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- 1. Endometriosis: Long-term treatment with gonadotropin-releasing hormone agonists
- 2. 去勢感受性前立腺癌の初期全身療法 initial systemic therapy for castration sensitive prostate cancer
- 3. アンドロゲン過剰症および男性型多毛症治療におけるGnRHアゴニストの使用 use of gnrh agonists in the treatment of hyperandrogenism and hirsutism
- 4. 子宮平滑筋腫（子宮筋腫）の治療の概要 overview of treatment of uterine leiomyomas fibroids
- 5. 思春期早発症の治療 treatment of precocious puberty
English Journal
- Functional activity of the porcine Gnrhr2 gene promoter in testis-derived cells is partially conferred by nuclear factor-κB, specificity protein 1 and 3 (SP1/3) and overlapping early growth response 1/SP1/3 binding sites.
- Brauer VM1, Wiarda-Bell JR1, Desaulniers AT1, Cederberg RA1, White BR2.
- Gene.Gene.2016 Aug 10;587(2):137-46. doi: 10.1016/j.gene.2016.04.052. Epub 2016 Apr 28.
- Unlike the classical gonadotropin-releasing hormone (GnRH1), the second mammalian isoform (GnRH2) is ubiquitously expressed, suggesting a divergent function. Indeed, we demonstrated that GnRH2 governs LH-independent testosterone secretion in porcine testes via interaction with its receptor (GnRHR2)
- PMID 27134031
- Improved in vivo antitumor effect of a daunorubicin - GnRH-III bioconjugate modified by apoptosis inducing agent butyric acid on colorectal carcinoma bearing mice.
- Kapuvári B1, Hegedüs R2, Schulcz Á1, Manea M3, Tóvári J1, Gacs A1, Vincze B1, Mező G4.
- Investigational new drugs.Invest New Drugs.2016 Aug;34(4):416-23. doi: 10.1007/s10637-016-0354-7. Epub 2016 May 5.
- Compared to classical chemotherapy, peptide-based drug targeting is a promising therapeutic approach for cancer, which can provide increased selectivity and decreased side effects to anticancer drugs. Among various homing devices, gonadotropin-releasing hormone-III (GnRH-III) peptide represents a su
- PMID 27146514
- Therapeutic management of uterine fibroid tumors.
- Puchar A1, Feyeux C, Luton D, Koskas M.
- Minerva ginecologica.Minerva Ginecol.2016 Aug;68(4):466-76. Epub 2015 Dec 23.
- Fibroids, which are benign smooth-muscle tumors of clonal origin, are the most common gynecologic tumors occurring in about 20 to 25 % of women over 30 years of age. The most frequent symptoms are pelvic pain and heavy menstrual bleeding resulting in anemia. The role of fibroids in infertility remai
- PMID 26698838
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