HHV-8

出典: meddic

ヒトヘルペスウイルス8型, human herpes virus 8, human herpesvirus-8

Kaposi sarcoma-associated herpesvirusKaposi's sarcoma-associated herpesvirusKSHV

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/03/19 08:26:12」(JST)

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英文文献

  • Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.
  • Cousins E, Nicholas J.Author information Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Baltimore, MD, 21287, USA, ecousins@jhmi.edu.AbstractHuman herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the second identified human gammaherpesvirus. Like its relative Epstein-Barr virus, HHV-8 is linked to B-cell tumors, specifically primary effusion lymphoma and multicentric Castleman's disease, in addition to endothelial-derived KS. HHV-8 is unusual in its possession of a plethora of "accessory" genes and encoded proteins in addition to the core, conserved herpesvirus and gammaherpesvirus genes that are necessary for basic biological functions of these viruses. The HHV-8 accessory proteins specify not only activities deducible from their cellular protein homologies but also novel, unsuspected activities that have revealed new mechanisms of virus-host interaction that serve virus replication or latency and may contribute to the development and progression of virus-associated neoplasia. These proteins include viral interleukin-6 (vIL-6), viral chemokines (vCCLs), viral G protein-coupled receptor (vGPCR), viral interferon regulatory factors (vIRFs), and viral antiapoptotic proteins homologous to FLICE (FADD-like IL-1β converting enzyme)-inhibitory protein (FLIP) and survivin. Other HHV-8 proteins, such as signaling membrane receptors encoded by open reading frames K1 and K15, also interact with host mechanisms in unique ways and have been implicated in viral pathogenesis. Additionally, a set of micro-RNAs encoded by HHV-8 appear to modulate expression of multiple host proteins to provide conditions conducive to virus persistence within the host and could also contribute to HHV-8-induced neoplasia. Here, we review the molecular biology underlying these novel virus-host interactions and their potential roles in both virus biology and virus-associated disease.
  • Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer.Recent Results Cancer Res.2014;193:227-68. doi: 10.1007/978-3-642-38965-8_13.
  • Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the second identified human gammaherpesvirus. Like its relative Epstein-Barr virus, HHV-8 is linked to B-cell tumors, specifically primary effusion lymphoma and multicentric Castleman's disease, in addition
  • PMID 24008302
  • Brain localization of Kaposi's sarcoma in a patient treated by combination antiretroviral therapy.
  • Baldini F, Baiocchini A, Schininà V, Agrati C, Giancola ML, Alba L, Grisetti S, Del Nonno F, Capobianchi MR, Antinori A.AbstractBACKGROUND: Central nervous system is a very rare site of Kaposi's sarcoma in acquired immunodeficiency syndrome. Kaposi's sarcoma, a neoplasm of endothelial origin, occurs mainly in the skin, but can involve many tissues, especially in patients with a poor immunity. Combination antiretroviral therapy, highly active against human immunodeficiency virus type-1, has caused a dramatic reduction of cutaneous and visceral involvements. No report of central nervous system localization of Kaposi's sarcoma is described since the introduction of combination antiretroviral therapy in the late 90's.
  • BMC infectious diseases.BMC Infect Dis.2013 Dec 21;13(1):600. [Epub ahead of print]
  • BACKGROUND: Central nervous system is a very rare site of Kaposi's sarcoma in acquired immunodeficiency syndrome. Kaposi's sarcoma, a neoplasm of endothelial origin, occurs mainly in the skin, but can involve many tissues, especially in patients with a poor immunity. Combination antiretroviral thera
  • PMID 24359263
  • A man with oral lesions, constipation and back pain.
  • Mu A, Nassar N.Author information Division of Infectious Diseases, University of California San Francisco, Fresno Medical Education Program, Fresno, USA.AbstractAn unusual presentation of disseminated Kaposi sarcoma in a 49-year old African-American male with AIDS who was admitted to the hospital for constipation and back pain. Magnetic resonance imaging of the thoracic and lumbar spine were grossly abnormal, however, a biopsy of the iliac crest was interpreted as normal. The patient remained a diagnostic enigma until disseminated Kaposi sarcoma was suspected, based on vascular plaque-like lesions observed on his hard palate and right conjunctiva. Slides of the bone biopsy with were stained for human herpes virus-8 (HHV-8) antigen, and were positive. AIDS-related skeletal manifestations of Kaposi sarcoma have been reported in the literature but are infrequent.
  • International journal of STD & AIDS.Int J STD AIDS.2013 Dec 18. [Epub ahead of print]
  • An unusual presentation of disseminated Kaposi sarcoma in a 49-year old African-American male with AIDS who was admitted to the hospital for constipation and back pain. Magnetic resonance imaging of the thoracic and lumbar spine were grossly abnormal, however, a biopsy of the iliac crest was interpr
  • PMID 24352119

