WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 7th letter of the Roman alphabet (同)g

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蛋白(たんばく)質

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/19 23:35:02」(JST)

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guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Identifiers
Symbol	GNA15
Entrez	2769
HUGO	4383
OMIM	139314
RefSeq	NM_002068
UniProt	P30679
Other data
Locus	Chr. 19 p13.3

G_q protein (G_αq, or G_q/11) is a heterotrimeric G protein subunit that activates phospholipase C (PLC). PLC in turn hydrolyzes Phosphatidylinositol 4,5-bisphosphate (PIP₂) to diacyl glycerol (DAG) and inositol trisphosphate (IP₃) signal transduction pathway. DAG acts as a second messenger that activates Protein Kinase C (PKC) and IP₃ helps in phosphorylation of some proteins.

Function

G_q proteins are class of G proteins which work to activate phospholipase C (PLC), participating in a variety of cellular signaling pathways.^[1]

The G_q protein works by activating PLC. PLC then cleaves a phospholipid. In the process, phosphatidylinositol 4,5-bisphosphate (PIP2) is cleaved into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP₃). DAG remains bound to the membrane, and IP₃ is released as a soluble structure into the cytosol. IP₃ then diffuses through the cytosol to bind to IP₃ receptors, particular calcium channels in the endoplasmic reticulum (ER). These channels are specific to calcium and only allow the passage of calcium to move through. This causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.^[1]

Further reading: Calcium function in vertebrates

In addition, calcium and DAG together work to activate PKC, which goes on to phosphorylate other molecules, leading to altered cellular activity.^[1]

Further reading: function of protein kinase C

Examples of GPCR partners

From modulatory neurotransmitter receptors (amine receptors belonging to rhodopsin family), G_q has been shown to be pre-coupled with G_q-coupled receptors physically and is functionally coupled to e.g. the G-protein coupled receptors:^[2]

5-HT₂ serotonergic receptors
Alpha-1 adrenergic receptor
Vasopressin type 1 receptors: 1A and 1B
Angiotensin II receptor type 1
Calcitonin receptor
Histamine H1 receptor
Metabotropic glutamate receptor, Group I
M₁, M₃, and M₅ muscarinic receptors^[2]
Trace amine-associated receptor 1

It has been shown that Gq proteins are preassembled (pre-coupled) with Gq-coupled receptors (such as M₃ receptor. The common polybasic domain in the C-tail of Gq-coupled receptors is necessary for the receptor-G protein preassembly.^[2]

Genes

GNAQ, GNA11, GNA14, GNA15

References

^ ^a ^b ^c Alberts B, Lewis J, Raff M, Roberts K, Walter P (2002). Molecular biology of the cell (4th ed.). New York: Garland Science. ISBN 0-8153-3218-1.
^ ^a ^b ^c Kou Qin, Chunmin Dong, Guangyu Wu & Nevin A Lambert (August 2011). "Inactive-state preassembly of Gq-coupled receptors and Gq heterotrimers". Nature Chemical Biology 7 (11): 740–747. doi:10.1038/nchembio.642. PMC 3177959. PMID 21873996.

External links

Gq protein at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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English Journal

Astrocytic 5-HT2B Receptor as in vitro and in vivo Target of SSRIs.

Peng L, Huang J.SourceDepartment of Clinical Pharmacology, China Medical University, No. 92 Beier Road, Heping District, Shenyang, P.R. China. hkkid08@yahoo.com.
Recent patents on CNS drug discovery.Recent Pat CNS Drug Discov.2012 Dec 1;7(3):243-53.
Most studies in this journal describe recent patents. The present study only has one such reference. Instead, we hope that its contents will trigger investigation of antidepressant drugs along the suggested lines and lead to ensuing patent applications - first and foremost by more focus on astrocyte
PMID 22963281

HIV-1 Nef Impairs Heterotrimeric G-protein Signaling by Targeting Gαi2 for Degradation through Ubiquitination.

Chandrasekaran P, Buckley M, Moore V, Wang LQ, Kehrl JH, Venkatesan S.SourceFrom the Laboratory of Molecular Immunology and.
The Journal of biological chemistry.J Biol Chem.2012 Nov 30;287(49):41481-98. doi: 10.1074/jbc.M112.361782. Epub 2012 Oct 15.
The HIV Nef protein is an important pathogenic factor that modulates cell surface receptor trafficking and impairs cell motility, presumably by interfering at multiple steps with chemotactic receptor signaling. Here, we report that a dominant effect of Nef is to trigger AIP4 E3 ligase-mediated Gα(i
PMID 23071112

Japanese Journal

Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation

Nature Communications 8, 2017-11-10
NAID 120006365525

Drosophila melanogaster rhodopsin Rh7 is a UV-to-visible light sensor with an extraordinarily broad absorption spectrum

Scientific Reports 7, 2017-08-04
NAID 120006335639

Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells

British journal of pharmacology 173(6), 1018-1032, 2016-03
NAID 120005981358

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★リンクテーブル★

リンク元	「Gqタンパク質」「Gq-G11 GTP-binding protein alpha subunit」
関連記事	「Gq」「G」

「Gqタンパク質」

guanine nucleotide binding protein (G protein), alpha 14
Identifiers
Symbol	GNA14
Entrez	9630
HUGO	4382
OMIM	604397
RefSeq	NM_004297
UniProt	O95837
Other data
Locus	Chr. 9 q21

guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Identifiers
Symbol	GNA11
Entrez	2767
HUGO	4379
OMIM	139313
RefSeq	NM_002067
UniProt	P29992
Other data
Locus	Chr. 19 p13.3

guanine nucleotide binding protein (G protein), q polypeptide
Identifiers
Symbol	GNAQ
Entrez	2776
HUGO	4390
OMIM	600998
RefSeq	NM_002072
UniProt	P50148
Other data
Locus	Chr. 9 q21