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- 1. アレルギー性結膜炎：マネージメント allergic conjunctivitis management
- 2. アレルギー性鼻炎の薬物療法 pharmacotherapy of allergic rhinitis
English Journal
- The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase.
- Kim JL, Kang HN, Kang MH, Yoo YA, Kim JS, Choi CW.
- Acta haematologica.Acta Haematol.2011;126(4):241-5. doi: 10.1159/000330608. Epub 2011 Sep 27.
- PMID 21951998
- Contribution of mast cells to cerebral aneurysm formation.
- Ishibashi R, Aoki T, Nishimura M, Hashimoto N, Miyamoto S.Author information Department of Neurosurgery, Kyoto University, Graduate School of Medicine, Kyoto, Japan.AbstractCerebral aneurysm (CA) has a high prevalence and causes a fatal subarachnoid hemorrhage. Although CA is a socially important disease, there are currently no medical treatments for CA, except for surgical procedures, because the detailed mechanisms of CA formation remain unclear. From recent studies, we propose that CA is a chronic inflammatory disease of the arterial walls and various inflammation-related factors participate in its pathogenesis. Mast cells are well recognized as major inflammatory cells related to allergic inflammation. Mast cells have numerous cytoplasmic granules that contain various cytokines. Recent studies have revealed that mast cells contribute to various vascular diseases through degranulation and release of cytokines. In the present study, we examined the role of mast cells in the pathogenesis of CA using an experimental rat model. The number of mast cells was significantly increased in CA walls during CA formation. Inhibitors of mast cell degranulation effectively inhibited the size and medial thinning of induced CA through the inhibition of chronic inflammation, as evaluated by nuclear factor-kappa B activation, macrophage infiltration, and the expression of monocyte chemoattractant protein-1, matrix metalloproteinases (MMPs), and interleukin-1beta. Furthermore, an in vitro study revealed that the degranulation of mast cells induced the expression and activation of MMP-2, -9, and inducible nitric oxide synthase in primary cultured smooth muscle cells from rat intracranial arteries. These results suggest that mast cells contribute to the pathogenesis of CA through the induction of inflammation and that inhibitors of mast cell degranulation can be therapeutic drugs for CA.
- Current neurovascular research.Curr Neurovasc Res.2010 May;7(2):113-24.
- Cerebral aneurysm (CA) has a high prevalence and causes a fatal subarachnoid hemorrhage. Although CA is a socially important disease, there are currently no medical treatments for CA, except for surgical procedures, because the detailed mechanisms of CA formation remain unclear. From recent studies,
- PMID 20334612
- [Antihistamines in the treatment of allergic rhinitis--update 2008/2009].
- Kruszewski J.Author information Klinika Chorób Infekcyjnych i Alergologii, Wojskowy Instytut Medyczny w Warszawie.AbstractThe following paper reviews the latest news on antihistamines used in the treatment of allergic rhinitis. It describes the new results of investigations on clinical application of H3 and H4 receptors in therapy of allergic diseases as well as the effect of emedastine on histamine-induced tissue remodeling. Contemporary clinical research of these drugs fulfills the requirements of placebo-controlled trials, including the comparison with a reference drug, usually cetirizine. The paper discusses efficacy and safety of a new drug--bilastine, and the possibility to improve clinical outcome by combining antihistamine drugs with inhaled glucocorticosteroids and antileukotrienes. It also presents the studies on high efficacy of nasal antihistamines, which most probably results from their high concentration in inflamed tissue, as well as describes the latest news on safe use of antihistamines, including studies of fexofenadine enantiomers in drug interactions with P-glycoprotein, safety of a new antihistamine medication--rupatadine, and psychostimulating effect of some other antihistamines. The review shows that antihistamines, the most frequently used class of anti-allergy medications, have been constantly improved, which is of significant importance for progress of allergic diseases treatment.
- Otolaryngologia polska. The Polish otolaryngology.Otolaryngol Pol.2009 Sep;63(7):5-10. doi: 10.1016/S0030-6657(09)70180-5.
- The following paper reviews the latest news on antihistamines used in the treatment of allergic rhinitis. It describes the new results of investigations on clinical application of H3 and H4 receptors in therapy of allergic diseases as well as the effect of emedastine on histamine-induced tissue remo
- PMID 20564892
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