H-Y抗原
WordNet
- the 8th letter of the Roman alphabet (同)h
- any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
- the 25th letter of the Roman alphabet (同)y, wye
PrepTutorEJDIC
- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
- 抗原(生物の体内にはいって免疫体を作る物質)
- yttriumの化学記号
- y-axis
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/03/04 15:51:32」(JST)
[Wiki en表示]
H-Y antigen is a male tissue specific antigen.[1] Originally thought to trigger the formation of testes, it is now known that it doesn't trigger the formation of testes but may be activated by the formation of testes.[2] In its production, there are at least two loci involved, an autosomal gene that generates the antigen and one that generates the receptor.[3]
The H-Y antigen secreted by the testis is identical to müllerian-inhibiting substance.[1]
Association with spermatogenesis
It has been shown that male mice lacking in the H-Y antigen, hence lacking in the gene producing it, have also lost genetic information responsible for spermatogenesis.[4] This result also identified a gene on the mouse Y chromosome, distinct from the testis-determining gene, that was essential for spermatogenesis, thus raising the possibility that the very product of this "spermatogenesis gene" is the H-Y antigen.[4]
Male homosexuality and the birth order effect
Among humans, it has been observed that men with more older brothers tend to have a higher chance of being homosexual - in fact, for every additional older brother, a man's chance of being homosexual can rise by up to 33%.[5] One theory to explain this involves H-Y antigens, which suggests that a maternal immune reaction to these antigens has, to an extent, an inhibitory effect on the masculinization of the brain, and therefore, the more male foetuses that the mother of a man has had, the greater the maternal immune response towards him[6] and thus the greater the inhibitory effect on brain masculinization, which is believed to be a factor in sexual orientation.[5] This hypothesis is supported by evidence that older sisters have no discernible influence on the sexual orientation of later-born males, which would be expected since H-Y antigen is male tissue specific, the 'probable involvement of H-Y antigen in the development of sex-typical traits, and the detrimental effects of immunization of female mice to H-Y antigen on the reproductive performance of subsequent male offspring'.[7]
References
- ^ a b Müller U, H-Y antigens - Hum Genet. 1996 Jun;97(6):701-4.
- ^ Wolf U, The serologically detected H-Y antigen revisited - Cytogenet Cell Genet. 1998;80(1-4):232-5.
- ^ H-Y Antigen -- Medical Definition
- ^ a b Burgoyne P S, Levy E R, McLaren A Spermatogenic failure in male mice lacking H-Y antigen - Nature. 1986 Mar 13-19;320(6058):170-2.
- ^ a b Ridley, M. 2000. Genome: The Autobiography of a Species in 23 Chapters. Harper and Collins.
- ^ Vaccination and immunity for iGCSE Biology - YouTube
- ^ Blanchard R, Klassen P H-Y antigen and homosexuality in men - J Theor Biol. 1997 Apr 7;185(3):373-8.
UpToDate Contents
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English Journal
- Young Female Donors Do Not Increase Risk of GVHD or Impact Overall Outcomes in Pediatric HLA-Matched Sibling HSCT.
- Friedrich P1, Guerra-Garcia P2, Stetson A3, Duncan C3, Lehmann L4.
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2017 Sep 25. pii: S1083-8791(17)30725-5. doi: 10.1016/j.bbmt.2017.09.014. [Epub ahead of print]
- PMID 28958895
- Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches.
- Gallardo D1, Bosch-Vizcaya A2, Rodríguez-Romanos R2, Santos N2, Buño I3, de la Cámara R4, Brunet S5, Jiménez-Velasco A6, González M7, Nieto JB8, Martínez-Laperche C3, Vallejo C9, Ferrá C10, Sampol A11, López-Jiménez J12, Pérez-Simón JA13, Martínez C14, Díez JL3; GvHD/Immunotherapy Committee of the Spanish Hematopoietic Transplant Group.
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2017 Aug 4. pii: S1083-8791(17)30618-3. doi: 10.1016/j.bbmt.2017.08.003. [Epub ahead of print]
- PMID 28827064
- Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).
- Xi R1, Pun IH1, Menezes SV1, Fouani L1, Kalinowski DS1, Huang ML1, Zhang X1, Richardson DR2, Kovacevic Z2.
- Molecular pharmacology.Mol Pharmacol.2017 May;91(5):499-517. doi: 10.1124/mol.116.107870. Epub 2017 Mar 8.
- PMID 28275050
Japanese Journal
- Sexing murine embryos with an indirect immunofluorescence assay using phage antibody B9-Fab against SDM antigen
- Sexing murine embryos with an indirect immunofluorescence assay using phage antibody B9-Fab against SDM antigen
- 抗原放出装置(ARD)の血清および乳中ラクトフェリン濃度に対する影響(臨床病理学)
- The journal of veterinary medical science 70(8), 819-824, 2008-08-25
- NAID 110006878930
Related Links
- antigen /an·ti·gen/ (an´tĭ-jen) any substance capable of inducing a specific immune response and of reacting with the products of that response, i.e., with specific antibody or specifically sensitized T lymphocytes, or both. Abbreviated ...
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