WordNet
- a diuretic drug (trade name Microzide, Esidrix, and HydroDIURIL) used in the treatment of hypertension (同)Microzide, Esidrix, HydroDIURIL
UpToDate Contents
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- 1. 原発性（本態性）高血圧における治療選択：推奨 choice of therapy in primary essential hypertension recommendations
- 2. 乳児および小児における心不全のマネージメント management of heart failure in infants and children
- 3. 原発性（本態性）高血圧患者におけるサイアザイド系利尿薬の使用 use of thiazide diuretics in patients with primary essential hypertension
- 4. 成人における再発性カルシウム結石の予防 prevention of recurrent calcium stones in adults
- 5. 原発性（本態性）高血圧における治療選択：臨床試験 choice of therapy in primary essential hypertension clinical trials
English Journal
- Low level drug product API form analysis - Avalide tablet NIR quantitative method development and robustness challenges.
- Pan D1, Crull G2, Yin S2, Grosso J2.Author information 1Drug Product Science & Technology, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, NJ 08903, United States. Electronic address: duohai.pan@bms.com.2Drug Product Science & Technology, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, NJ 08903, United States.AbstractAvalide(@), a medication used for the treatment of hypertension, is a combination of Irbesartan, and Hydrochlorothiazide. Irbesartan, one of the active pharmaceutical ingredients (API) in Avalide products, exists in two neat crystalline forms: Form A and Form B. Irbesartan Form A is the API form used in a wet granulation for the preparation of Avalide tablets. The presence of the less soluble Irbesartan Form B in Avalide tablets may result in the slower dissolution. In this paper, we have presented our work on the method development, verification and challenges of quantitatively detecting, via NIR and ssNMR, very small amounts of Irbesartan Form B in Avalide tablets. As part of the NIR method development and qualification, limit of detection, linearity and accuracy were examined. In addition, a limited study of the robustness of the method was conducted and a bias in the level of Form B was correlated to the ambient humidity. ssNMR, a primary method for the determination of polymorphic composition, was successfully used as an orthogonal technique to verify the accuracy of the NIR method and added to the confidence in the NIR method. The speed and efficiency of the NIR method make it a suitable and convenient tool for routine analysis of Avalide tablets for Form B in a QC environment.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2014 Feb 15;89:268-75. doi: 10.1016/j.jpba.2013.11.011. Epub 2013 Nov 20.
- Avalide(@), a medication used for the treatment of hypertension, is a combination of Irbesartan, and Hydrochlorothiazide. Irbesartan, one of the active pharmaceutical ingredients (API) in Avalide products, exists in two neat crystalline forms: Form A and Form B. Irbesartan Form A is the API form use
- PMID 24316453
- An eco-friendly strategy, using on-line monitoring and dilution coupled to a second-order chemometric method, for the construction of dissolution curves of combined pharmaceutical associations.
- Calvo NL1, Maggio RM1, Kaufman TS2.Author information 1Pharmaceutical Analysis, Department of Organic Chemistry, School of Pharmaceutical and Biochemical Sciences, National University of Rosario and Institute of Chemistry of Rosario (IQUIR, CONICET-UNR), Suipacha 531, Rosario S2002LRK, Argentina.2Pharmaceutical Analysis, Department of Organic Chemistry, School of Pharmaceutical and Biochemical Sciences, National University of Rosario and Institute of Chemistry of Rosario (IQUIR, CONICET-UNR), Suipacha 531, Rosario S2002LRK, Argentina. Electronic address: kaufman@iquir-conicet.gov.ar.AbstractA simple, precise, economic and minimally operator-dependent method was developed under green analytical chemistry principles, for the simultaneous construction of the dissolution curves of a pharmaceutical association in short time and without employing organic solvents, allowing important savings of labor and resources. The carvedilol (CAR) and hydrochlorothiazide (HCT) combined formulation was employed as a model. The method (OD/UV-MCR) involves on-line sample dilution (OD) and UV detection of the analytes, coupled to multivariate curve resolution with alternating least squares (MCR-ALS). OD/UV-MCR proved to be robust and was successfully validated in accordance to ICH guidelines, fulfilling acceptance criteria for specificity (r(2) of spectral correlation>0.950), linearity [r>0.999 (N=25) in the ranges 1.00-31.1mgl(-1) and 0.51-15.2mgl(-1) for CAR and HCT, respectively] and precision (RSD<2%). Accuracy was assessed by point-to-point comparison between the dissolution profiles furnished by the proposed method with those provided by HPLC analysis, evidencing the usefulness of this monitoring system. In addition, OD/UV-MCR was successfully employed for the comparative analysis of three lots of commercial formulations of the CAR-HCT pharmaceutical association, belonging to a couple of different brands, employing Moore and Flanner's f2 similarity indicator.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2014 Feb 15;89:213-20. doi: 10.1016/j.jpba.2013.10.043. Epub 2013 Nov 9.
- A simple, precise, economic and minimally operator-dependent method was developed under green analytical chemistry principles, for the simultaneous construction of the dissolution curves of a pharmaceutical association in short time and without employing organic solvents, allowing important savings
- PMID 24291800
- Aliskiren/Amlodipine vs. Aliskiren/Hydrochlorothiazide in Hypertension: Indirect Meta-Analysis of Trials Comparing the Two Combinations vs. Monotherapy.
- Liu Y, Yan R, Song A, Niu X, Cao C, Wei J, Dong X, Gao D.Author information Department of Cardiology, the Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, P.R. China.AbstractBACKGROUND: Aliskiren, a direct renin inhibitor, is effective for reducing blood pressure (BP) in patients with hypertension when combined with amlodipine or hydrochlorothiazide (HCTZ). However, the efficacy and tolerability of the 2 combinations are unclear. We performed a meta-analysis of randomized controlled trials of aliskiren/amlodpine and aliskiren/HCTZ for hypertension.
- American journal of hypertension.Am J Hypertens.2014 Feb;27(2):268-78. doi: 10.1093/ajh/hpt210. Epub 2013 Dec 4.
- BACKGROUND: Aliskiren, a direct renin inhibitor, is effective for reducing blood pressure (BP) in patients with hypertension when combined with amlodipine or hydrochlorothiazide (HCTZ). However, the efficacy and tolerability of the 2 combinations are unclear. We performed a meta-analysis of randomiz
- PMID 24304656
Related Links
- Physician reviewed HydroDIURIL patient information - includes HydroDIURIL description, dosage and directions.
- Find patient medical information for HydroDiuril Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
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