WordNet

the 4th letter of the Roman alphabet (同)d
copy that is not the original; something that has been copied (同)replication, reproduction

PrepTutorEJDIC

deuteriumの化学記号
(原作者が作った)原作の写し / 模写,複製(copy),模型
deoxyribonucleic acidディオキシリボ核酸

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/20 04:37:49」(JST)

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DNA-directed DNA polymerase (EC 2.7.7.7, DNA polymerase I, DNA polymerase II, DNA polymerase III, DNA polymerase alpha, DNA polymerase beta, DNA polymerase gamma, DNA nucleotidyltransferase (DNA-directed), DNA nucleotidyltransferase (DNA-directed), deoxyribonucleate nucleotidyltransferase, deoxynucleate polymerase, deoxyribonucleic acid duplicase, deoxyribonucleic acid polymerase, deoxyribonucleic duplicase, deoxyribonucleic polymerase, deoxyribonucleic polymerase I, DNA duplicase, DNA nucleotidyltransferase, DNA polymerase, DNA replicase, DNA-dependent DNA polymerase, duplicase, Klenow fragment, sequenase, Taq DNA polymerase, Taq Pol I, Tca DNA polymerase) is an enzyme with system name deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed).^[1]^[2]^[3]^[4]^[5]^[6] This enzyme catalyses the following chemical reaction

deoxynucleoside triphosphate + DNA_n diphosphate + DNA_n+1

Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time.

References

^ Bollum, F.J. (1960). "Calf thymus polymerase". J. Biol. Chem. 235: 2399–2403. PMID 13802334.
^ Falaschi, A. and Kornberg, A. (1966). "Biochemical studies of bacterial sporulation. II. Deoxy-ribonucleic acid polymerase in spores of Bacillus subtilis". J. Biol. Chem. 241: 1478–1482. PMID 4957767.
^ Lehman, I.R., Bessman, M.J., Simms, E.S. and Kornberg, A. (1958). "Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli". J. Biol. Chem. 233: 163–170. PMID 13563462.
^ Richardson, C.C., Schildkraut, C.L., Aposhian, H.V. and Kornberg, A. (1964). "Enzymatic synthesis of deoxyribonucleic acid. XIV. Further purification and properties of deoxyribonucleic acid polymerase of Escherichia coli". J. Biol. Chem. 239: 222–232. PMID 14114848.
^ Schachman, H.K., Adler, J., Radding, C.M., Lehman, I.R. and Kornberg, A. (1960). "Enzymatic synthesis of deoxyribonucleic acid. VII. Synthesis of a polymer of deoxyadenylate and deoxythymidylate". J. Biol. Chem. 235: 3242–3249. PMID 13747134.
^ Zimmerman, B.K. (1966). "Purification and properties of deoxyribonucleic acid polymerase from Micrococcus lysodeikticus". J. Biol. Chem. 241: 2035–2041. PMID 5946628.

External links

DNA-directed DNA polymerase at the US National Library of Medicine Medical Subject Headings (MeSH)

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Sindbis virus replicase-based DNA vaccine construct encoding FMDV-specific multivalent epitope gene: studies on its immune responses in guinea pigs.

Dar PA1, Ganesh K, Nagarajan G, Sarika S, Reddy GR, Suryanarayana VV.
Scandinavian journal of immunology.Scand J Immunol.2012 Oct;76(4):345-53. doi: 10.1111/j.1365-3083.2012.02733.x.
PMID 22702835

The DNA polymerase III holoenzyme contains γ and is not a trimeric polymerase.

Dohrmann PR1, Correa R2, Frisch RL2, Rosenberg SM2, McHenry CS3.
Nucleic acids research.Nucleic Acids Res.2016 Feb 18;44(3):1285-97. doi: 10.1093/nar/gkv1510. Epub 2016 Jan 18.
PMID 26786318

The β2 clamp in the Mycobacterium tuberculosis DNA polymerase III αβ2ε replicase promotes polymerization and reduces exonuclease activity.

Gu S1,2, Li W1, Zhang H1, Fleming J1, Yang W3, Wang S3, Wei W1, Zhou J4, Zhu G5, Deng J6, Hou J1, Zhou Y1, Lin S1,3, Zhang XE1, Bi L1.
Scientific reports.Sci Rep.2016 Jan 29;6:18418. doi: 10.1038/srep18418.
PMID 26822057

Japanese Journal

Isolation and characterization of a single-stranded DNA virus infecting the marine planktonic diatom Chaetoceros sp. (strain TG07-C28)

Plankton & benthos research 7(1), 20-28, 2012-02-01
NAID 10030123384

DNA polymerase γ, the mitochondrial replicase

Annu Rev Biochem 73, 293-320, 2004
NAID 30022173709

遺伝子組換えジャガイモ(NewLeaf Plus^【○!R】Potato)からの組換え遺伝子検知法の確立及びスナック菓子からの検知

食品衛生学雑誌 43(1), 24-29, 2002-02-25
NAID 10009307122

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DNA-directed DNA polymerase
Identifiers
EC number	2.7.7.7
CAS number	9012-90-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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PMC	articles
PubMed	articles
NCBI	proteins