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the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated (同)gee, g-force
the 7th letter of the Roman alphabet (同)g

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carbonの化学記号
=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/21 21:48:45」(JST)

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The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene.^[1] G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).^[2] The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family.The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.

Isoforms

The class IV isoform defective for both internalization and differentiation signaling.

Clinical significance

Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.^[3]

Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.^[4]

In clinical medicine, there is a suggestion that use of GCSF should be avoided, at least in children and adolescents and perhaps adults, when G-CSFR isoform IV is overexpressed.^[5]

Interactions

Granulocyte colony-stimulating factor receptor has been shown to interact with Grb2,^[6] HCK^[7] and SHC1.^[6]

References

^ Tweardy D, Anderson K, Cannizzaro L, Steinman R, Croce C, Huebner K (March 1992). "Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34". Blood 79 (5): 1148–54. PMID 1371413.
^ "Entrez Gene: CSF3R colony stimulating factor 3 receptor (granulocyte)".
^ Zeidler C, Welte K (April 2002). "Kostmann syndrome and severe congenital neutropenia". Semin. Hematol. 39 (2): 82–8. doi:10.1053/shem.2002.31913. PMID 11957189.
^ Beekman R, Touw I (June 2010). "G-CSF and its receptor in myeloid malignancy". Blood 115 (25): 5131–6. doi:10.1182/blood-2010-01-234120. PMID 20237318.
^ Ehlers S, Herbst C, Zimmermann M, Scharn N, Germeshausen M, von Neuhoff N et al. (May 2010). "Granulocyte colony-stimulating factor (G-CSF) treatment of childhood acute myeloid leukemias that overexpress the differentiation-defective G-CSF receptor isoform IV is associated with a higher incidence of relapse". J. Clin. Oncol. 28 (15): 2591–7. doi:10.1200/JCO.2009.25.9010. PMID 20406937.
^ ^a ^b Ward A, Monkhouse J, Hamilton J, Csar X (November 1998). "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor". Biochim. Biophys. Acta 1448 (1): 70–6. doi:10.1016/S0167-4889(98)00120-7. PMID 9824671.
^ Ward A, Monkhouse J, Csar X, Touw I, Bello P (October 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochem. Biophys. Res. Commun. 251 (1): 117–23. doi:10.1006/bbrc.1998.9441. PMID 9790917.

External links

CSF3R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 慢性骨髄性白血病の臨床症状および診断 clinical manifestations and diagnosis of chronic myeloid leukemia
2. 先天性好中球減少症 congenital neutropenia
3. 急性骨髄性白血病の病因 pathogenesis of acute myeloid leukemia
4. 骨髄造血の制御 regulation of myelopoiesis
5. 遺伝性骨髄不全症候群における遺伝子組換え型造血成長因子 recombinant hematopoietic growth factors in inherited bone marrow failure syndromes

English Journal

FACS binding assay for analysing GDNF interactions.

Quintino L, Baudet A, Larsson J, Lundberg C.SourceCNS Gene Therapy, Department of Experimental Medical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
Journal of neuroscience methods.J Neurosci Methods.2013 Aug 15;218(1):25-8. doi: 10.1016/j.jneumeth.2013.04.006. Epub 2013 May 10.
Glial cell-line derived neurotrophic factor (GDNF) is a secreted protein with great therapeutic potential. However, in order to analyse the interactions between GDNF and its receptors, researchers have been mostly dependent of radioactive binding assays. We developed a FACS-based binding assay for G
PMID 23669067

Selective JAK/STAT3 signalling regulates transcription of colony stimulating factor-2 and -3 in Concanavalin-A-activated mesenchymal stromal cells.

Zgheib A, Pelletier-Bonnier E, Levros LC Jr, Annabi B.SourceLaboratoire d'Oncologie Moléculaire, Centre de recherche BIOMED, Département de Chimie, Université du Québec à Montréal, Québec, Canada.
Cytokine.Cytokine.2013 Aug;63(2):187-93. doi: 10.1016/j.cyto.2013.04.027. Epub 2013 May 17.
Human bone marrow-derived mesenchymal stromal cells (MSCs) express Toll-like receptors (TLRs) and produce cytokines and chemokines, all of which contribute to these cells' immunomodulatory and proangiogenic properties. Among the secreted cytokines, colony-stimulating factors (CSFs) regulate angiogen
PMID 23688618

Endothelin receptor antagonists attenuate the inflammatory response of human pulmonary vascular smooth muscle cells to bacterial endotoxin.

Knobloch J, Feldmann M, Wahl C, Jungck D, Behr J, Stoelben E, Koch A.SourceDepartment of Internal Medicine III for Pneumology, Allergology, Sleep and Respiratory Medicine, University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, D-44789, Bochum; Germany. andrea.koch@bergmannsheil.de.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2013 Aug;346(2):290-9. doi: 10.1124/jpet.112.202358. Epub 2013 May 29.
Bacterial infections induce exacerbations in chronic lung diseases, e.g., chronic obstructive pulmonary disease (COPD), by enhancing airway inflammation. Exacerbations are frequently associated with right heart decompensation and accelerate disease progression. Endothelin receptor antagonists (ERAs)
PMID 23720457

Japanese Journal

造血幹細胞ニッチの神経系制御におけるビタミンD受容体の役割

川森有里子
臨床血液 53(6), 571-579, 2012-06-30
NAID 10030831420

第72回日本血液学会学術集会学会奨励賞受賞論文造血幹細胞ニッチの神経系制御におけるビタミンD受容体の役割

川森有里子
臨床血液 53(6), 571-579, 2012-06
NAID 40019373739

EGFRシグナル伝達阻害によるG-CSF誘導性造血幹細胞動員の増強

塚本祥吉,中世古知昭
血液内科 63(5), 580-585, 2011-11
NAID 40019086862

Related Pictures

★リンクテーブル★

リンク元	「顆粒球コロニー刺激因子受容体」「顆粒球コロニー刺激因子レセプター」「G-CSF受容体」「G-CSFレセプター」「granulocyte colony-stimulating factor receptor」
関連記事	「CS」「C」「CSF」「G」「CSF receptor」

「顆粒球コロニー刺激因子受容体」

Colony stimulating factor 3 receptor (granulocyte)
	; PDB rendering based on 2d9q.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1AZ7, 2D9Q
Identifiers
Symbols	CSF3R ; CD114; GCSFR
External IDs	OMIM: 138971 MGI: 1339755 HomoloGene: 601 ChEMBL: 1996 GeneCards: CSF3R Gene
Gene ontology
Molecular function	• receptor activity; • cytokine receptor activity; • protein binding;
Cellular component	• extracellular region; • integral component of plasma membrane;
Biological process	• defense response; • cell adhesion; • signal transduction; • cytokine-mediated signaling pathway; • neutrophil chemotaxis; • odontogenesis of dentin-containing tooth;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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