Fas-associated death domain

Fas関連デスドメイン

関

FADD

WordNet

1. having partial rights and privileges or subordinate status; "an associate member"; "an associate professor"
2. a person who joins with others in some activity or endeavor; "he had to consult his associate before continuing"
3. a person with subordinate membership in a society, institution, or commercial enterprise; "associates in the law firm bill at a lower rate than do partners"
4. any event that usually accompanies or is closely connected with another; "first was the lightning and then its thunderous associate"
5. make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all" (同)tie_in, relate, link, colligate, link up, connect
6. the time when something ends; "it was the death of all his plans"; "a dying of old hopes" (同)dying, demise
7. the time at which life ends; continuing until dead; "she stayed until his death"; "a struggle to the last" (同)last
8. the absence of life or state of being dead; "he seemed more content in death than he had ever been in life"
9. the permanent end of all life functions in an organism or part of an organism; "the animal died a painful death"
10. the act of killing; "he had two deaths on his conscience"
11. the event of dying or departure from life; "her death came as a terrible shock"; "upon your decease the capital will pass to your grandchildren" (同)decease, expiry
12. territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land" (同)demesne, land
13. (mathematics) the set of values of the independent variable for which a function is defined (同)domain of a function
14. the 6th letter of the Roman alphabet (同)f

PrepTutorEJDIC

1. 〈人〉'を'(…の)『仲間に加える』,(…に)連合させる《+『名』〈人〉+『with』+『名』》 / (…と)…'を'結びつけて考える(起こす)《+『名』+『with』+『名』》 / (…と)『仲間になる』,交際する《+『with』+『名』》 / (…と)合体する,提携する《+『with』+『名』》 / 『仲間』,『同僚』;組合員 / 準会員 / 付属物;連想されるもの / 連合した;仲間の,同僚の / 補助の,準…
2. 〈U〉〈C〉『死』,死亡;死に方,死にざま / 〈U〉死んだ[ような]状体 / 《the~》(…の)絶滅,破滅《+『of』+『名』》 / 《the~》(…の)死の原因,命取り《+『of』+『名』》 / 《通例『D-』》死神(手に鎌(かマ)を持った黒装束の骸骨(がいこつ)で表される)
3. (国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)

UpToDate Contents

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• 1. 自己免疫性リンパ増殖症候群(ALPS)：疫学および病因autoimmune lymphoproliferative syndrome alps epidemiology and pathogenesis [show details]
  … Exon 9 contains the death domain (ICD-DD) that interacts with an adaptor molecule, Fas-associated via death domain (FADD). FADD binding to ICD-DD leads to generation of the death-inducing signaling complex …
• 2. アポトーシスと自己免疫疾患apoptosis and autoimmune disease [show details]
  …in the recruitment of adaptor molecules (eg, Fas-associated protein with death domain [FADD] and tumor necrosis factor receptor type I-associated death domain protein [TRADD]) . The adaptor molecules subsequently …
• 3. 自己免疫性リンパ増殖症候群(ALPS)：臨床的特徴および診断autoimmune lymphoproliferative syndrome alps clinical features and diagnosis [show details]
  … ALPS due to mutations in the Fas cell surface death receptor (FAS) gene that encodes an apoptosis-associated antigen (ALPS-FAS) is the most common and best-characterized… and 17 of 18 cases occurred in patients with mutations affecting the death domain of Fas.…
• 4. 細胞性免疫応答the adaptive cellular immune response t cells and cytokines [show details]
  …activation-induced cell death (AICD) . The same signals that lead to activation also set in motion a program of cell death (apoptosis) that may eventually kill the cell. Two important receptors promoting death of activated… T cells are Fas (CD95, which binds Fas ligand [FasL]) and tumor necrosis factor (TNF) receptor 2 (TNFR2 or CD120b,… histocompatibility complex (MHC) antigen with which it becomes associated to stimulate peptide-specific T cells.…
• 5. 自己免疫性リンパ増殖症候群(ALPS)：管理および予後autoimmune lymphoproliferative syndrome alps management and prognosis [show details]
  … affecting the intracellular death domain of the Fas molecule may have a poorer prognosis, while those with defects in the extracellular domain may have more mild disease.… particularly in children, without complications. For example, long-term use of glucocorticoids is associated with obesity, growth retardation, hypertension, cataracts, osteopenia/osteoporosis leading to pathologic …

English Journal

• Apoptosis induced by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS generation through both extrinsic and intrinsic apoptosis pathways.

• Zhao J, Bowman L, Magaye R, Leonard SS, Castranova V, Ding M.SourceDepartment of Preventive Medicine of the Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
• International journal of oncology.Int J Oncol.2013 Apr;42(4):1349-59. doi: 10.3892/ijo.2013.1828. Epub 2013 Feb 15.
• In this study, apoptosis and related signaling induced by WC-Co nanoparticles were investigated in JB6 cells and rat lung macrophages. Electron spin resonance (ESR) and fluorescent staining indicated that both WC-Co nanoparticles and fine particles stimulated reactive oxygen species (ROS) generati
• PMID 23417053

• Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway.

