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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/13 11:10:16」(JST)

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Floxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colorectal cancer.

Pharmacology

Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine.

Mechanism of action

Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.

History

Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-fluorouracil. The National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to F H Faulding, which became Mayne Pharma.

Suppliers

In the US the drug is supplied by APP Pharmaceuticals, LLC; Hospira, Inc.; and Bedford Laboratories.

UpToDate Contents

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1. 大腸癌の肝転移に対する非外科的局所治療戦略 nonsurgical local treatment strategies for colorectal cancer liver metastases
2. 抵抗性または再発性の妊娠性絨毛腫瘍のマネージメント management of resistant or recurrent gestational trophoblastic neoplasia
3. 肝疾患を有する患者における化学療法による肝毒性および用量調整 chemotherapy hepatotoxicity and dose modification in patients with liver disease
4. 切除可能大腸癌の肝転移のマネージメント management of potentially resectable colorectal cancer liver metastases
5. 限局進行性胆管癌に対する治療選択肢 treatment options for locally advanced cholangiocarcinoma

English Journal

Hepatic Arterial Infusion in Combination with Modern Systemic Chemotherapy is Associated with Improved Survival Compared with Modern Systemic Chemotherapy Alone in Patients with Isolated Unresectable Colorectal Liver Metastases: A Case-Control Study.

Dhir M1, Jones HL1, Shuai Y2, Clifford AK1, Perkins S1, Steve J1, Hogg ME1, Choudry MH1, Pingpank JF1, Holtzman MP1, Zeh HJ 3rd1, Bahary N3, Bartlett DL1, Zureikat AH4.
Annals of surgical oncology.Ann Surg Oncol.2017 Jan;24(1):150-158. doi: 10.1245/s10434-016-5418-6. Epub 2016 Jul 18.
BACKGROUND: In the era of effective modern systemic chemotherapy (CT), the role of hepatic arterial infusion of fluoxuridine (HAI-FUDR) in the treatment of isolated unresectable colorectal liver metastasis (IU-CRCLM) remains controversial. This study aimed to compare the overall survival (OS) of HAI
PMID 27431415

Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.

Baehr CA1, Huntoon CJ1,2, Hoang SM1, Jerde CR1, Karnitz LM3,2,4.
The Journal of biological chemistry.J Biol Chem.2016 Dec 23;291(52):26875-26885. doi: 10.1074/jbc.M116.746081. Epub 2016 Nov 14.
Uracil N-glycosylase 2 (UNG2), the nuclear isoform of UNG, catalyzes the removal of uracil or 5-fluorouracil lesions that accumulate in DNA following treatment with the anticancer agents 5-fluorouracil and 5-fluorodeoxyuridine (floxuridine), a 5-fluorouracil metabolite. By repairing these DNA lesion
PMID 27875297

Intra-arterial therapies for colorectal cancer liver metastases (radioembolization excluded).

de Baere T1, Tselikas L2, Boige V2, Ducreux M2, Malka D2, Goéré D2, Benahim E2, Deschamps F2.
Bulletin du cancer.Bull Cancer.2016 Dec 16. pii: S0007-4551(16)30350-2. doi: 10.1016/j.bulcan.2016.10.025. [Epub ahead of print]
During the past 20 years, advances in systemic therapies have improved overall survival of patients with Colorectal cancer Liver metastases (CRLM) from 6 to 24 months. By reaching CRLM via their preferential arterial vascularization, hepatic arterial infusion of chemotherapy (HAIC) has demonstrate
PMID 27993355

Japanese Journal

大腸癌肝転移に対する動注化学療法 (特集大腸癌肝転移up to date) -- (非手術療法)

伊藤寛倫
外科 75(8), 822-827, 2013-08
NAID 40019752005

Interaction of Intestinal Nucleoside Transporter hCNT2 with Amino Acid Ester Prodrugs of Floxuridine and 2-Bromo-5,6-dichloro-1-β-D-ribofuranosylbenzimidazole(Pharmacology)

Shin Ho-Chul,Kim Jin-Suk,Vig Balvinder Singh [他],SONG Xueqin,DRACH John Charles,AMIDON Gordon Lewis
Biological & pharmaceutical bulletin 29(2), 247-252, 2006-02-01
… We studied the interaction of human concentrative nucleoside transporter (hCNT2) cloned from intestine with various amino acid ester prodrugs of floxuridine (FUdR) and 5,6-dichloro-2-bromo-1-β-D-ribofuranosylbenzimidazole (BDCRB). … FUdR significantly inhibited the uptake of both [^3H]-inosine and [^3H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibited markedly decreased inhibition potency (10-30% of control). …
NAID 110005663953

PS-190-3 FUDR(2'-deoxy-5-fluorouridine)腹腔内化学療法における急速投与と持続投与の比較

井上健太郎,中根恭司,佐藤睦哉,中井宏治,道浦拓,田中義人,神原達也,山道啓吾,上山泰男
日本外科学会雑誌 105(臨時増刊), 632, 2004-03-15
NAID 110003962709

Related Pictures

FUDR – Page 4 – Friends of the Upper Delaware River [FuDr_HMW20] Battery Invaders - LoFi-Entertainment Part I : Battery Invaders : Free エフユーディーアール(FUDR)の個人輸入代行 - フロクスウリジン [FuDr 20] Various - Re:Wired : Various : Free Download, Borrow, and Streaming [FuDr 15] Roastboqs - S.T. : Roastboqs : Free Download, Borrow, and Streaming Floxuridina; Fluorodeoxiuridina; FUdR [FuDr 14] Au:Cell - Kammor [The Audiopics] : Au:Cell : Free Download & Streaming FuDr_HMW23 Isora . Lifeworld Of Technology – Futuredraht

★リンクテーブル★

リンク元	「5-フルオロデオキシウリジン」
拡張検索	「5-FUdR」
関連記事	「FU」

「5-フルオロデオキシウリジン」

Floxuridine
Systematic (IUPAC) name
	5-Fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682006
Pregnancy; category	(US): D;
Routes of; administration	Intra-arterial
Identifiers
CAS Registry Number	50-91-9
ATC code	None
PubChem	CID: 5790
IUPHAR/BPS	4801
DrugBank	DB00322
ChemSpider	5586
UNII	039LU44I5M
KEGG	D04197
ChEBI	CHEBI:60761
ChEMBL	CHEMBL917
Chemical data
Formula	C9H11FN2O5
Molecular mass	246.192 g/mol
	SMILES FC=1C(=O)NC(=O)N(C=1)[C@@H]2O[C@@H]([C@@H](O)C2)CO ;
	InChI InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 ; Key:ODKNJVUHOIMIIZ-RRKCRQDMSA-N ;
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