Heinz bodies

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/02 18:27:39」(JST)

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  • Rsu1 regulates ethanol consumption in Drosophila and humans.
  • Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Büchel C, Bokde AL, Carvalho F, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lubbe S, Martinot JL, Paus T, Smolka MN, Spanagel R, O'Reilly PF, Laitinen J, Veijola JM, Feng J, Desrivières S, Jarvelin MR; IMAGEN Consortium, Schumann G, Rothenfluh A.
  • Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Jul 13. pii: 201417222. [Epub ahead of print]
  • Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We show that Rsu1 is required in the adu
  • PMID 26170296
  • Reply to: Heinz bodies and erythrophagocytosis in the peripheral blood of loggerhead sea turtles.
  • Pica A1.
  • Journal of experimental zoology. Part A, Ecological genetics and physiology.J Exp Zool A Ecol Genet Physiol.2015 Jun;323(6):345-8. doi: 10.1002/jez.1927. Epub 2015 Mar 16.
  • PMID 25777541
  • Letter to the Editor: Heinz bodies and erythrophagocytosis in the peripheral blood of loggerhead sea turtles.
  • Stacy NI1, Harvey JW2.
  • Journal of experimental zoology. Part A, Ecological genetics and physiology.J Exp Zool A Ecol Genet Physiol.2015 Jun;323(6):343-4. doi: 10.1002/jez.1925. Epub 2015 Mar 16.
  • PMID 25777323


  • Heinz小体の出現を伴う一過性溶血発作を呈した極低出生体重児10例の経験
  • 熊坂 栄,島 義雄,中島 瑞恵 [他],右田 真
  • 日本医科大学医学会雑誌 7(1), 16-19, 2011
  • … We report on 10 premature infants with acute hemolytic anemia and Heinz bodies treated from 1999 to 2007 and discuss their clinical characteristics. … Heinz body appeared an average of 20 days after birth (range, 1125 days), and hemolysis persisted for an average of 9 days (range, 416 days) and spontaneously resolved. … Hemolytic anemia and jaundice developed suddenly, during which time Heinz bodies were observed on hematologic examination. …
  • NAID 130004941967
  • Hypertension after Ingestion of Baked Garlic (Allium sativum) in a Dog
  • Kang Min-Hee,Park Hee-Myung
  • Journal of Veterinary Medical Science 72(4), 515-518, 2010
  • … Eccentrocytes, Heinz bodies and ruptured red blood cells were also noted on blood smear films, which were the results from the oxidative injury of the Allium species. …
  • NAID 130000149952
  • Verapamil Prevents Impairment in Filterability of Human Erythrocytes Exposed to Oxidative Stress
  • Okamoto Kazuhiko,Maruyama Toru,Kaji Yoshikazu,Harada Mine,Mawatari Shiro,Fujino Takehiko,Uyesaka Nobuhiro
  • The Japanese Journal of Physiology 54(1), 39-46, 2004
  • … Erythrocytes exposed to tBHP also show an increase in mean corpuscular volume and a remarkable formation of methemoglobin (met-Hb) without any appearance of hemichromes that form Heinz bodies. …
  • NAID 130004435889


Heinz bodies appear as small round inclusions within the red cell body, though they are not visible when stained with Romanowsky dyes. They appear more clearly when supravitally stained [5] (e.g., with new methylene blue or bromocresol green
Heinz bod·ies (hīnz), intracellular inclusions usually attached to the red blood cell membrane, composed of denatured hemoglobin; they occur in thalassemia, enzymopathies, hemoglobinopathies, and after splenectomy. Visualization ...






Heinz body

  • 後期赤芽球~赤血球に存在する
  • 酸化変性したヘモグロビン塊である。
  • 末梢血のメチル紫超生体染色、あるいはブリリアント緑による染色でみられる。
  • 正常赤血球でも小型の塊が1~6個ほど観察される (BCAT.95)
  • ヘモグロビンの形成異常、代謝酵素の欠損、薬物などによる変性の際に認められる。
  • 不安定ヘモグロビン症では大きなハインツ小体が観察される。
  • グルコース-6-リン酸脱水素酵素異常症(G6PD欠乏症)では正常より多数のハインツ小体を見る。
  • ハインツ小体は赤血球膜に結合して、赤血球の弾性を低下させる。
  • ハインツ小体を有する赤血球は、脾臓にてハインツ小体を有する部分のみ(細網により)取り除かれるが、溶血により循環から取り除かれる運命を辿る。


  • 1. 写真



WordNet   license wordnet

「United States industrialist who manufactured and sold processed foods (1844-1919)」
Henry John Heinz