WordNet

to an advanced stage or point; "a young man who will go very far"
at or to a certain point or degree; "I can only go so far before I have to give up"; "how far can we get with this kind of argument?"
at or to or from a great distance in space; "he traveled far"; "strayed far from home"; "sat far away from each other"
being of a considerable distance or length; "a far trek"
being the animal or vehicle on the right or being on the right side of an animal or vehicle; "the horse on the right is the far horse"; "the right side is the far side of the horse"
beyond a norm in opinion or actions; "the far right"
located at a great distance in time or space or degree; "we come from a far country"; "far corners of the earth"; "the far future"; "a far journey"; "the far side of the road"; "far from the truth"; "far in the future"
remote in time; "if we could see far into the future"; "all that happened far in the past"
to a considerable degree; very much; "a far far better thing that I do"; "felt far worse than yesterday"; "eyes far too close together"
make a sound like a clock or a timer; "the clocks were ticking"; "the grandfather clock beat midnight" (同)ticktock, ticktack, beat
a light mattress
any of two families of small parasitic arachnids with barbed proboscis; feed on blood of warm-blooded animals
a metallic tapping sound; "he counted the ticks of the clock" (同)ticking
sew; "tick a mattress" (同)retick
a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
relating to or characteristic of regions of eastern parts of the world; "Eastern Europe"; "the Eastern religions"
lying toward or situated in the east; "the eastern end of the island"
of or characteristic of eastern regions of the United States; "the Eastern establishment"
shrub with terminal tufts of elongated leaves used locally for thatching and clothing; thick sweet roots are used as food; tropical southeastern Asia, Australia and Hawaii (同)Cordyline terminalis
the syllable naming the seventh (subtonic) note of any musical scale in solmization (同)te, si

PrepTutorEJDIC

《距離》『遠くに』,遠くへ,はるかに / 《時間》『ずっと後まで(に),ずっと先まで(に)』 / 《程度》《形容詞・副詞[句],およびその比較級を修飾して》『ずっと』,はるかに(much),たいそう / 《おもに文・詩》(場所が)『遠くにある』,遠い / (二つのうち)『遠いほうの』,向こう側の / 長距離(長時間)にわたる / (政治的に)極端な
(時計まどの)カチカチ[という音] / 《英語》瞬間 / 照合(点検)済みの印,チェック / 〈時計などが〉カチカチ音がする《+away》 / 〈時が〉過ぎる,経過する∥+by(away)》 / 《話》〈人が〉行動する,〈機械などが〉動く
〈C〉(ふとん・まくらなどの)表布
ダニ
ビールス,ろ過性病原体
『東の』;東へ向かう;(風が)東からの / 《しばしばEastern》『東洋の』(Oriental) / 《しばしばEastern》《米》東部地方の / 《Eastern》東欧の,共産圏の
シ(全音階の第7音)

UpToDate Contents

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1. 節足動物媒介性脳炎 arthropod borne encephalitides
2. ウイルス性髄膜炎：小児におけるマネージメント、予後、および予防 viral meningitis management prognosis and prevention in children
3. セントルイス脳炎 st louis encephalitis
4. 小児の急性ウイルス性脳炎：治療と予防 acute viral encephalitis in children treatment and prevention
5. ライム病の治療 treatment of lyme disease

English Journal

In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses.

Lo MK1, Shi PY2, Chen YL3, Flint M4, Spiropoulou CF5.
Antiviral research.Antiviral Res.2016 Jun;130:46-9. doi: 10.1016/j.antiviral.2016.03.013. Epub 2016 Mar 23.
There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we desc
PMID 27016316

Insect-specific flaviviruses, a worldwide widespread group of viruses only detected in insects.

Calzolari M1, Zé-Zé L2, Vázquez A3, Sánchez Seco MP4, Amaro F5, Dottori M6.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.Infect Genet Evol.2016 Jun;40:381-8. doi: 10.1016/j.meegid.2015.07.032. Epub 2015 Jul 31.
Several flaviviruses are important pathogens for humans and animals (Dengue viruses, Japanese encephalitis virus, Yellow-fever virus, Tick-borne encephalitis virus, West Nile virus). In recent years, numerous novel and related flaviviruses without known pathogenic capacity have been isolated worldwi
PMID 26235844

Expression of a second open reading frame present in the genome of tick-borne encephalitis virus strain Neudoerfl is not detectable in infected cells.

Černý J1,2,3, Selinger M4,5, Palus M4,5,6, Vavrušková Z4, Tykalová H4,5, Bell-Sakyi L7, Štěrba J4,5, Grubhoffer L4,5, Růžek D4,6.
Virus genes.Virus Genes.2016 Jun;52(3):309-16. doi: 10.1007/s11262-015-1273-y. Epub 2016 Feb 29.
A short upstream open reading frame (uORF) was recently identified in the 5' untranslated region of some tick-borne encephalitis virus (TBEV) strains. However, it is not known if the peptide encoded by TBEV uORF (TuORF) is expressed in infected cells. Here we show that TuORF forms three phylogenetic
PMID 26924586

Japanese Journal

The variable region of the 3' untranslated region is a critical virulence factor in the Far-Eastern subtype of tick-borne encephalitis virus in mouse model

Sakai Mizuki,Yoshii Kentaro,Sunden Yuji,Yokozawa Kana,Hirano Minato,Kariwa Hiroaki
Journal of General Virology 95(4), 823-835, 2014-04
… Tick-borne encephalitis virus (TBEV) is a major arbovirus that causes thousands of cases of severe neurological illness in humans annually. … To identify the virulence factors, we constructed chimeric viruses between two TBEV strains of the Far-Eastern subtype, Sofjin-HO (highly pathogenic) and Oshima 5-10 (low pathogenic). …
NAID 120005575003

Pathologic Potential of Variant Clones of the Oshima Strain of Far-Eastern Subtype Tick-Borne Encephalitis Virus

, , , , ,
Tropical Medicine and Health 42(1), 15-23, 2014
… Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes acute central nervous system (CNS) disease in humans. … However, we did not examine the influence of virus variants in the previous study. … We isolated eight variant clones from the stock virus of the Oshima 5-10. …
NAID 130003392440

Genetic and Biological Characterization of Tick-Borne Encephalitis Virus Isolated from Wild Rodents in Southern Hokkaido, Japan in 2008

Kentaro Yoshii,Yamazaki Shoko,Mottate Keita,Nagata Noriyo,Seto Takahiro,Sanada Takashiro,Sakai Mizuki,Kariwa Hiroaki,Takashima Ikuo
Vector-Borne
… Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis in humans. … One virus, designated Oshima 08-As, was isolated from an Apodemus speciosus captured in Hokuto in 2008. … Oshima 08-As was classified as the Far Eastern subtype of TBEV and formed a cluster with the other strains isolated in Hokkaido from 1995 to 1996. …
NAID 120005307921