- 同
- medrysone
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/14 01:25:28」(JST)
[Wiki en表示]
Medrysone
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Systematic (IUPAC) name |
(6S,8S,9S,10R,11S,13R,14S,17S)- 17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,
11,12,14,15,16,17- dodecahydrocyclopenta[a] phenanthren-3-one
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Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
MedlinePlus |
a606003 |
Pregnancy
category |
- US: C (Risk not ruled out)
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Legal status |
|
Routes of
administration |
Eye drops |
Identifiers |
CAS Registry Number |
2668-66-8 Y |
ATC code |
S01BA08 |
PubChem |
CID: 247839 |
IUPHAR/BPS |
7086 |
DrugBank |
DB00253 N |
ChemSpider |
216968 N |
UNII |
D2UFC189XF N |
KEGG |
D02289 Y |
ChEMBL |
CHEMBL1201173 N |
Chemical data |
Formula |
C22H32O3 |
Molecular mass |
344.488 g/mol |
SMILES
-
C[C@H]1C[C@H]2[C@@H]3CC[C@@H]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)CC4)C)O)C)C(=O)C
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InChI
-
InChI=1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1 N
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Key:GZENKSODFLBBHQ-ILSZZQPISA-N N
|
N (what is this?) (verify) |
Medrysone is a corticosteroid that has been used in optometry[citation needed], and in ophthalmology for the treatment of eye inflammations.[1][2] It has been discontinued in the US.[2]
See also
References
- ^ Rastogi, R. K.; Mathur, A.; Raizada, I. N. (1985). "Efficacy of medrysone as anti-inflammatory agent". Indian journal of ophthalmology 33 (5): 295–297. PMID 3843339. edit
- ^ a b Medrysone Micromedex Detailed Consumer Information
Glucocorticoids and antiglucocorticoids (H02)
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|
Agonists |
Pregnene |
|
|
Pregnenedione |
- Hydrocortisone (cortisol)# (Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate)
- Budesonide
- Ciclesonide
- Deflazacort
- Medrysone
- Tixocortol
- HALOGENATED AT 6: Cloprednol
- HALOGENATED, WITH FG AT 16: Halcinonide
|
|
Pregnadiene |
- Rimexolone
- HALOGENATED, WITH FG AT 16: Flunisolide
- Triamcinolone
- Amcinonide
- Fluocinolone acetonide (Fluocinonide)
|
|
Pregnadienediol |
- Prednisone (Meprednisone)
- HALOGENATED AT 9: Fluorometholone
- HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone
- Diflucortolone
- Fluocortin)
- Desoximetasone
|
|
Pregnadienetriol |
- Prednisolone# (Methylprednisolone
- Methylprednisolone aceponate
- Prednicarbate
- Prednylidene)
- Desonide
- HALOGENATED: Fluprednisolone (Difluprednate
- Fluperolone)
- HALOGENATED, WITH FG AT 16: Dexamethasone#
- Betamethasone (Clobetasol
- Clobetasone
- Diflorasone
- Halometasone
- Ulobetasol)
- Beclometasone
- Paramethasone
- Alclometasone
- Fluclorolone acetonide
- Flumetasone
- Fluprednidene
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Pregnatriene |
|
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Androstene |
- HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate
- Fluticasone furoate)
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Others/unsorted |
- HALOGENATED: Loteprednol
- HALOGENATED, WITH FG AT 16: Fludroxycortide
- Formocortal
- Mometasone furoate
- Promestriene
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|
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Antagonists /
SGRMs |
- Antagonists: Ketoconazole
- Mifepristone
|
|
Synthesis modifiers |
- Acetoxolone
- Aminoglutethimide
- Carbenoxolone
- Enoxolone
- Ketoconazole
- Metyrapone
- Mitotane
- Trilostane
|
|
-
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of hormones
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|
Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
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Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
|
|
Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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Glucocorticoid signaling
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Receptor
(ligands) |
GR
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Agonists
|
|
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Mixed (SEGRAs)
|
- Dagrocorat
- Fosdagrocorat
- Mapracorat
|
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Antagonists
|
- 3α-Hydroxytibolone
- 3β-Hydroxytibolone
- Aglepristone
- Asoprisnil
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Ketoconazole
- Lilopristone
- LLY-2707
- Miconazole
- Mifepristone
- Onapristone
- Org 34850
- PCN
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
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Enzyme
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Modulators
|
- 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, 11β-HSD, 21-hydroxylase, 11β-hydroxylase, and 18-hydroxylase) (see also Steroid hormone metabolism modulators)
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Others |
Precursors/prohormones
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- Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- Pregnenolone sulfate
- 17-Hydroxypregnenolone
- Progesterone
- 17-Hydroxyprogesterone
- 11-Deoxycorticosterone
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Indirect
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- ACTH (corticotropin)
- CRH
- DHEA
- DHEA sulfate
- Plasma proteins (albumin, transcortin)
- Vasopressin
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|
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See also: Androgenics • Estrogenics • Mineralocorticoids • Progestogenics
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UpToDate Contents
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English Journal
- [Effects of electroacupuncture of Sanyinjiao (SP 6) on genito-endocrine in patients with perimenopausal syndrome].
- Qin ZY, Ling H, Xia XH, Meng L, Wu ZJ.SourceClinical School of Acu-moxibustion, Osteology and Traumatology, Anhui College of Chinese Medicine, Hefei 230038, China.
- Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji].Zhen Ci Yan Jiu.2007 Aug;32(4):255-9.
- OBJECTIVE: To observe the regulative effect of electroacupuncture (EA) of Sanyinjiao (SP 6) on genito-endocrine in patients with perimenopausal syndrome (PMS).METHODS: A total of 175 PMS patients (157 cases with complete data) were randomized into EA group (n=81) and medication group (n=76) accordin
- PMID 17907389
- Behavioral and neurochemical effects on rat offspring after prenatal exposure to ethanol.
- Carneiro LM, Diógenes JP, Vasconcelos SM, Aragão GF, Noronha EC, Gomes PB, Viana GS.SourceDepartment of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Cel. Nunes de Melo, 1127, Fortaleza 60430-270, Brazil.
- Neurotoxicology and teratology.Neurotoxicol Teratol.2005 Jul-Aug;27(4):585-92.
- The work studied behavioral and neurochemical alterations in 21-day-old pups, from both sexes (26 g on average) born from female Wistar rats administered daily with ethanol (0.5 or 4.0 g/kg, p.o.), for 30 days before mating, and throughout their gestational period. Ethanol administration continued f
- PMID 16039829
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