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a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"

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(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/18 17:50:48」(JST)

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The Currarino syndrome (also Currarino triad) is an inherited congenital disorder where (1) the sacrum (the fused vertebrae forming the back of the pelvis) is not formed properly, (2) there is a mass in the presacral space in front of the sacrum, and (3) there are malformations of the anus or rectum. It can also cause an anterior meningocele or a presacral teratoma.

Presacral teratoma usually is considered to be a variant of sacrococcygeal teratoma. However, the presacral teratoma that is characteristic of the Currarino syndrome may be a distinct kind.^[1]

Genetics

The disorder is an autosomal dominant genetic trait^[2] caused by a mutation in the HLXB9 homeobox gene. In 2000 the first large series of Currarino cases was genetically screened for HLXB9 mutations, and it was shown that the gene is specifically causative for the syndrome, but not for other forms of sacral agenesis. The study was published on the American Journal of Human Genetics.^[3]

Currarino syndrome has an autosomal dominant pattern of inheritance

References

^ Gopal M, Turnpenny PD, Spicer R (June 2007). "Hereditary sacrococcygeal teratoma--not the same as its sporadic counterpart!". Eur J Pediatr Surg 17 (3): 214–6. doi:10.1055/s-2007-965121. PMID 17638164.
^ Ashcraft KW, Holder TM (October 1974). "Hereditary presacral teratoma". J. Pediatr. Surg. 9 (5): 691–7. doi:10.1016/0022-3468(74)90107-9. PMID 4418917.
^ Belloni, E; Martucciello, G; Verderio, D; Ponti, E; Seri, M; Jasonni, V; Torre, M; Ferrari, M; Tsui, LC; Scherer, SW (January 2000). "Involvement of the HLXB9 homeobox gene in Currarino syndrome.". American Journal of Human Genetics 66 (1): 312–9. doi:10.1086/302723. PMC 1288336. PMID 10631160.

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1. 潜在性脊椎閉鎖不全症の病因およびタイプ pathogenesis and types of occult spinal dysraphism

English Journal

Radiological findings in Currarino syndrome.

Pérez Vega-Leal C, Sainz Gómez C, Ubis Rodríguez E, Garrido-Domínguez E, Díez Fernández A, Rubio Viguera V.SourceServicio de Radiología, Hospital San Pedro, Logroño, España.
Radiologia.Radiologia.2012 Jan 9. [Epub ahead of print]
OBJECTIVE: To describe the clinical, radiological and genetic findings of a family affected by Currarino syndrome (CS) (agenesis of the sacrum, presacral mass, and anal-rectal anomalies), and to familiarise the radiologist with this condition that, although uncommon, could be suspected by its charac
PMID 22237391

Presacral teratoma in a Curarrino syndrome woman with an unreported insertion in MNX1 gene.

Lin YH, Huang RL, Lai HC.SourceDepartment of Obstetrics and Gynecology, National Defense Medical Center, Taipei, Taiwan.
Taiwanese journal of obstetrics & gynecology.Taiwan J Obstet Gynecol.2011 Dec;50(4):512-4.
OBJECTIVE: Currarino syndrome (CS) comprises a presacral mass, anorectal malformation, and a sacral bony defect. It is rarely reported in the gynecological field.CASE REPORT: We describe here the case of a 26-year-old married woman with Currarino syndrome who presented with a presacral teratoma and
PMID 22212327

Japanese Journal

Clinical and genetic analysis of HLXB9 gene in Korean patients with Currarino syndrome

KIM In-Suk,OH Soo-young,CHOI Suk-Joo,KIM Jong-Hwa,PARK Kwan Hyun,PARK Hyun-Kyung,KIM Jong-Won,KI Chang-Seok
Journal of human genetics 52(8), 698-701, 2007-08-01
NAID 10019812977