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the 6th letter of the Roman alphabet (同)f

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/20 17:04:57」(JST)

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Basic fibroblast growth factor, also known as bFGF, FGF2 or FGF-β,^[1] is a member of the fibroblast growth factor family.^[2]

Function[edit]

In normal tissue, basic fibroblast growth factor is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide.

It has been hypothesized that, during both wound healing of normal tissues and tumor development, the action of heparan sulfate-degrading enzymes activates bFGF, thus mediating the formation of new blood vessels, a process known as angiogenesis.

In addition, it is synthesized and secreted by human adipocytes and the concentration of bFGF correlates with the BMI in blood samples. In this study, bFGF was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase.^[3]

bFGF has been shown in preliminary animal studies to protect the heart from injury associated with a heart attack, reducing tissue death and promoting improved function after reperfusion.^[4]

Recent evidence has shown that low levels of FGF2 play a key role in the incidence of excessive anxiety.^{[citation needed]}

Additionally, bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined. It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins.^[5] It is necessary in mouse-feeder cell dependent culture systems, as well as in feeder and serum-free culture systems.^[6] FGF2, in conjunction with BMP4, promote differentiation of stem cells to mesodermal lineages. After differentiation, BMP4 and FGF2 treated cells generally produces higher amounts of osteogenic and chondorgenic differentiation than untreated stem cells.^[7]

Interactions[edit]

Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1,^[8] RPL6^[9] and ribosomal protein S19.^[10]

References[edit]

^ Horst Ibelgaufts' COPE: FGF-beta
^ Kim HS (1998). "Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping". Cytogenet. Cell Genet. 83 (1-2): 73. doi:10.1159/000015129. PMID 9925931.
^ Kühn MC, Willenberg HS, Schott M, Papewalis C, Stumpf U, Flohé S, Scherbaum WA, Schinner S. (2012). "Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation.". Mol Cell Endocrinol. 349 (2): 180–188. doi:10.1016/j.mce.2011.10.018. PMID 22040599.
^ House SL, Bolte C, Zhou M, Doetschman T, Klevitsky R, Newman G, Schultz Jel J. (2003). "Cardiac-specific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of low-flow ischemia.". Circulation 108 (1): 3140–3148. doi:10.1161/01.CIR.0000105723.91637.1C. PMID 14656920.
^ Pereira RC, Economides AN, Canalis E (December 2000). "Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts". Endocrinology 141 (12): 4558–63. doi:10.1210/en.141.12.4558. PMID 11108268.
^ Liu Y, Song Z, Zhao Y, Qin H, Cai J, Zhang H, Yu T, Jiang S, Wang G, Ding M, Deng H (2006). "A novel chemical-defined medium with bFGF and N2B27 supplements supports undifferentiated growth in human embryonic stem cells". Biochem Biophys Res Commun 346 (1): 131–9. doi:10.1016/j.bbrc.2006.05.086. PMID 16753134.
^ Lee, T. J.; Jang, J.; Kang, S.; Jin, M.; Shin, H.; Kim, D. W.; Kim, B. S. (2013). "Enhancement of osteogenic and chondrogenic differentiation of human embryonic stem cells by mesodermal lineage induction with BMP-4 and FGF2 treatment". Biochemical and Biophysical Research Communications 430 (2): 793–797. doi:10.1016/j.bbrc.2012.11.067. PMID 23206696. edit
^ Skjerpen, Camilla Skiple; Nilsen Trine, Wesche Jørgen, Olsnes Sjur (August 2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". EMBO J. (England) 21 (15): 4058–69. doi:10.1093/emboj/cdf402. ISSN 0261-4189. PMC 126148. PMID 12145206. Cite uses deprecated parameters (help)
^ Shen, B; Arese M, Gualandris A, Rifkin D B (November 1998). "Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107". Biochem. Biophys. Res. Commun. (UNITED STATES) 252 (2): 524–8. doi:10.1006/bbrc.1998.9677. ISSN 0006-291X. PMID 9826564. Cite uses deprecated parameters (help)
^ Soulet, F; Al Saati T, Roga S, Amalric F, Bouche G (November 2001). "Fibroblast growth factor-2 interacts with free ribosomal protein S19". Biochem. Biophys. Res. Commun. (United States) 289 (2): 591–6. doi:10.1006/bbrc.2001.5960. ISSN 0006-291X. PMID 11716516. Cite uses deprecated parameters (help)

External links[edit]

Basic Fibroblast Growth Factor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 難治性狭心症マネージメントのための血管新生療法 therapeutic angiogenesis for management of refractory angina
2. 原発性骨髄線維症における病態 pathogenetic mechanisms in primary myelofibrosis
3. 悪性神経膠腫の病因と分子生物学 pathology and molecular pathogenesis of diffuse gliomas
4. 幼児血管腫の疫学、病因、臨床的特徴、および合併症 epidemiology pathogenesis clinical features and complications of infantile hemangiomas
5. 有毛細胞白血病の臨床的特徴および診断 clinical features and diagnosis of hairy cell leukemia

English Journal

Guided bone regeneration is promoted by the molecular events in the membrane compartment.

Turri A1, Elgali I2, Vazirisani F2, Johansson A2, Emanuelsson L2, Dahlin C3, Thomsen P4, Omar O2.
Biomaterials.Biomaterials.2016 Apr;84:167-83. doi: 10.1016/j.biomaterials.2016.01.034. Epub 2016 Jan 19.
The working hypothesis of guided bone regeneration (GBR) is that the membrane physically excludes non-osteogenic tissues from interfering with bone healing. However, the underlying mechanisms are insufficiently explained. This study aimed to investigate the molecular and structural pattern of bone h
PMID 26828682

Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage.