和文文献

  • 臨床例 低用量エトポシド療法で長期間完全寛解を維持した原発性滲出液リンパ腫
  • 和田 祥枝,北詰 浩一,濱川 真治 [他]
  • 診断と治療 100(9), 1581-1584, 2012-09
  • NAID 40019433168
  • 特殊な疾患に伴う肺高血圧症 : ウイルス感染に関連する肺高血圧発症メカニズム (第1土曜特集 肺高血圧症診療の進歩) -- (肺高血圧症各論(疾患の解説と内科治療))

関連リンク

2010年12月28日 ... 片野晴隆:HHV-8の感染病理学的研究:ウィルス, 2003:pdf。HHV-8は、感染者唾液 中に多くのウィルスが検出される事から、唾液を介した粘膜感染が推測されている。 ウィルス受容体はインテグリンα3β1で、B細胞や血管内皮細胞などの ...

関連画像

 herpesvirus 8 hhv 8 in saliva 1200x800Al HHV-8, descubierto por primera vez en HHV-8.jpginfezione da HHV-8 è stata associata Kaposi Sarcoma-Associated HerpesvirusCase 160 - Discussion


★リンクテーブル★
先読みKaposi sarcoma-associated herpesvirus」「Kaposi's sarcoma-associated herpesvirus
リンク元ヘルペスウイルス科」「ヒトヘルペスウイルス」「カポジ肉腫」「カポジ肉腫関連ウイルス」「KSHV
関連記事H」「HH」「HHV

Kaposi sarcoma-associated herpesvirus」

  [★]

KS,KSHV
herpesvirus, type 8


Kaposi's sarcoma-associated herpesvirus」

  [★] カポジ肉腫関連ヘルペスウイルス

ヘルペスウイルス科」

  [★]

Herpesviridae
疱疹ウイルス
ヘルペスウイルス亜科ウイルス

ヘルペス科に属するウイルスによる感染症 (SMB.526)

ヘルペスウイルス亜科
ヘルペスウイルス亜科
ヘルペスウイルス亜科
ヘルペスウイルス 潜伏部位 初感染における
顕性感染率
主な疾患
α 単純ヘルペスウイルス1型 HSV-1 知覚神経節 口唇ヘルペス口内炎角膜ヘルペスヘルペス脳炎性器ヘルペス新生児ヘルペス
単純ヘルペスウイルス2型 HSV-2 性器ヘルペス新生児ヘルペス、ヘルペス?疽、殿部ヘルペス
水痘・帯状疱疹ウイルス VZV 水痘帯状疱疹ラムゼイ・ハント症候群
β サイトメガロウイルス CMV 顆粒球/マクロファージ前駆細胞 先天性巨細胞封入体症、輸血後CMV単球症、臓器移植後間質性肺炎肝炎
ヒトヘルペスウイルス6型 HHV-6 マクロファージ 突発性発疹脳炎
ヒトヘルペスウイルス7型 HHV-7 唾液腺? 突発性発疹
γ エプスタイン-バーウイルス EBV 骨髄Bリンパ球 伝染性単核症バーキットリンパ腫上咽頭癌日和見リンパ腫
ヒトヘルペスウイルス8型 HHV-8 Bリンパ球 カポジ肉腫キャッスルマン病



ヒトヘルペスウイルス」

  [★]

human herpes virus, HHV
ウイルス



カポジ肉腫」

  [★]

Kaposi sarcoma, Kaposi's sarcoma
sarcoma Kaposi
特発性多発性色素性肉腫 idiopathic multiple pigmented sarcoma特発性多発性出血性肉腫 idiopathic multiple hemorrhagic sarcoma
AIDS日和見感染症


概念

  • 1995年
  • Human herpesvirus-8 HHV-8が原因
  • 免疫低下(HIV感染症により発症する)

病原体

  • HHV-8

症状

[show details]

国試


カポジ肉腫関連ウイルス」

  [★]

kaposi sarcoma-associated virus, KSHV
カポジ肉腫関連ヘルペスウイルス kaposi sarcoma-associated herpes virus Kaposi's sarcoma-associated herpes virusヒトヘルペスウイルス8ヒトヘルペスウイルス8型 HHV-8 HHV8 Herpesvirus 8, Human human herpes virus type 8、human herpesvirus 8
ラジノウイルスカポジ肉腫

KSHV」

  [★] カポジ肉腫関連ヘルペスウイルス, Kaposi sarcoma-associated herpesvirus, Kaposi's sarcoma-associated herpesvirus

HHV-8human herpesvirus 8, Kaposi sarcoma herpesvirus


H」

  [★]

WordNet   license wordnet

「the 8th letter of the Roman alphabet」
h

PrepTutorEJDIC   license prepejdic

「hydrogenの化学記号」

PrepTutorEJDIC   license prepejdic

「鉛筆の硬度 / 《俗》heroin」


HH」

  [★]

HHV」

  [★] ヒトヘルペスウイルス


"http://meddic.jp/HHV-8" より作成


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