DNA修復酵素
WordNet
- move, travel, or proceed toward some place; "He repaired to his cabin in the woods" (同)resort
- restore by replacing a part or putting together what is torn or broken; "She repaired her TV set"; "Repair my shoes please" (同)mend, fix, bushel, doctor, furbish up, restore, touch_on
- a formal way of referring to the condition of something; "the building was in good repair"
- the act of putting something in working order again (同)fix, fixing, fixture, mend, mending, reparation
- the 4th letter of the Roman alphabet (同)d
- any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
PrepTutorEJDIC
- …‘を'『修繕する』,修理する / …‘を'『償う』;…‘を'訂正する』 / …‘を'回復する / 修繕(修理)できる / 『修繕』,『修理』,修繕作業 / 〈U〉手入れ(修理)の状態
- (大挙して)(…へ)行く(GO)《+『to』+『名』》
- deuteriumの化学記号
- 酵素
- deoxyribonucleic acidディオキシリボ核酸
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/19 09:52:51」(JST)
[Wiki en表示]
DNA ligase (NAD+) |
Identifiers |
EC number |
6.5.1.2 |
CAS number |
37259-52-2 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
DNA ligase (NAD+) (EC 6.5.1.2, polydeoxyribonucleotide synthase (NAD+), polynucleotide ligase (NAD+), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme, deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, deoxyribonucleic acid joinase, DNA-joining enzyme, polynucleotide ligase (nicotinamide adenine dinucleotide)) is an enzyme with system name poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming).[1] This enzyme catalyses the following chemical reaction
- NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m
Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA.
References[edit]
- ^ Zimmerman, S.B., Little, J.W., Oshinsky, C.K. and Gellert, M. (1967). "Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide". Proc. Natl. Acad. Sci. USA 57: 1841–1848. PMID 4291949.
See also[edit]
External links[edit]
- DNA ligase (NAD ) at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Growth inhibition and antioxidative status induced by selenium-enriched broccoli extract and selenocompounds in DNA mismatch repair-deficient human colon cancer cells.
- Tsai CF, Ou BR, Liang YC, Yeh JY.SourceDepartment of Biotechnology, Asia University, Wu-Feng Chu, Taichung 413, Taiwan, ROC.
- Food chemistry.Food Chem.2013 Aug 15;139(1-4):267-73. doi: 10.1016/j.foodchem.2013.02.001. Epub 2013 Feb 10.
- The effects of enzymatic-digested Se-enriched broccoli extracts (SeB) and selenocompounds on growth and antioxidative status in human colon cancer cells was investigated in this study. HCT116 and HCT116+Chr.3 cells were treated with selenocompounds (sodium selenite, sodium selenate, Se-Met, MeSeCys)
- PMID 23561105
- Amyloid β peptides modify the expression of antioxidant repair enzymes and a potassium channel in the septohippocampal system.
- Durán-González J, Michi ED, Elorza B, Perez-Córdova MG, Pacheco-Otalora LF, Touhami A, Paulson P, Perry G, Murray IV, Colom LV.SourceCenter for Biomedical Studies, The University of Texas at Brownsville, Brownsville, TX, USA.
- Neurobiology of aging.Neurobiol Aging.2013 Aug;34(8):2071-6. doi: 10.1016/j.neurobiolaging.2013.02.005. Epub 2013 Mar 7.
- Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder characterized by extracellular accumulations of amyloid β (Aβ) peptides, intracellular accumulation of abnormal proteins, and early loss of basal forebrain neurons. Recent studies have indicated that the conformation of A�
- PMID 23473707
- Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan.
- Rothman SM, Mattson MP.SourceLaboratory of Neurosciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, United States. Electronic address: rothmansm@mail.nih.gov.
- Neuroscience.Neuroscience.2013 Jun 3;239:228-40. doi: 10.1016/j.neuroscience.2012.10.014. Epub 2012 Oct 16.
- During development of the nervous system, the formation of connections (synapses) between neurons is dependent upon electrical activity in those neurons, and neurotrophic factors produced by target cells play a pivotal role in such activity-dependent sculpting of the neural networks. A similar inter
- PMID 23079624
Japanese Journal
- Effect of lycopene on the blood-spinal cord barrier after spinal cord injury in mice
- Mechanical and oxidative stress in osteoarthritis
- The Journal of Physical Fitness and Sports Medicine 5(1), 81-86, 2016
- NAID 130005138399
- Downregulation of the DNA repair enzyme apurinic/apyrimidinic endonuclease 1 stimulates transforming growth factor-β1 production and promotes actin rearrangement.
- Biochemical and Biophysical Research Communications 461(1), 35-41, 2015-05-22
- NAID 120005757980
Related Links
- DNA damages can be recognized by enzymes, and, thus, they can be correctly repaired if redundant information, such as the undamaged sequence in the complementary DNA strand or in a homologous chromosome, is available for copying. ...
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- 英
- deoxyribonucleic acid
- 同
- デオキシリボ核酸
- 関
- リボ核酸 RNA