GRK4

• Gタンパク質共役受容体キナーゼ4

関

G-protein-coupled receptor kinase 4

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/12 15:40:17」(JST)

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G protein-coupled receptor kinase 4
Identifiers
Symbols	GRK4 ; GPRK2L; GPRK4; GRK4a; IT11
External IDs	OMIM: 137026 MGI: 95801 HomoloGene: 23158 IUPHAR: 1468 ChEMBL: 5861 GeneCards: GRK4 Gene
EC number	2.7.11.16
Gene ontology Molecular function • G-protein coupled receptor kinase activity • ATP binding • rhodopsin kinase activity Cellular component • cytosol • cell cortex • dendrite • neuronal cell body Biological process • G-protein coupled receptor internalization • protein phosphorylation • signal transduction • regulation of G-protein coupled receptor protein signaling pathway • receptor internalization • termination of G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2868	14772
Ensembl	ENSG00000125388	ENSMUSG00000052783
UniProt	P32298	O70291
RefSeq (mRNA)	NM_001004056	NM_001080743
RefSeq (protein)	NP_001004056	NP_001074212
Location (UCSC)	Chr 4: 2.97 – 3.04 Mb	Chr 5: 34.66 – 34.76 Mb
PubMed search	[1]	[2]

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.

References

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Sallese M, Lombardi MS, De Blasi A (1994). "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning". Biochem. Biophys. Res. Commun. 199 (2): 848–54. doi:10.1006/bbrc.1994.1306. PMID 8135832. 
• Premont RT, Macrae AD, Stoffel RH et al. (1996). "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants". J. Biol. Chem. 271 (11): 6403–10. doi:10.1074/jbc.271.11.6403. PMID 8626439.  CS1 maint: Explicit use of et al. (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Sallese M, Mariggiò S, Collodel G et al. (1997). "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells". J. Biol. Chem. 272 (15): 10188–95. doi:10.1074/jbc.272.15.10188. PMID 9092566.  CS1 maint: Explicit use of et al. (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  CS1 maint: Explicit use of et al. (link)
• Lazari MF, Liu X, Nakamura K et al. (1999). "Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor". Mol. Endocrinol. 13 (6): 866–78. doi:10.1210/me.13.6.866. PMID 10379886.  CS1 maint: Explicit use of et al. (link)
• Blaukat A, Pizard A, Breit A et al. (2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function". J. Biol. Chem. 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230.  CS1 maint: Explicit use of et al. (link)
• Watanabe H, Xu J, Bengra C et al. (2003). "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4". Kidney Int. 62 (3): 790–8. doi:10.1046/j.1523-1755.2002.00525.x. PMID 12164861.  CS1 maint: Explicit use of et al. (link)
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  CS1 maint: Explicit use of et al. (link)
• Perroy J, Adam L, Qanbar R et al. (2003). "Phosphorylation-independent desensitization of GABAB receptor by GRK4". EMBO J. 22 (15): 3816–24. doi:10.1093/emboj/cdg383. PMC 169056. PMID 12881416.  CS1 maint: Explicit use of et al. (link)
• Speirs HJ, Katyk K, Kumar NN et al. (2004). "Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension". J. Hypertens. 22 (5): 931–6. doi:10.1097/00004872-200405000-00014. PMID 15097232.  CS1 maint: Explicit use of et al. (link)
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  CS1 maint: Explicit use of et al. (link)
• Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  CS1 maint: Explicit use of et al. (link)
• Rankin ML, Marinec PS, Cabrera DM et al. (2006). "The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4". Mol. Pharmacol. 69 (3): 759–69. doi:10.1124/mol.105.019901. PMID 16338988.  CS1 maint: Explicit use of et al. (link)
• Zhu H, Lu Y, Wang X et al. (2006). "The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins". Am. J. Hypertens. 19 (1): 61–6. doi:10.1016/j.amjhyper.2005.07.007. PMID 16461192.  CS1 maint: Explicit use of et al. (link)
• Zhu H, Lu Y, Wang X et al. (2006). "The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents". Pediatr. Res. 60 (4): 440–2. doi:10.1203/01.pdr.0000238250.64591.44. PMID 16940246.  CS1 maint: Explicit use of et al. (link)
• Wang Y, Li B, Zhao W et al. (2006). "Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese". Ann. Hum. Genet. 70 (Pt 6): 778–83. doi:10.1111/j.1469-1809.2006.00278.x. PMID 17044852.  CS1 maint: Explicit use of et al. (link)
• Wang Z, Armando I, Asico LD et al. (2007). "The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production". Am. J. Physiol. Heart Circ. Physiol. 292 (5): H2083–92. doi:10.1152/ajpheart.00944.2006. PMID 17259440.  CS1 maint: Explicit use of et al. (link)

UpToDate Contents

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English Journal

• α1 -Adrenoceptor activation of PKC-ε causes heterologous desensitization of thromboxane receptors in the aorta of spontaneously hypertensive rats.

