GDNF receptor

• グリア細胞由来神経栄養因子受容体、グリア細胞由来神経栄養因子レセプター、GDNF受容体、GDNFレセプター

関

glial cell line-derived neurotrophic factor receptor

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/07/28 21:21:14」(JST)

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GFRA1
Identifiers
Aliases	GFRA1, GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1, GDNF family receptor alpha 1
External IDs	MGI: 1100842 HomoloGene: 3855 GeneCards: GFRA1
Gene location (Human) Chr. Chromosome 10 (human) Band 10q25.3 Start 116,056,925 bp End 116,273,467 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 D2|19 54.18 cM Start 58,235,604 bp End 58,455,909 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor activity • receptor binding • glial cell-derived neurotrophic factor receptor activity • Ras guanyl-nucleotide exchange factor activity • signaling receptor activity Cellular component • anchored component of membrane • extracellular exosome • membrane • extrinsic component of membrane • intracellular • plasma membrane • external side of plasma membrane • receptor complex Biological process • cell surface receptor signaling pathway • nervous system development • MAPK cascade • glial cell-derived neurotrophic factor receptor signaling pathway • axon guidance • regulation of molecular function Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2674	14585
Ensembl	ENSG00000151892	ENSMUSG00000025089
UniProt	P56159	P97785
RefSeq (mRNA)	NM_001145453 NM_005264 NM_145793 NM_001348096 NM_001348098 NM_001348099	NM_001285457 NM_010279
RefSeq (protein)	NP_001138925 NP_005255 NP_665736 NP_001335025 NP_001335027 NP_001335028	NP_001272386 NP_034409
Location (UCSC)	Chr 10: 116.06 – 116.27 Mb	Chr 19: 58.24 – 58.46 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene.

Function

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

GDNF family receptor alpha 1 has been shown to interact with GDNF and RET proto-oncogene.

See also

• GFRα

Further reading

• Treanor JJ, Goodman L, de Sauvage F, Stone DM, Poulsen KT, Beck CD, Gray C, Armanini MP, Pollock RA, Hefti F, Phillips HS, Goddard A, Moore MW, Buj-Bello A, Davies AM, Asai N, Takahashi M, Vandlen R, Henderson CE, Rosenthal A (Jul 1996). "Characterization of a multicomponent receptor for GDNF". Nature. 382 (6586): 80–3. doi:10.1038/382080a0. PMID 8657309.
• Jing S, Wen D, Yu Y, Holst PL, Luo Y, Fang M, Tamir R, Antonio L, Hu Z, Cupples R, Louis JC, Hu S, Altrock BW, Fox GM (Jun 1996). "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF". Cell. 85 (7): 1113–24. doi:10.1016/S0092-8674(00)81311-2. PMID 8674117.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Gattei V, Celetti A, Cerrato A, Degan M, De Iuliis A, Rossi FM, Chiappetta G, Consales C, Improta S, Zagonel V, Aldinucci D, Agosti V, Santoro M, Vecchio G, Pinto A, Grieco M (Apr 1997). "Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment". Blood. 89 (8): 2925–37. PMID 9108413.
• Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL (Jun 1997). "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6238–43. doi:10.1073/pnas.94.12.6238. PMC 21033. PMID 9177201.
• Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J (May 1997). "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret". Neuron. 18 (5): 793–802. doi:10.1016/S0896-6273(00)80318-9. PMID 9182803.
• Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A (Jun 1997). "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor". Nature. 387 (6634): 717–21. doi:10.1038/42722. PMID 9192898.
• Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
• Eng C, Myers SM, Kogon MD, Sanicola M, Hession C, Cate RL, Mulligan LM (Feb 1998). "Genomic structure and chromosomal localization of the human GDNFR-alpha gene". Oncogene. 16 (5): 597–601. doi:10.1038/sj.onc.1201573. PMID 9482105.
• Shefelbine SE, Khorana S, Schultz PN, Huang E, Thobe N, Hu ZJ, Fox GM, Jing S, Cote GJ, Gagel RF (Apr 1998). "Mutational analysis of the GDNF/RET-GDNFR alpha signaling complex in a kindred with vesicoureteral reflux". Human Genetics. 102 (4): 474–8. doi:10.1007/s004390050724. PMID 9600247.
• Cacalano G, Fariñas I, Wang LC, Hagler K, Forgie A, Moore M, Armanini M, Phillips H, Ryan AM, Reichardt LF, Hynes M, Davies A, Rosenthal A (Jul 1998). "GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney". Neuron. 21 (1): 53–62. doi:10.1016/S0896-6273(00)80514-0. PMC 2710137. PMID 9697851.
• Enokido Y, de Sauvage F, Hongo JA, Ninkina N, Rosenthal A, Buchman VL, Davies AM (Sep 1998). "GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin". Current Biology. 8 (18): 1019–22. doi:10.1016/S0960-9822(07)00422-8. PMID 9740802.
• Tansey MG, Baloh RH, Milbrandt J, Johnson EM (Mar 2000). "GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival". Neuron. 25 (3): 611–23. doi:10.1016/S0896-6273(00)81064-8. PMID 10774729.
• Hase A, Suzuki H, Arahata K, Akazawa C (Jul 1999). "Expression of human GFR alpha-1 (GDNF receptor) at the neuromuscular junction and myelinated nerves". Neuroscience Letters. 269 (1): 55–7. doi:10.1016/S0304-3940(99)00419-X. PMID 10821644.
• Cik M, Masure S, Lesage AS, Van Der Linden I, Van Gompel P, Pangalos MN, Gordon RD, Leysen JE (Sep 2000). "Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions". The Journal of Biological Chemistry. 275 (36): 27505–12. doi:10.1074/jbc.M000306200. PMID 10829012.
• Paratcha G, Ledda F, Baars L, Coulpier M, Besset V, Anders J, Scott R, Ibáñez CF (Jan 2001). "Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts". Neuron. 29 (1): 171–84. doi:10.1016/S0896-6273(01)00188-X. PMID 11182089.
• Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C (Apr 2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.
• Japón MA, Urbano AG, Sáez C, Segura DI, Cerro AL, Diéguez C, Alvarez CV (Apr 2002). "Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors". The Journal of Clinical Endocrinology and Metabolism. 87 (4): 1879–84. doi:10.1210/jc.87.4.1879. PMID 11932334.

