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the 7th letter of the Roman alphabet (同)g

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/25 13:03:03」(JST)

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GM2 is a type of ganglioside. G refers to ganglioside, the M is for monosialic (as in it has one sialic acid), and 2 refers to the fact that it was the second monosialic ganglioside discovered. It is associated with GM2 gangliosidoses such as Tay-Sachs disease.^[1]

Additional images

Sphingolipidoses
Structures of GM1, GM2, GM3 gangliosides

References

^ Guetta E, Peleg L (2008). "Rapid Detection of Fetal Mendalian Disorders: Tay-Sachs Disease". Methods Mol. Biol. 444: 147–59. doi:10.1007/978-1-59745-066-9_11. PMID 18425478.

External links

Ganglioside GM2 at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 進行黒色腫に対するインターロイキン2および実験的免疫学的アプローチ interleukin 2 and experimental immunotherapy approaches for advanced melanoma
2. 成人の免疫正常宿主におけるサイトメガロウイルス感染の疫学、臨床症状、および治療 epidemiology clinical manifestations and treatment of cytomegalovirus infection in immunocompetent adults
3. アシュケナージ系ユダヤ人集団における遺伝的疾患の保因者スクリーニング carrier screening for genetic disease in the ashkenazi jewish population
4. 小細胞肺癌の治療に対する実験的アプローチ experimental approaches to treatment for small cell lung cancer
5. 筋萎縮性側索硬化症の疫学および病因 epidemiology and pathogenesis of amyotrophic lateral sclerosis

English Journal

Acceleration of α-Synuclein Aggregation by Exosomes.

Grey M1, Dunning CJ2, Gaspar R3, Grey C4, Brundin P5, Sparr E6, Linse S7.
The Journal of biological chemistry.J Biol Chem.2015 Jan 30;290(5):2969-82. doi: 10.1074/jbc.M114.585703. Epub 2014 Nov 25.
Exosomes are small vesicles released from cells into extracellular space. We have isolated exosomes from neuroblastoma cells and investigated their influence on the aggregation of α-synuclein, a protein associated with Parkinson disease pathology. Using cryo-transmission electron microscopy of exos
PMID 25425650

Therapeutic activity of glycoengineered anti-GM2 antibodies against malignant pleural mesothelioma.

Li Q1, Wang W, Machino Y, Yamada T, Kita K, Oshima M, Sekido Y, Tsuchiya M, Suzuki Y, Nan-Ya K, Iida S, Nakamura K, Iwakiri S, Itoi K, Yano S.
Cancer science.Cancer Sci.2015 Jan;106(1):102-7. doi: 10.1111/cas.12575. Epub 2014 Dec 18.
Malignant pleural mesothelioma (MPM) is a rare and highly aggressive neoplasm that arises from the pleural, pericardial, or peritoneal lining. Although surgery, chemotherapy, radiotherapy, and combinations of these therapies are used to treat MPM, the median survival of such patients is dismal. Ther
PMID 25421609

Biomarkers for disease progression and AAV therapeutic efficacy in feline Sandhoff disease.

Bradbury AM1, Gray-Edwards HL2, Shirley JL2, McCurdy VJ1, Colaco AN3, Randle AN2, Christopherson PW4, Bird AC4, Johnson AK5, Wilson DU5, Hudson JA5, De Pompa NL5, Sorjonen DC5, Brunson BL6, Jeyakumar M3, Platt FM3, Baker HJ2, Cox NR7, Sena-Esteves M8, Martin DR9.
Experimental neurology.Exp Neurol.2015 Jan;263:102-12. doi: 10.1016/j.expneurol.2014.09.020. Epub 2014 Oct 5.
The GM2 gangliosidoses, Tay-Sachs disease (TSD) and Sandhoff disease (SD), are progressive neurodegenerative disorders that are caused by a mutation in the enzyme β-N-acetylhexosaminidase (Hex). Due to the recent emergence of novel experimental treatments, biomarker development has become particula
PMID 25284324

Japanese Journal

糖脂質による増殖シグナル向上のメカニズムの解明

川島永子
Cosmetology : Annual report of cosmetology 20, 122-127, 2012-00-00
NAID 40019435459

My journey into the world of sphingolipids and sphingolipidoses

SANDHOFF Konrad
Proceedings of the Japan Academy, Series B 88(10), 554-582, 2012
… Analysis of lipid storage in postmortem brains of patients with amaurotic idiocy led to the recognition of five lysosomal ganglioside storage diseases and identification of their inherited metabolic blocks. … Biosynthesis and intracellular trafficking of lysosomal hydrolases (hexosaminidases, acid sphingomyelinase and ceramidase) and lipid binding and transfer proteins (GM2 activator, saposins) were analyzed to identify the molecular and metabolic basis of several sphingolipidoses. …
NAID 130002540350

Simultaneous Development of Acute Disseminated Encephalomyelitis and Guillain-Barré Syndrome Associated with H1N1 09 Influenza Vaccination

Hoshino Takao,Uchiyama Yumiko,Ito Eiichi,Osawa Shunsuke,Ohashi Takashi
Internal Medicine 51(12), 1595-1598, 2012
… Furthermore, nerve conduction study showed acute sensorimotor neuropathy, and anti-GM2 antibodies were detected in his serum. … To our knowledge, this is the first case of co-morbid ADEM and GBS after influenza vaccination with positive anti-ganglioside antibodies. …
NAID 130002062164

Related Pictures

★リンクテーブル★

「G」

GM2
Names
	IUPAC name (2S,3R,4E)-3-Hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 2-acetamido-2-deoxy-β-D-galactopyranosyl-(1→4)-[5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranonosyl-(2→3)]-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside
	Other names Ganglioside GM2; Tay-Sachs ganglioside;; β-D-GalNAc-(1→4)-[α-Neu5Ac-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-N-octadecanoylsphingosine
Identifiers
CAS Registry Number	19600-01-2
ChEBI	CHEBI:60327
ChemSpider	26286730
	InChI InChI=1S/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1 ; Key: USMMPBVNWHAJBE-YMEOXFOQSA-N ; InChI=1/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1; Key: USMMPBVNWHAJBE-YMEOXFOQBT ;
Jmol-3D images	Image
	SMILES CCCCCCCCCCCCCCCCCC(=O)N[C@H](CO[C@H]1[C@H]([C@@H]([C@H]([C@@H](O1)CO)O[C@@H]2[C@H]([C@@H]([C@@H]([C@@H](O2)CO)O[C@@H]3[C@H]([C@@H]([C@@H]([C@@H](O3)CO)O)O)NC(=O)C)OC[C@]4(C[C@H]([C@@H]([C@H](O4)[C@H]([C@H](CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)[C@H](/C=C/CCCCCCCCCCCCC)O ;
Properties
Molecular formula	C67H121N3O26
Molar mass	1,384.68 g·mol−1
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references

　　[★]

[pmid18425478-1] Guetta E, Peleg L (2008). "Rapid Detection of Fetal Mendalian Disorders: Tay-Sachs Disease". Methods Mol. Biol. 444: 147–59. doi:10.1007/978-1-59745-066-9_11. PMID 18425478.

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案内

案内

GM2 ganglioside