• Zhao Y1, Vanhoutte PM1, Leung SW1.
• British journal of pharmacology.Br J Pharmacol.2015 Jul;172(14):3687-701. doi: 10.1111/bph.13157. Epub 2015 May 15.
• BACKGROUND AND PURPOSE: In the aorta of adult spontaneously hypertensive (SHR), but not in that of normotensive Wistar-Kyoto (WKY), rats, previous exposure to phenylephrine inhibits subsequent contractions to PGE2 . The present experiments were designed to examine the mechanism(s) underlying this in
• PMID 25857252

• Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.

• Allen SJ1, Parthasarathy G2, Darke PL2, Diehl RE2, Ford RE2, Hall DL2, Johnson SA3, Reid JC2, Rickert KW2, Shipman JM2, Soisson SM2, Zuck P3, Munshi SK2, Lumb KJ2.
• The Journal of biological chemistry.J Biol Chem.2015 Jul 1. pii: jbc.M115.648907. [Epub ahead of print]
• G protein-coupled receptor (GPCR) kinases (GRKs) bind to and phosphorylate GPCRs, initiating the process of GPCR desensitization and internalization. GRK4 is implicated in the regulation of blood pressure, and three GRK4 polymorphisms (R65L, A142V and A486V) are associated with hypertension. Here we
• PMID 26134571

• G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).

• Li L1, Homan KT2, Vishnivetskiy SA1, Manglik A3, Tesmer JJ2, Gurevich VV1, Gurevich EV4.
• The Journal of biological chemistry.J Biol Chem.2015 Apr 24;290(17):10775-90. doi: 10.1074/jbc.M115.644773. Epub 2015 Mar 13.
• G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in homologous desensitization of GPCRs. It is widely assumed that most GRKs selectively phosphorylate only active GPCRs. Here, we show that although this seems to be the case for the GRK2/3 subfamily, GRK5/6 effectively phosphorylate i
• PMID 25770216

Japanese Journal

• 食塩感受性高血圧の遺伝子指標としてのG蛋白質共役型受容体キナーゼ4(GRK4)遺伝子多型の意義 (プロジェクト研究(医学:2年度) 心・血管系における食塩感受性を規定する因子の解明)

• 眞田 寛啓,緑川 早苗,米田 実 [他]
• 財団法人ソルト・サイエンス研究財団助成研究報告集 2005年度, 21-27, 2005-00-00
• NAID 40015430631

• 食塩感受性高血圧の遺伝子指標としてのG蛋白質共役型受容体キナーゼ4(GRK4γ)遺伝子多型の意義 (プロジェクト研究(医学:初年度)心・血管系における食塩感受性を規定する因子の解明)

• 眞田 寛啓,緑川 早苗,米田 実 [他]
• 財団法人ソルト・サイエンス研究財団助成研究報告集 2004年度, 85-94, 2004-00-00
• NAID 40007480489

• ヒト過活動膀胱におけるムスカリンレセプター(M1,M2,M3)およびG蛋白質共役型受容体リン酸化酵素(GRK2,GRK3,GRK4)の発現量の変化

• 古谷 泰久,神家満 学,座光寺 秀典,滝花 義男,荒木 勇雄,田邉 信明,武田 正之
• 日本泌尿器科學會雜誌 94(2), 396, 2003-02-15
• NAID 110003072605

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★リンクテーブル★

リンク元	「G-protein-coupled receptor kinase 4」「Gタンパク質共役受容体キナーゼ4」
関連記事	「GRK」「GR」

「G-protein-coupled receptor kinase 4」

　　[★]

Gタンパク質共役受容体キナーゼ4

関

GRK4

「Gタンパク質共役受容体キナーゼ4」

　　[★]

英

G-protein-coupled receptor kinase 4、GRK4

「GRK」

　　[★]

Gタンパク質共役受容体キナーゼ

関

G-protein-coupled receptor kinase

関

G protein receptor kinase

「GR」

　　[★]

• グルココルチコイド受容体

関

glucocorticoid receptor