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a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"

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(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/27 11:12:03」(JST)

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Gradenigo's syndrome, also called Gradenigo-Lannois syndrome^[1]^[2] and petrous apicitis, is a complication of otitis media and mastoiditis involving the apex of the petrous temporal bone. It was first described by Giuseppe Gradenigo in 1904 when he reported a triad of symptoms consisting of periorbital unilateral pain related to trigeminal nerve involvement, diplopia due to sixth nerve palsy and persistent otorrhea, associated with bacterial otitis media with apex involvement of the petrous part of the temporal bone (petrositis). The classical syndrome related to otitis media has become very rare after the antibiotic era.

Symptoms[edit]

Other symptoms of the syndrome include:

retroorbital pain due to pain in the area supplied by the ophthalmic branch of the trigeminal nerve (fifth cranial nerve),
Bell's palsy caused by involvement of the facial nerve (seventh cranial nerve), and
otitis media.

Other symptoms can include photophobia, excessive lacrimation, fever, and reduced corneal sensitivity.
The syndrome is usually caused by the spread of an infection into the petrous apex of the temporal bone.

Eponym[edit]

It is named after Count Giuseppe Gradenigo, an Italian Otolaryngologist, and Maurice Lannois.^[3]

References[edit]

^ Devic M, Boucher M, Raveau M (Apr 1966). "Some cases of Gradenigo-Lannois syndrome". Journal de médecine de Lyon 47 (96): 537–547. ISSN 0021-7883. PMID 4286558.
^ Bléry M, Chagnon S, Picard A, Babin C (Nov 1980). "Cranial osteitis: a report on four cases, including a Gradenigo-Lannois syndrome (author's transl)". Journal de radiologie 61 (11): 677–681. ISSN 0221-0363. PMID 7452536.
^ synd/738 at Who Named It?

UpToDate Contents

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1. 小児における急性乳様突起炎：臨床的特徴および診断 acute mastoiditis in children clinical features and diagnosis
2. 成人における急性中耳炎（化膿性および漿液性） acute otitis media in adults suppurative and serous
3. 敗血症性硬膜静脈洞血栓症 septic dural sinus thrombosis
4. 小児における耳漏（耳だれ）の評価 evaluation of otorrhea ear discharge in children

English Journal

Teaching NeuroImages: Gradenigo syndrome.

Delgado ME, Del Brutto OH.SourceFrom the Intensive Care Unit (M.E.D.), Hospital de Infectología José Daniel Rodríguez Maridueña, Ministerio de Salud Pública; and Department of Neurological Sciences (O.H.D.B.), Hospital-Clínica Kennedy, Guayaquil, Ecuador.
Neurology.Neurology.2012 Oct 16;79(16):e141. doi: 10.1212/WNL.0b013e31826e9b89.
PMID 23071172

Comparison between needle-knife fistulotomy and standard cannulation in ERCP.

Ayoubi M, Sansoè G, Leone N, Castellino F.SourceMohammad Ayoubi, Gianni Sansoè, Nicola Leone, Francesca Castellino, Endoscopy unit, Gradenigo Hospital, 10153 Torino, Italy.
World journal of gastrointestinal endoscopy.World J Gastrointest Endosc.2012 Sep 16;4(9):398-404. doi: 10.4253/wjge.v4.i9.398.
AIM: To compare the rates of success and complications of two different methods of access into the common bile duct (CBD).METHODS: Between October 2007 and November 2008, 173 consecutive patients (71 men, 102 women, mean age 68.6 years) requiring endoscopic retrograde cannulation of the papilla and
PMID 23125897