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- British pathologist who isolated and purified penicillin, which had been discovered in 1928 by Sir Alexander Fleming (1898-1968) (同)Howard Florey, Sir Howard Walter Florey
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/12 17:07:58」(JST)
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Florey may refer to several people:
- Howard Walter Florey, Nobel Prize-winning Australian pharmacologist
- Electoral district of Florey, is a state electoral district in South Australia named after Florey.
- Robert Florey, French screenwriter and film director
Florey may also refer to several places:
- Florey, Australian Capital Territory, suburb of Canberra, Australia named after Howard Florey
- Combe Florey, village in Somerset, England
Florey may also refer to several other topics:
- Howard Florey Institute, medical research institute named after Howard Florey
English Journal
- Learning to breathe: Habituation of Hering-Breuer inflation reflex emerges with postnatal brainstem maturation.
- Dutschmann M1, Bautista TG2, Mörschel M3, Dick TE4.Author information 1Florey Institute of Neuroscience and Mental Health, Melbourne, Australia; Bernstein Center for Computational Neurosciences, Göttingen, Germany. Electronic address: mathias.dutschmann@florey.edu.au.2Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.3Bernstein Center for Computational Neurosciences, Göttingen, Germany.4Department of Medicine, Case Western Reserve University, Cleveland, USA.AbstractThe Hering-Breuer (HBR) reflex is considered a major regulatory feedback for the generation and patterning of respiratory activity. While HBR is important in neonates, its significance in adults is controversial. Previous experiments that investigated the plasticity of entrainment of the respiratory rhythm by vagal input demonstrated postnatal changes in HBR plasticity. Here we analyzed postnatal changes in the plasticity of HBR by mimicking the classic lung inflation tests with repetitive tonic vagal stimulation across different postnatal stages in an in situ perfused brainstem preparation of rat. The study shows that neonates stereotypically exhibit HBR stimulus-dependent prolongation of expiration while juvenile preparations (>postnatal day 16) showed significant habituation of HBR following repetitive stimulation. Subsequent experiments employing physiological lung inflation tests in situ confirmed HBR habituation in juveniles. We conclude that postnatal emergence of HBR habituation explains the weak contribution and high activation threshold of HBR in the regulation of eupnea.
- Respiratory physiology & neurobiology.Respir Physiol Neurobiol.2014 May 1;195:44-9. doi: 10.1016/j.resp.2014.02.009. Epub 2014 Feb 22.
- The Hering-Breuer (HBR) reflex is considered a major regulatory feedback for the generation and patterning of respiratory activity. While HBR is important in neonates, its significance in adults is controversial. Previous experiments that investigated the plasticity of entrainment of the respiratory
- PMID 24566392
- A novel approach to rapidly prevent age-related cognitive decline.
- Adlard PA1, Sedjahtera A, Gunawan L, Bray L, Hare D, Lear J, Doble P, Bush AI, Finkelstein DI, Cherny RA.Author information 1The Florey Institute of Neuroscience and Mental Health, Kenneth Myer Building, At Genetics Lane on Royal Parade, The University of Melbourne, Melbourne, Vic., 3010, Australia.AbstractThe loss of cognitive function is a pervasive and often debilitating feature of the aging process for which there are no effective therapeutics. We hypothesized that a novel metal chaperone (PBT2; Prana Biotechnology, Parkville, Victoria, Australia) would enhance cognition in aged rodents. We show here that PBT2 rapidly improves the performance of aged C57Bl/6 mice in the Morris water maze, concomitant with increases in dendritic spine density, hippocampal neuron number and markers of neurogenesis. There were also increased levels of specific glutamate receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and N-methyl-d-aspartate), the glutamate transporter (VGLUT1) and glutamate itself. Markers of synaptic plasticity [calmodulin-dependent protein kinase II (CaMKII) and phosphorylated CaMKII, CREB, synaptophysin] were also increased following PBT2 treatment. We also demonstrate that PBT2 treatment results in a subregion-specific increase in hippocampal zinc, which is increasingly recognized as a potent neuromodulator. These data demonstrate that metal chaperones are a novel approach to the treatment of age-related cognitive decline.
