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1. 病原性大腸菌 pathogenic escherichia coli
2. 旅行者下痢症 travelers diarrhea
3. 腸管出血性大腸菌（EHEC）の微生物学、病因、疫学、および予防 microbiology pathogenesis epidemiology and prevention of enterohemorrhagic escherichia coli ehec
4. 成人における血栓性血小板減少性紫斑病-溶血性尿毒症症候群の原因 causes of thrombotic thrombocytopenic purpura hemolytic uremic syndrome in adults
5. 微生物による食中毒疾患の鑑別診断 differential diagnosis of microbial foodborne disease

Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure.

Alam S1, Javor S2, Degardin M2, Ajami D2, Rebek M2, Kissner TL1, Waag DM1, Rebek J Jr2, Saikh KU1.
Chemical biology & drug design.Chem Biol Drug Des.2015 Aug;86(2):200-9. doi: 10.1111/cbdd.12477. Epub 2014 Dec 8.
Both Gram-positive and Gram-negative pathogens or pathogen-derived components, such as staphylococcal enterotoxins (SEs) and endotoxin (LPS) exposure, activate MyD88-mediated pro-inflammatory cellular immunity for host defense. However, dysregulated MyD88-mediated signaling triggers exaggerated immu
PMID 25393063

Analysis and modeling of heat-labile enterotoxins of Escherichia coli suggests a novel space with insights into receptor preference.

Krishna Raja M1, Ghosh AR, Vino S, Sajitha Lulu S.
Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2015 Aug;33(8):1805-18. doi: 10.1080/07391102.2014.974073. Epub 2014 Nov 6.
Features of heat-labile enterotoxins of Escherichia coli which make them fit to use as novel receptors for antidiarrheals are not completely explored. Data-set of 14 different serovars of enterotoxigenic Escherichia coli producing heat-labile toxins were taken from NCBI Genbank database and used in
PMID 25375068

Current perspectivesin pathogenesis and antimicrobial resistance of enteroaggregative Escherichia coli.

Kong H1, Hong X2, Li X3.
Microbial pathogenesis.Microb Pathog.2015 Aug;85:44-9. doi: 10.1016/j.micpath.2015.06.002. Epub 2015 Jun 6.
Enteroaggregative Escherichia coli (EAEC) is an emerging pathogen that causes acute and persistent diarrhea in children and adults. While the pathogenic mechanisms of EAEC intestinal colonization have been uncovered (including bacterial adhesion, enterotoxin and cytotoxin secretion, and stimulation
PMID 26057827

Prevalent Phenotypic and Genotypic Profile of Enterotoxigenic Escherichia coli among Iranian Children

Nazarian Shahram,Gargari Seyed Latif Mousavi,Rasooli Iraj,Alerasol Masoome,Bagheri Samane,Alipoor Shakiba Darvish
Japanese Journal of Infectious Diseases 67(2), 78-85, 2014
… Enterotoxigenic Escherichia coli (ETEC) is the most common cause of diarrhea among children. … Heat-labile enterotoxin activity was confirmed using the Y1 adrenal cell assay, rabbit ileal loop and adenylate cyclase activation tests. …
NAID 130003399254

Nanoparticulated heat-stable (STa) and heat-labile B subunit (LTB)recombinant toxin improves vaccine protection against enterotoxigenic Escherichia coli challenge in mouse

DENG Guangcun,ZENG Jin,JIAN Minjie,LIU Wenmiao,ZHANG Zhong,LIU Xiaoming,WANG Yujiong
Journal of bioscience and bioengineering 115(2), 147-153, 2013-02-25
NAID 10031179889

Nanoparticulated heat-stable (STa) and heat-labile B subunit (LTB) recombinant toxin improves vaccine protection against enterotoxigenic Escherichia coli challenge in mouse(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)

Deng Guangcun,Zeng Jin,Jian Minjie [他],Liu Wenmiao,Zhang Zhong,Liu Xiaoming,Wang Yujiong
Journal of bioscience and bioengineering 115(2), 147-153, 2013-02
… Enterotoxigenic Escherichia coil (ETEC) remains a major cause of diarrheic disease in developing areas, for which there is no effective vaccine available. … In this study, we genetically engineered a recombinant heat-stable enterotoxin (STa) coupled to the subunit B of heat-labile enterotoxin (LTB). …
NAID 110009592562