WordNet
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- 蛋白(たんばく)質
UpToDate Contents
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- 1. 成人肝移植における免疫抑制の概要 overview of immunosuppression in adult liver transplantation
- 2. 移植片対宿主病の予防および治療に使用される免疫抑制剤の概要 overview of immunosuppressive agents used for prevention and treatment of graft versus host disease
- 3. 2型糖尿病の病因 pathogenesis of type 2 diabetes mellitus
- 4. 成人の腎移植における免疫抑制維持療法 maintenance immunosuppressive therapy in renal transplantation in adults
- 5. シクロスポリンおよびタクロリムスの薬理作用および副作用 pharmacology and side effects of cyclosporine and tacrolimus
English Journal
- Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.
- Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, Binder EB.SourceMax Planck Institute of Psychiatry, Munich, Germany.
- Nature neuroscience.Nat Neurosci.2012 Dec 2. doi: 10.1038/nn.3275. [Epub ahead of print]
- Although the fact that genetic predisposition and environmental exposures interact to shape development and function of the human brain and, ultimately, the risk of psychiatric disorders has drawn wide interest, the corresponding molecular mechanisms have not yet been elucidated. We found that a fun
- PMID 23201972
- Differences in FKBP51 Regulation Following Chronic Social Defeat Stress Correlate with Individual Stress Sensitivity: Influence of Paroxetine Treatment.
- Wagner KV, Marinescu D, Hartmann J, Wang XD, Labermaier C, Scharf SH, Liebl C, Uhr M, Holsboer F, Müller MB, Schmidt MV.SourceMax Planck Institute of Psychiatry, Munich, Germany.
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.Neuropsychopharmacology.2012 Dec;37(13):2797-808. doi: 10.1038/npp.2012.150. Epub 2012 Aug 8.
- Various clinical studies have identified FK506-binding protein 51 (FKBP51) as a target gene involved in the development of psychiatric disorders such as depression. Furthermore, FKBP51 has been shown to affect glucocorticoid receptor signaling by sensitivity modulation and it is implicated in stress
- PMID 22871917
Japanese Journal
- 磁気共鳴を使った真核細胞内タンパク質の構造・機能解析 (未来型ナノ診断・治療への分析化学からの挑戦)
- 杤尾 豪人,白川 昌宏
- 薬学雑誌 132(2), 185-193, 2012
- NAID 40019192267
- An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR
- Sekiguchi Mitsuhiro,Kobashigawa Yoshihiro,Kawasaki Masashi,Yokochi Masashi,Kiso Tetsuo,Suzumura Ken-ichi,Mori Keitaro,Teramura Toshio,Inagaki Fuyuhiko
- Protein
- … Mammalian target of rapamycin (mTOR), a large multi-domain protein kinase, regulates cell growth and metabolism in response to environmental signals. … The FKBP rapamycin-binding (FRB) domain of mTOR is a validated therapeutic target for the development of immunosuppressant and anticancer drugs but is labile and insoluble. … Here we designed a fusion protein between FKBP12 and the FRB domain of mTOR. …
- NAID 80022226016
Related Links
- FK506に結合する蛋白質であるFKBP (FK506-binding protein) は、原核細胞生物 から真核細胞生物まで殆どの生物種に存在しており、生体内の機能分子である蛋白質 の主鎖の向きを大きく変換することのできる酵素活性 (peptidyl prolyl cis/trans isomerase ...
- タクロリムスは細胞内でまずFKBP (FK506 binding protein) と複合体を形成し、これが さらにカルシニューリンに結合する。そしてそのNFAT脱リン酸化反応を阻害すること により、IL-2に代表される種々のサイトカインの発現を抑制する。これにより、細胞傷害性 T ...
Related Pictures
★リンクテーブル★
| リンク元 | 「FK506結合タンパク質」「FKBP」「tacrolimus-binding protein」 |
| 関連記事 | 「binding」「binding protein」 |
「FK506結合タンパク質」
-FKBP
「FKBP」
「tacrolimus-binding protein」
「binding」
- n.
- adj.
- 結合性の
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union