• Mou H, Li Z, Yao P, Zhuo S, Luan W, Deng B, Qian L, Yang M, Mei H, Le Y.SourceKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
• The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2013 Mar;45(3):684-91. doi: 10.1016/j.biocel.2012.12.003. Epub 2012 Dec 12.
• FAM3B, also named PANDER, is a cytokine-like protein identified in 2002. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B is also expressed by other tissues but its basic function is unclear. In this study, we foun
• PMID 23246487

• Structural insight for the roles of fas death domain binding to fadd and oligomerization degree of the fas-fadd complex in the death-inducing signaling complex formation: A computational study.

• Yan Q, McDonald JM, Zhou T, Song Y.SourceDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, Alabama 35294.
• Proteins.Proteins.2013 Mar;81(3):377-85. doi: 10.1002/prot.24193. Epub 2012 Nov 5.
• Fas binding to Fas-associated death domain (FADD) activates FADD-caspase-8 binding to form death-inducing signaling complex (DISC) that triggers apoptosis. The Fas-Fas association exists primarily as dimer in the Fas-FADD complex, and the Fas-FADD tetramer complexes have the tendency to form higher
• PMID 23042204

Japanese Journal

• Induction of Apoptosis by Icariside Ⅱ through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

• HUANG Chaoqing,CHEN Xiaoguang,GUO Baolin [他],HUANG Wenhua,SHEN Ting,SUN Xinguang,XIAO Peigen,ZHOU Qing
• Bioscience, biotechnology, and biochemistry 76(7), 1322-1328, 2012-07-23
• … In contrast, IcaS enhanced the expression level of Fas and the Fas-associated death domain (FADD), and activated caspase-8, suggesting the involvement of the extrinsic apoptosis pathway. …
• NAID 10030981920

• Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection

• Kosai Kosuke,Seki Masafumi,Tanaka Akitaka [他],Morinaga Yoshitomo,Imamura Yoshifumi,Izumikawa Koichi,Kakeya Hiroshi,Yamamoto Yoshihiro,Yanagihara Katsunori,Tomono Kazunori,Kohno Shigeru
• Japanese Journal of Infectious Diseases 64(6), 451-457, 2011-11
• … Furthermore, Fas-associated death domain was significantly expressed in the lungs of co-infected mice 24 h after S. …
• NAID 40019126090

• DIC診療における現状の問題点と今後の展望 (特集 変貌するDICの診断と治療) -- (臨床編)

• 松田 直之
• Thrombosis medicine 1(1), 73-76, 2011-08
• NAID 40019352591

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★リンクテーブル★

リンク元	「FADD」「Fas関連デスドメイン」
拡張検索	「Fas-associated death domain protein」
関連記事	「associate」「FAS」「domain」「associated」「F」

「FADD」

　　[★] Fas関連デスドメイン Fas-associated death domain

「Fas関連デスドメイン」

　　[★]

英

Fas-associated death domain、FADD

「Fas-associated death domain protein」

　　[★]

Fas結合デスドメインタンパク質

関

FADD protein

「associate」

　　[★]

• vt.

• 結合する、連合させる。連想によって結びつける。(人を)仲間/友達などとしての関係に置く。(化)会合させる

• vi.

• 仲間/友人などとして交際する(with)。一つにまとめる、連合する

• n.

• 仕事仲間、提携者、同僚。友人、朋友。準会員。従業員、社員
• 密接な蒸す偽付きのある物、付随する物、つきもの。準国家
• 連想によって心に浮かぶ言葉/思い、連想物

• adj.

• 仲間の、同僚の。製紙機械員に次ぐ資格の
• 付随する、連想される

関

accompany、association、associative、attach、bearing、bind、binding、bond、bonding、coassemble、colleague、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、correlate、correlation、couple、dock、engage、engagement、federation、implication、join、joint、ligate、link、linkage、peer、pertinent、reference、relate、relation、relationship、relative、relevance、relevant、symphysial、union

　 　 　 　 　 　

「FAS」

　　[★]

• 胎児性アルコール症候群 fetal alcohol syndrome
• 脂肪酸合成酵素 fatty acid synthetase：fatty acid synthetase 1、fatty acid synthetase 2
• (アポトーシスに関連)CD95 Fas

「domain」

　　[★]

• n.

• ドメイン、(分子内の)領域、分域

関

area、realm、region、regional、segregation、territory、universe

　 　 　

「associated」

　　[★]

• adj.

• 随伴の、随伴性の

関

concomitant、erratic、erratically

associate

「F」

　　[★] フェニルアラニン phenylalanine