UpToDate Contents

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• 1. 多発性内分泌腫瘍2型の分類および遺伝学classification and genetics of multiple endocrine neoplasia type 2 [show details]
  …of one of its four ligands, glial cell line-derived neurotrophic factor (GDNF), neurturin (TNT), artemin, or persephin, which require their specific co-receptors GDNF-receptor-family-a-1 (GFR-a-1), GFR-a-2 …
• 2. パーキンソン病への新たな疾患修飾療法potential disease modifying therapies for parkinson disease [show details]
  … Direct brain infusion of glial cell line derived neurotrophic factor (GDNF) appeared promising in a phase II open… is synthetic glucagon-like peptide-1 (GLP-1) receptor agonist that stimulates glucose-dependent insulin secretion,…
• 3. 甲状腺結節および非髄様甲状腺癌におけるオンコジーンおよび腫瘍抑制遺伝子oncogenes and tumor suppressor genes in thyroid nodules and nonmedullary thyroid cancer [show details]
  … RET/PTC and those resulting from NTRK1 rearrangements as TRK RET codes for a glial cell line-derived neurotrophic factor receptor with tyrosine kinase activity. Germline RET mutations cause the multiple endocrine …
• 4. 筋萎縮性側索硬化症への疾患修飾療法disease modifying treatment of amyotrophic lateral sclerosis [show details]
  … glial cell line-derived neurotrophic factor (GDNF) gene was injected into lower-extremity muscles… noncompetitive block of N-methyl-D-aspartate (NMDA) receptor mediated responses,…
• 5. 先天性巨大結腸症（ヒルシュスプルング病）congenital aganglionic megacolon hirschsprung disease [show details]
  … Mutations in both GDNF and neurturin have also been identified in patients with HD . The second major gene involved in HD is endothelin receptor B (EDNRB), which encodes a G-protein-coupled receptor . The proteins …

English Journal

• Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity.

• Wang YC1, Sanchez-Mendoza EH1, Doeppner TR1, Hermann DM1.
• Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.J Cereb Blood Flow Metab.2017 Mar;37(3):980-993. doi: 10.1177/0271678X16648971. Epub 2016 Jul 20.
• The NMDA antagonist memantine preferentially inhibits extrasynaptic NMDA receptors, which are overactivated upon stroke and thought to disturb neuroplasticity. We hypothesized that memantine enhances post-ischemic neurological recovery, brain remodeling, and plasticity. C57BL6/j mice were exposed to
• PMID 27170698

• Expression and localization of ARTEMIN in the bovine uterus and embryos.

