WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 8th letter of the Roman alphabet (同)h

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蛋白(たんばく)質
hydrogenの化学記号
鉛筆の硬度 / 《俗》heroin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/03 00:25:07」(JST)

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High-Mobility Group or HMG is a group of chromosomal proteins that are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair.^[1]

Families

The HMG proteins are subdivided into 3 superfamilies each containing a characteristic functional domain:

HMGA – contains an AT-hook domain
- HMGA1
- HMGA2

HMGB – contains a HMG-box domain
- HMGB1
- HMGB2
- HMGB3
- HMGB4

HMGN – contains a nucleosomal binding domain
- HMGN1
- HMGN2
- HMGN3
- HMGN4

Sex-Determining Region Y Protein

TCF Transcription Factors
- Lymphoid enhancer-binding factor 1
- T Cell Transcription Factor 1

Proteins containing any of these embedded in their sequence are known as HMG motif proteins. HMG-box proteins are found in a variety of eukaryotic organisms.

They were originally isolated from mammalian cells, and named according to their electrophoretic mobility in polyacrylamide gels.^[2]

Function

HMG proteins are thought to play a significant role in various human disorders. Disruptions and rearrangements in the genes coding for some of the HMG proteins are associated with some common benign tumors. Antibodies to HMG proteins are found in patients suffering from autoimmune diseases. The SRY gene on the Y Chromosome, responsible for male sexual differentiation, contains an HMG-Box domain. A member of the HMG family of proteins, HMGB1, has also been shown to have an extracellular activity as a chemokine, attracting neutrophils and mononuclear inflammatory cells to the infected liver.^[3]

References

^ Rajeswari MR, Jain A (2002). "High-mobility-group chromosomal proteins, HMGA1 as potential tumour markers" (PDF). Current Science 82 (7): 838–844.
^ Johns EB (1982). The HMG chromosomal proteins. Boston: Academic Press. ISBN 0-12-386050-4.
^ Sitia G, Iannacone M, Müller S, Bianchi ME, Guidotti LG (January 2007). "Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice". J. Leukoc. Biol. 81 (1): 100–7. doi:10.1189/jlb.0306173. PMID 16935945.

External links

HMG nomenclature home page
High Mobility Group Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

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