMP-3), as well as its transcription factor Ets-1. … Expression levels of HSP47, TGF-β, and type IV collagen began to increase in the mesangial area starting from day 14 and peaked on day 21, followed by a gradual decrease. …
- NAID 120005322494
- Assessment of wastewater-irrigated soil containing heavy metals and establishment of specific biomarkers
- Fredj F. Ben,Han J.,Irie M.,Funamizu N.,Ghrabi A.,Isoda H.,入江 光輝,礒田 博子
- Ecotoxicology and environmental safety 84, 54-62, 2012-10
- … The heat shock protein (HSP) 47, E-screen, and transepithelial electrical resistance (TEER) assays served to investigate the stress response of treated-HSP47-transfected Chinese hamster ovary (CHO) cells, the estrogenic activity of the samples in MCF-7 breast cancer cells, and the barrier function (BF) of Caco-2 cells. …
- NAID 120004898310
Related Links
- Heat shock proteins (HSPs) are part of a highly conserved genetic survival system originally discovered by Ferruccio Ritossa in 1962 (Ritossa, Riv Ist Sieroter ... Pratt WB, Toft DO (2003) Regulation of signaling protein function and ...
- Pancreatic Cancer Translational Research Group, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW2052 ... Abstract Heat shock proteins (HSPs) are part of a highly ...
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★リンクテーブル★
| リンク元 | 「Hsp47熱ショックタンパク質」 |
| 関連記事 | 「heat」「heat shock」「shock」「heating」「Hsp」 |
「Hsp47熱ショックタンパク質」
「heat」
- n.
- v.
- 加熱する、加温する
「heat shock」
「shock」
「heating」
- n.