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A β-integrin from sea cucumber Apostichopus japonicus exhibits LPS binding activity and negatively regulates coelomocyte apoptosis.

Wang Z1, Shao Y1, Li C2, Lv Z1, Wang H1, Zhang W1, Zhao X1.
Fish & shellfish immunology.Fish Shellfish Immunol.2016 May;52:103-10. doi: 10.1016/j.fsi.2016.03.031. Epub 2016 Mar 16.
Integrins are a family of membrane glycoproteins, which are the major receptors for extracellular matrix and cell-cell adhesion molecules. In this study, a 1038 bp sequence representing the full-length cDNA of a novel β-integrin subunit (designated as AjITGB) was cloned from Apostichopus japonicus
PMID 26994670

Proline 235 plays a key role in the regulation of the oligomeric states of Thermotoga maritima Arginine Binding Protein.

Smaldone G1, Vigorita M2, Ruggiero A3, Balasco N4, Dattelbaum JD5, D'Auria S6, Del Vecchio P7, Graziano G2, Vitagliano L8.
Biochimica et biophysica acta.Biochim Biophys Acta.2016 Apr 14. pii: S1570-9639(16)30075-9. doi: 10.1016/j.bbapap.2016.04.006. [Epub ahead of print]
The Arginine Binding Protein isolated from Thermotoga maritima (TmArgBP) is a protein endowed with several peculiar properties. We have previously shown that TmArgBP dimerization is a consequence of the swapping of the C-terminal helix. Here we explored the structural determinants of TmArgBP domain
PMID 27087545

The application of a novel, cell permeable activity-based probe for the detection of cysteine cathepsins.

Hughes CS1, Shaw G1, Burden RE1, Scott CJ1, Gilmore BF2.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Apr 8;472(3):444-50. doi: 10.1016/j.bbrc.2016.01.062. Epub 2016 Jan 12.
Cysteine cathepsins, such as cathepsin S (CTSS), are implicated in the pathology of a wide range of diseases and are of potential utility as diagnostic and prognostic biomarkers. In previous work, we demonstrated the potency and efficiency of a biotinylated diazomethylketone (DMK)-based activity-bas
PMID 26792724

Replacement of Tyr50 stacked on the si-face of the isoalloxazine ring of the flavin adenine dinucleotide prosthetic group modulates Bacillus subtilis ferredoxin-NADP+ oxidoreductase activity toward NADPH

Seo Daisuke,Naito Hiroshi,Nishimura Erika,Sakurai Takeshi
Photosynthesis Research 125(1-2), 321-328, 2015-02-20
… To investigate the role of the si-face Tyr50 residue in BsFNR, we replaced Tyr50 with Gly, Ser, and Trp and examined its spectroscopic properties and enzymatic activities in the presence of NADPH and ferredoxin (Fd) from B. … The replacement of Tyr50 to Gly (Y50G), Ser (Y50S), and Trp (Y50W) in BsFNR resulted in a blue shift of the FAD transition bands. …
NAID 120005602822

Identification of a 4-Deoxy-L-erythro-5-hexoseulose Uronic Acid Reductase, FlRed, in an Alginolytic Bacterium Flavobacterium sp Strain UMI-01

Inoue Akira,Nishiyama Ryuji,Mochizuki Shogo,Ojima Takao
Marine Drugs 13(1), 493-508, 2015-01
… Common sequence motifs of SDR-superfamily enzymes, e.g., the catalytic tetrad Asn-Lys-Tyr-Ser and the cofactor-binding sequence Thr-Gly-x-x-x-Gly-x-Gly in Rossmann fold, were completely conserved in FlRed. … On the other hand, an Arg residue that determined the NADPH-specificity of Sphingomonas A1-R was replaced by Glu in FlRed. …
NAID 120005593437

Recombinant gamma T305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'a' and calcium binding sites

Ikeda Minami,Kobayashi Tamaki,Arai Shinpei,Mukai Saki,Takezawa Yuka,Terasawa Fumiko,Okumura Nobuo
THROMBOSIS RESEARCH 134(2), 518-525, 2014-08
… We then functionally analyzed and compared with that of nearby recombinant γN308K fibrinogen.ResultsDNA sequence analysis revealed a heterozygous γT305A substitution (mature protein residue number). …
NAID 120005608309