• Gómez E1, Martin D1, Carrocera S1, Sánchez-Calabuig MJ2, Gutierrez-Adán A2, Alonso-Guervos M3, Peynot N4, Giraud-Delville C4, Sandra O4, Duranthon V4, Muñoz M5.
• Theriogenology.Theriogenology.2017 Mar 1;90:153-162. doi: 10.1016/j.theriogenology.2016.12.007. Epub 2016 Dec 6.
• Artemin a member of the glial cell line-derived neurotrophic factor (GDNF) family is present in mice and human preimplantation embryos, and reproductive tract, during early pregnancy promoting embryo development in vitro. The presence of artemin in cattle embryos and reproductive tract, however, is
• PMID 28166962

• A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease.

• Jalewa J1, Sharma MK1, Gengler S1, Hölscher C2.
• Neuropharmacology.Neuropharmacology.2017 Feb 20;117:238-248. doi: 10.1016/j.neuropharm.2017.02.013. [Epub ahead of print]
• The incretins glucagon-like peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are growth factors that have shown neuroprotective effects in animal models of Parkinson's and Alzheimer's disease. In addition, the GLP-1 mimetic exendin-4 has shown protective effects in a clinical
• PMID 28223210

Japanese Journal

• THE JOURNAL OF VITAMINOLOGY

• MIZUSHIGE Takafumi,NOGIMURA Dai,NAGAI Akitoshi,MITSUHASHI Haruka,TAGA Yuki,KUSUBATA Masashi,HATTORI Shunji,KABUYAMA Yukihito
• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 65(3), 251-257, 2019
• … The antidepressant activity of GDCH was abolished by pre-treatment with an antagonist of the dopamine receptor, but not treatment with a serotonin receptor antagonist. … GDCH significantly increased gene expression of glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) in the hippocampus, molecules that affect the differentiation and survival of neurons, relative to that in the control condition. …
• NAID 130007670177

• Expression dynamics of self-renewal factors for spermatogonial stem cells in the mouse testis

• SAKAI Mizuki,MASAKI Kaito,AIBA Shota,TONE Masaaki,TAKASHIMA Seiji
• 家畜繁殖学雑誌 64(3), 267-275, 2018
• … Glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are <i>bona fide</i> … Although GDNF is indispensable for the maintenance of SSCs, the role of FGF2 in the testis remains to be elucidated. … and <i>Gdnf</i> … It is well known that Sertoli cells express <i>Gdnf</i>, and its receptor is expressed in a subset of undifferentiated spermatogonia, including SSCs. …
• NAID 130007409986

• Expression dynamics of self-renewal factors for spermatogonial stem cells in the mouse testis

• SAKAI Mizuki,MASAKI Kaito,AIBA Shota,TONE Masaaki,TAKASHIMA Seiji
• 家畜繁殖研究會誌, 2018
• … <p>Glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are <i>bona fide</i> … Although GDNF is indispensable for the maintenance of SSCs, the role of FGF2 in the testis remains to be elucidated. … and <i>Gdnf</i> … It is well known that Sertoli cells express <i>Gdnf</i>, and its receptor is expressed in a subset of undifferentiated spermatogonia, including SSCs. …
• NAID 130006707989

Related Links

• GFRA1 GDNF family receptor alpha 1 [ (human)]

This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived ...

• GFRA1 - GDNF family receptor alpha-1 precursor - Homo ...

Isoform 1 (identifier: P56159-1) []FASTA Add to basket Added to basket This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the ...

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★リンクテーブル★

リンク元	「グリア細胞由来神経栄養因子受容体」「グリア細胞由来神経栄養因子レセプター」「GDNF受容体」「GDNFレセプター」「glial cell line-derived neurotrophic factor receptor」
関連記事	「GDNF」

「グリア細胞由来神経栄養因子受容体」

　　[★]

英

glial cell line-derived neurotrophic factor receptor、GDNF receptor

関

グリア細胞由来神経栄養因子レセプター、GDNF受容体、GDNFレセプター

「グリア細胞由来神経栄養因子レセプター」

　　[★]

英

glial cell line-derived neurotrophic factor receptor、GDNF receptor

関

グリア細胞由来神経栄養因子受容体、GDNF受容体、GDNFレセプター

「GDNF受容体」

　　[★]

英

GDNF receptor

関

グリア細胞由来神経栄養因子受容体、グリア細胞由来神経栄養因子レセプター、GDNFレセプター

「GDNFレセプター」

　　[★]

英

GDNF receptor

関

グリア細胞由来神経栄養因子受容体、グリア細胞由来神経栄養因子レセプター、GDNF受容体

「glial cell line-derived neurotrophic factor receptor」

　　[★]

• グリア細胞由来神経栄養因子受容体、グリア細胞由来神経栄養因子レセプター

関

GDNF receptor

「GDNF」

　　[★]

関

Glial-cell-derived neurotrophic factor