- Aging cell.Aging Cell.2014 Apr;13(2):351-9. doi: 10.1111/acel.12178. Epub 2013 Dec 4.
- The loss of cognitive function is a pervasive and often debilitating feature of the aging process for which there are no effective therapeutics. We hypothesized that a novel metal chaperone (PBT2; Prana Biotechnology, Parkville, Victoria, Australia) would enhance cognition in aged rodents. We show h
- PMID 24305557
- The mGlu5 receptor regulates extinction of cocaine-driven behaviours.
- Bird MK1, Lohmann P2, West B1, Brown RM3, Kirchhoff J1, Raymond CR2, Lawrence AJ4.Author information 1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.2The John Curtin School of Medical Research & Eccles Institute of Neuroscience, Australian National University, Canberra, Australia.3Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia; Medical University of South Carolina, Charleston, SC, USA.4Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia. Electronic address: andrew.lawrence@florey.edu.au.AbstractBACKGROUND: There is extensive evidence implicating the metabotropic glutamate 5 (mGlu5) receptor in aspects of addiction-related behaviours.
- Drug and alcohol dependence.Drug Alcohol Depend.2014 Apr 1;137:83-9. doi: 10.1016/j.drugalcdep.2014.01.017. Epub 2014 Jan 31.
- BACKGROUND: There is extensive evidence implicating the metabotropic glutamate 5 (mGlu5) receptor in aspects of addiction-related behaviours.METHODS: Here, we used a well-characterized line of mGlu5-deficient mice to further examine the role of this receptor in cocaine-driven behaviours. We confirme
- PMID 24576814
Japanese Journal
- Conventional Concepts and New Perspectives for Understanding the Addictive Properties of Inhalants
- Duncan Jhodie Rubina,Lawrence Andrew John
- Journal of Pharmacological Sciences 122(4), 237-243, 2013
- The abuse of inhaled chemical vapors is a growing problem especially among adolescent populations. This is partly driven by the fact that inhaled products are cheap, accessible, and provide a rapid 'h …
- NAID 130003362731
- Behavioural and Anatomical Characterization of Mutant Mice With Targeted Deletion of D₁ Dopamine Receptor–Expressing Cells : Response to Acute Morphine
- Daniela Babovic,Jiang Luning,Goto Satoshi [他],Gantois Ilse,Schütz Günter,Lawrence Andrew J.,Waddington John L.,Drago John
- Journal of Pharmacological Sciences 121(1), 39-47, 2013
- Considerable topographic overlap exists between brain opioidergic and dopaminergic neurons. Pharmacological blockade of the dopamine D1 receptor (Drd1a) reverses several behavioural phenomena elicited …
- NAID 130003362671
- Constitutive and Conditional Mutant Mouse Models for Understanding Dopaminergic Regulation of Orofacial Movements : Emerging Insights and Challenges
- Tomiyama Katsunori,Drago John,Waddington John L. [他],KOSHIKAWA Noriaki
- Journal of pharmacological sciences 119(4), 297-301, 2012-08-20
- Among numerous mechanisms implicated in the regulation of orofacial movements, dopamine-containing neurons have received the most extensive study. Here we review the effects of a) constitutive knockou …
- NAID 10031071241
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- Please help the Florey find a cure so kids with NP-C have a future. Read more To donate Parkinson's disease Professor Mal Horne's lecture on the 'non-motor' problems of Parkinson's Disease is now available to view. Video now ...
- The personal portfolio site of Florey ... North by Northwest North by Northwest. 2015 Graphic Design, Illustration Monsters Inc. Monsters Inc. 2015 Graphic Design, Illustration Robin Hood Robin Hood.
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