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- 1. 閉経期のホルモン療法で用いる製剤 preparations for menopausal hormone therapy
- 2. Functional hypothalamic amenorrhea: Evaluation and management
- 3. まれな先天性副腎過形成 uncommon congenital adrenal hyperplasias
- 4. 思春期における多嚢胞性卵巣症候群の診断的評価 diagnostic evaluation of polycystic ovary syndrome in adolescents
- 5. エストロゲン・プロゲスチン避妊剤の使用に関する概要 overview of the use of estrogen progestin contraceptives
English Journal
- Oral estrogen therapy may mitigate the effects of aerobic training on cardiorespiratory fitness in postmenopausal women: a double-blind, randomized clinical pilot study.
- Cardoso CG Jr1, Medina FL, Pinto LG, Oneda B, Costa LA, Labes E, Abrahão SB, Tinucci T, Mion D Jr, Fonseca AM, de Moraes Forjaz CL.Author information 1From the 1Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil; 2Center for Sport and Physical Education, State University of Londrina, Londrina, Brazil; and 3Gynecology and Climacteric Service and 4Hypertension Unit, General Hospital, University of São Paulo, São Paulo, Brazil.AbstractOBJECTIVE: The aim of this study was to evaluate the isolated and associated effects of oral estrogen therapy and aerobic training on cardiorespiratory fitness in postmenopausal women.
- Menopause (New York, N.Y.).Menopause.2014 Apr;21(4):376-82. doi: 10.1097/GME.0b013e31829e4a35.
- OBJECTIVE: The aim of this study was to evaluate the isolated and associated effects of oral estrogen therapy and aerobic training on cardiorespiratory fitness in postmenopausal women.METHODS: Forty-two hysterectomized healthy postmenopausal women were randomly divided (in a double-blind manner) int
- PMID 23942244
- Effects of estrogen therapy and aerobic training on sympathetic activity and hemodynamics in healthy postmenopausal women: a double-blind randomized trial.
- Oneda B1, Cardoso CG Jr, Forjaz CL, Araújo TG, Bernardo FR, de Gusmão JL, Pinto LG, Labes E, Abrahão SB, Mion D Jr, Fonseca AM, Tinucci T.Author information 1From the 1Hypertension Unit, General Hospital, and 2Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil; 3Center for Sport and Physical Education, State University of Londrina, Londrina, Brazil; and 4Gynecology and Climacteric Service, General Hospital, University of São Paulo, São Paulo, Brazil.AbstractOBJECTIVE: The aim of this study was to evaluate the isolated and associated effects of aerobic training and estrogen therapy on sympathetic nerve activity and hemodynamics in healthy postmenopausal women.
- Menopause (New York, N.Y.).Menopause.2014 Apr;21(4):369-75. doi: 10.1097/GME.0b013e31829d2a00.
- OBJECTIVE: The aim of this study was to evaluate the isolated and associated effects of aerobic training and estrogen therapy on sympathetic nerve activity and hemodynamics in healthy postmenopausal women.METHODS: Forty-five postmenopausal women (mean [SD] age, 51 [3] y) were randomly divided into f
- PMID 23899829
- Alterations in the estrogen environment of the testis contribute to declining sperm production in aging rats.
- Clarke M1, Pearl CA.Author information 1Department of Biological Sciences, Western Michigan University , Kalamazoo, MI , USA.AbstractAbstract Testicular function, specifically, production of testosterone by Leydig cells, diminishes during aging. Estradiol is also produced by the testis and potentially acts in an autocrine or paracrine manner to help regulate spermatogenesis. However, changes in estradiol concentration or receptor expression within the testis during aging remain unclear. This study was designed to test the hypothesis that the estrogen environment of the testis is altered during aging and that these changes are associated with declining sperm production. Sprague Dawley rats were examined at three, 15, 18, and 21 months of age to detail changes in sperm production and testicular concentration of testosterone and estradiol; five rats were used at three and 21 months and three rats were used at 15 and 18 months. Daily sperm production declined 49% from 15 to 21 months of age. Testicular concentrations of estradiol declined 53% from 15 to 21 months of age; testosterone concentrations were not significantly different. These results suggest that declines in intra-testicular estradiol may contribute to declining sperm production. We further tested our hypothesis by treating rats once every third day with a subcutaneous injection of estradiol valerate (1 µg/kg) from 15 to 18 months of age. Estradiol was increased 54% in treated animals while testosterone was unaffected. Estrogen receptor alpha (ESR1) expression was significantly reduced from 15 to 18 months and expression in estrogen-treated animals was significantly higher than age-matched controls. Additionally, ESR1 expression in 18 month treated animals was not different from 15 months of age. Importantly, daily sperm production in 18 month treated animals was 22% higher than age-matched controls; thus, treatment prevented approximately half of the decline observed in control animals. Collectively, our results suggest that estrogen is involved in maintaining optimum spermatogenesis in adult rats and that estrogen treatment may attenuate the age-associated loss in sperm production.
- Systems biology in reproductive medicine.Syst Biol Reprod Med.2014 Apr;60(2):89-97. doi: 10.3109/19396368.2014.885995. Epub 2014 Feb 5.
- Abstract Testicular function, specifically, production of testosterone by Leydig cells, diminishes during aging. Estradiol is also produced by the testis and potentially acts in an autocrine or paracrine manner to help regulate spermatogenesis. However, changes in estradiol concentration or receptor
- PMID 24499511
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