WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

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α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.

Yin G1, Lopes da Fonseca T2, Eisbach SE2, Anduaga AM3, Breda C3, Orcellet ML4, Szegő EM2, Guerreiro P2, Lazaro D2, Braus GH5, Fernandez CO4, Griesinger C1, Becker S1, Goody RS6, Itzen A7, Giorgini F3, Outeiro TF8, Zweckstetter M9.
Neurobiology of disease.Neurobiol Dis.2014 Jun 28. pii: S0969-9961(14)00182-X. doi: 10.1016/j.nbd.2014.06.018. [Epub ahead of print]
Alpha-Synuclein (αS) misfolding is associated with Parkinson's disease (PD) but little is known about the mechanisms underlying αS toxicity. Increasing evidence suggests that defects in membrane transport play an important role in neuronal dysfunction. Here we demonstrate that the GTPase Rab8a int
PMID 24983211

Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

Miotto MC1, Rodriguez EE, Valiente-Gabioud AA, Torres-Monserrat V, Binolfi A, Quintanar L, Zweckstetter M, Griesinger C, Fernández CO.
Inorganic chemistry.Inorg Chem.2014 May 5;53(9):4350-8. doi: 10.1021/ic4031377. Epub 2014 Apr 11.
Amyloid aggregation of α-synuclein (AS) has been linked to the pathological effects associated with Parkinson's disease (PD). Cu(II) binds specifically at the N-terminus of AS and triggers its aggregation. Site-specific Cu(I)-catalyzed oxidation of AS has been proposed as a plausible mechanism for
PMID 24725094

The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.

Levin J1, Schmidt F, Boehm C, Prix C, Bötzel K, Ryazanov S, Leonov A, Griesinger C, Giese A.
Acta neuropathologica.Acta Neuropathol.2014 May;127(5):779-80. doi: 10.1007/s00401-014-1265-3. Epub 2014 Mar 11.
PMID 24615514