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Antioxidant and tyrosinase inhibitory effects of neolignan glycosides from Crataegus pinnatifida seeds.

Huang XX1, Liu QB1, Wu J1, Yu LH1, Cong Q1, Zhang Y2, Lou LL1, Li LZ1, Song SJ1.
Planta medica.Planta Med.2014 Dec;80(18):1732-8. doi: 10.1055/s-0034-1383253. Epub 2014 Nov 6.
In our efforts to find an inhibitor of melanin formation and develop potential depigmenting agents for skin-protecting cosmetics and medicinal products from natural resources, we focused on the seeds of Crataegus pinnatifida which showed antioxidant and tyrosinase-inhibiting activities. By activity-
PMID 25377118

Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells.

Wei W1, Ying X, Zhang W, Chen Y, Leng A, Jiang C, Liu J.
The Journal of pharmacy and pharmacology.J Pharm Pharmacol.2014 Jul;66(7):988-97. doi: 10.1111/jphp.12225. Epub 2014 Feb 17.
OBJECTIVES: Vitexin-2"-O-rhamnoside (VOR) and vitexin-4"-O-glucoside (VOG) are the two main flavonoid glycosides of the leaves of Cratagus pinnatifida Bge. var. major N. E. Br. that has been widely used for the treatment of cardiovascular system diseases. In this study, we simultaneously investi
PMID 24533889

Hepatic and gastrointestinal first-pass effects of vitexin-4″-O-glucoside in rats.

Chen Y1, Zhang W, Li D, Ai J, Meng Y, Ying X, Kang T.
The Journal of pharmacy and pharmacology.J Pharm Pharmacol.2013 Oct;65(10):1500-7. doi: 10.1111/jphp.12121. Epub 2013 Jul 30.
OBJECTIVES: This paper was to clarify the reasons of low bioavailability of vitexin-4″-O-glucoside (VOG) in rats via hepatic combined with gastrointestinal first-pass effect.METHODS: Observed the hepatic first-pass effect through the comparison of area under the plasma concentration-time curve fro
PMID 24028617