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hydroperoxyeicosatetraenoic acid
See Hydroperoxides
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  • Tandem mass spectrometry analysis of linoleic and arachidonic acid hydroperoxides via promotion of alkali metal adduct formation.
  • Ito J1, Mizuochi S1, Nakagawa K1, Kato S1, Miyazawa T1.
  • Analytical chemistry.Anal Chem.2015 May 5;87(9):4980-7. doi: 10.1021/acs.analchem.5b00851. Epub 2015 Apr 24.
  • Recently, we demonstrated that tandem mass spectrometry (MS/MS) analysis in the presence of sodium ions was useful for identification of the position of the hydroperoxy group in phosphatidylcholine hydroperoxide (PCOOH). Likewise, MS/MS may enable identification of the hydroperoxy group position in
  • PMID 25874840
  • Impact of myeloperoxidase-derived oxidants on the product profile of human 5-lipoxygenase.
  • Zschaler J1, Dorow J2, Schöpe L3, Ceglarek U2, Arnhold J4.
  • Free radical biology & medicine.Free Radic Biol Med.2015 Apr 22;85:148-156. doi: 10.1016/j.freeradbiomed.2015.04.015. [Epub ahead of print]
  • Human 5-lipoxygenase (5-LOX) oxidizes arachidonic acid to 5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HpETE) and leukotriene (LT) A4. In neutrophils, LTA4 is further converted to the potent chemoattractant LTB4. These cells also contain the heme enzyme myeloperoxidase (MPO), which produces
  • PMID 25912480
  • Mutagenesis of triad determinants of rat Alox15 alters the specificity of fatty acid and phospholipid oxygenation.
  • Pekárová M1, Kuhn H2, Bezáková L3, Ufer C2, Heydeck D4.
  • Archives of biochemistry and biophysics.Arch Biochem Biophys.2015 Apr 1;571:50-7. doi: 10.1016/j.abb.2015.02.029. Epub 2015 Feb 27.
  • Among lipoxygenases ALOX15 orthologs are somewhat peculiar because of their capability of oxygenating polyenoic fatty acids even if they are incorporated in complex lipid-protein assemblies. ALOX15 orthologs of different species have been characterized before, but little is known about the correspon
  • PMID 25731857


  • High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade.
  • Okada Yukio,Imendra Kotapola G,Miyazaki Toshihiro,Hotokezaka Hitoshi,Fujiyama Rie,Toda Kazuo
  • PLoS One 6(4), e19158, 2011-04-29
  • … IP(3) dialysis failed to induce conductance increase, but 2-arachidonoylglycerol (2-AG), arachidonic acid and 12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HPETE) dialysis increased the conductance identical to extracellular Ca(2+)-induced conductance. …
  • NAID 120003238497
  • Role of Leukotriene B4 in 5-Lipoxygenase Metabolite- and Allergy-Induced Itch-Associated Responses in Mice
  • Tsuji Fumio,Aono Hiroyuki,Tsuboi Takashi [他],Murakami Tadahiro,Enomoto Hiroshi,Mizutani Keiko,Inagaki Naoki
  • Biological and Pharmaceutical Bulletin 33(6), 1050-1053, 2010
  • … Itch-associated responses were induced by intradermal injection of 5-hydroperoxyeicosatetraenoic acid (HPETE), a precursor of 5-lipoxygenase metabolites, and passive cutaneous anaphylaxis in ICR mice. … 5-HPETE induced scratching behavior, which was inhibited by SA6541 (100 mg/kg). … However, SA6541 (100 mg/kg) hardly attenuated the 5-HPETE-induced increase in vascular permeability. …
  • NAID 130000247978
  • Detection of 5-Lipoxygenase Activity in the Liverwort Marchantia polyrnorpha L.
  • Kanamoto Hirosuke,Takemura Miho,Ohyama Kanji
  • Bioscience, biotechnology, and biochemistry 73(11), 2549-2551, 2009-11-23
  • … LC/MS/MS analysis indicated that the liverwort 5-LOX produced 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid (5-HPETE) with arachidonic acid as a substrate. …
  • NAID 10027548337


アラキドン酸から5-LOと12/15-LOの協調作用により5-HPETE(5-ヒドロペルオキシ エイコサテトラエン酸)を経て産生されるLXA2 ... NADPHオキシダーゼ活性化や酸化 ストレスの存在下で5-HPETEから生じる中間体5-oxo-エイコサテトラエン酸(ETE)は、 その ...


HpETEFigure 1 Prostaglandin synthesis. (HPETE  Ácido aracdônico 5-HPETE Leucotrieno A4HETE and HPETE biosynthesis and metabolism15(S)- HpETE




5-hydroperoxyeicosatetraenoic acid

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