Li W1, Du X, Chen Q, Kang Y, Xu C, Fan L, Ye H, Ying S, Shi L, Jin R, Wu J, Liang G, Li X.
Anti-cancer drugs.Anticancer Drugs.2016 Mar;27(3):164-72. doi: 10.1097/CAD.0000000000000312.
Fibroblast growth factor 2 (FGF2) is closely involved in a variety of tumors, including gastric cancer (GC). FGF2 inhibitors exert good antitumor activity, but no FGF2 inhibitor has been employed for clinical use. To obtain a low-toxicity, stable peptidomimetic (called P29) target to FGF2, the affin
PMID 26556626

Chemopreventive and hepatoprotective roles of adiponectin (SULF2 inhibitor) in hepatocelluar carcinoma.

Al-Gayyar MM, Abbas A, Hamdan AM.
Biological chemistry.Biol Chem.2016 Mar 1;397(3):257-67. doi: 10.1515/hsz-2015-0265.
Sulfatase 2 (SULF2) is an extracellular enzyme that catalyzes the removal of 6-O-sulfate groups from the heparan sulfate (HS). As elevated SULF2 activity has been correlated with hepatocellular carcinoma (HCC), this study was conducted to evaluate the chemoprotective and the hepatoprotective roles o
PMID 26733159

Japanese Journal

Effect of polyglycolic acid sheets with fibrin glue (MCFP technique) on the healing of wounds after partial resection of the border of the tongue in rabbits: a preliminary study

Yonezawa Hisanobu,Yamada Shin-ichi,Yanamoto Souichi,Yoshitomi Izumi,Kawasaki Goro,Umeda Masahiro
British Journal of Oral and Maxillofacial Surgery 50(5), 459-463, 2012-07
… Eighteen mature male Japanese white rabbits had a unilateral glossectomy involving an area 10 mm × 10 mm × 2 mm. … After glossectomy the tongues were covered with PGA sheets 8 mm × 8 mm in size and fibrin glue (mucosal defect covered with fibrin glue and polyglycolic acid sheet = MCFP) 1 week after the operation (n = 3), after 2 weeks (n = 3), and after 4 weeks (n = 3). …
NAID 120003353283

歯周炎罹患歯に対するFGF-2投与の長期的効果および安全性の検討

北村正博,古市保志,藤井健男,川浪雅光,國松和司,島内英俊,山田了,小方頼昌,和泉雄一,伊藤公一,中川種昭,新井高,山崎和久,吉江弘正,野口俊英,渋谷俊昭,高柴正悟,栗原英見,永田俊彦,横田誠,前田勝正,廣藤卓雄,坂上竜資,原宜興,野口和行,小笠原健文,村上伸也
日本歯周病学会会誌 54(1), 38-45, 2012-03-28
NAID 10030555232

Related Pictures

★リンクテーブル★

リンク元	「bFGF」「線維芽細胞増殖因子」「血管新生」「fibroblast growth factor-2」
拡張検索	「FGF-23」
関連記事	「FGF」「F」「FGFs」

「bFGF」

Fibroblast growth factor 2 (basic)
	; PDB rendering based on 1bas.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 4FGF
Identifiers
Symbols	FGF2; BFGF; FGF-2; FGFB; HBGF-2
External IDs	OMIM: 134920 MGI: 95516 HomoloGene: 1521 ChEMBL: 3107 GeneCards: FGF2 Gene
Gene Ontology
Molecular function	• fibroblast growth factor receptor binding; • cytokine activity; • protein binding; • growth factor activity; • heparin binding; • fibroblast growth factor binding; • ligand-dependent nuclear receptor transcription coactivator activity; • chemoattractant activity;
Cellular component	• extracellular region; • extracellular space; • nucleus; • cytosol;
Biological process	• activation of MAPKK activity; • activation of MAPK activity; • MAPK import into nucleus; • branching involved in ureteric bud morphogenesis; • organ induction; • positive regulation of endothelial cell proliferation; • cell migration involved in sprouting angiogenesis; • phosphatidylinositol biosynthetic process; • C21-steroid hormone biosynthetic process; • apoptotic process; • chemotaxis; • signal transduction; • epidermal growth factor receptor signaling pathway; • Ras protein signal transduction; • nervous system development; • positive regulation of cell proliferation; • negative regulation of cell proliferation; • insulin receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • organ morphogenesis; • glial cell differentiation; • negative regulation of fibroblast migration; • positive regulation of phospholipase C activity; • substantia nigra development; • positive regulation of cerebellar granule cell precursor proliferation; • hyaluronan catabolic process; • negative regulation of cell growth; • lung development; • inositol phosphate biosynthetic process; • wound healing; • positive regulation of cell fate specification; • positive regulation of blood vessel endothelial cell migration; • negative regulation of blood vessel endothelial cell migration; • positive regulation of phosphatidylinositol 3-kinase activity; • innate immune response; • positive regulation of osteoblast differentiation; • regulation of angiogenesis; • positive regulation of angiogenesis; • negative regulation of transcription, DNA-dependent; • positive regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter; • regulation of retinal cell programmed cell death; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • embryonic morphogenesis; • response to axon injury; • stem cell development; • positive chemotaxis; • release of sequestered calcium ion into cytosol; • regulation of cell cycle; • positive regulation of cell division; • positive regulation of cardiac muscle cell proliferation; • corticotropin hormone secreting cell differentiation; • thyroid-stimulating hormone-secreting cell differentiation; • negative regulation of cell death; • chondroblast differentiation; • mammary gland epithelial cell differentiation; • negative regulation of wound healing; • positive regulation of ERK1 and ERK2 cascade;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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