Campylobacter enteritis

カンピロバクター腸炎

WordNet

1. inflammation of the intestine (especially the small intestine); usually characterized by diarrhea

PrepTutorEJDIC

1. 腸炎

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/10/01 07:59:45」(JST)

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Campylobacter
Classification and external resources
Specialty	Infectious disease
ICD-10	A04.5
ICD-9-CM	008.43
DiseasesDB	1914
MedlinePlus	000224
eMedicine	ped/2697 med/263
MeSH	D002169

Campylobacteriosis is an infection by the Campylobacter bacterium, most commonly C. jejuni. It is among the most common bacterial infections of humans, often a foodborne illness. It produces an inflammatory, sometimes bloody, diarrhea or dysentery syndrome, mostly including cramps, fever and pain.

Cause

Main article: Campylobacter

Campylobacter bacteria are the number-one cause of food-related gastrointestinal illness in the United States. This scanning electron microscope image shows the characteristic spiral, or corkscrew, shape of C. jejuni cells and related structures.

Campylobacteriosis is caused by Campylobacter bacteria (curved or spiral, motile, non–spore-forming, Gram-negative rods). The disease is usually caused by C. jejuni, a spiral and comma shaped bacterium normally found in cattle, swine, and birds, where it is nonpathogenic, but the illness can also be caused by C. coli (also found in cattle, swine, and birds), C. upsaliensis (found in cats and dogs) and C. lari (present in seabirds in particular).

One effect of campylobacteriosis is tissue injury in the gut. The sites of tissue injury include the jejunum, the ileum, and the colon. C jejuni appears to achieve this by invading and destroying epithelial cells.

C. jejuni can also cause a latent autoimmune effect on the nerves of the legs, which is usually seen several weeks after a surgical procedure of the abdomen. The effect is known as an acute idiopathic demyelinating polyneuropathy (AIDP), i.e. Guillain–Barré syndrome, in which one sees symptoms of ascending paralysis, dysaesthesias usually below the waist, and, in the later stages, respiratory failure.

Some strains of C jejuni produce a cholera-like enterotoxin, which is important in the watery diarrhea observed in infections. The organism produces diffuse, bloody, edematous, and exudative enteritis. In a small number of cases, the infection may be associated with hemolytic uremic syndrome and thrombotic thrombocytopenic purpura through a poorly understood mechanism.

Transmission

The common routes of transmission for the disease-causing bacteria are fecal-oral, person-to-person sexual contact, ingestion of contaminated food (generally unpasteurized (raw) milk and undercooked or poorly handled poultry), and waterborne (i.e., through contaminated drinking water). Contact with contaminated poultry, livestock, or household pets, especially puppies, can also cause disease.

Animals farmed for meat are the main source of campylobacteriosis. A study published in PLoS Genetics (September 26, 2008) by researchers from Lancashire, England, and Chicago, Illinois, found that 97 percent of campylobacteriosis cases sampled in Lancashire were caused by bacteria typically found in chicken and livestock. In 57 percent of cases, the bacteria could be traced to chicken, and in 35 percent to cattle. Wild animal and environmental sources were accountable for just three percent of disease.

The infectious dose is 1000–10,000 bacteria (although ten to five hundred bacteria can be enough to infect humans). Campylobacter species are sensitive to hydrochloric acid in the stomach, and acid reduction treatment can reduce the amount of inoculum needed to cause disease.

Exposure to bacteria is often more common during travelling, and therefore campylobacteriosis is a common form of travelers' diarrhea.

Epidemiology

Campylobacter is one of the most common causes of human bacterial gastroenteritis. For instance, an estimated 2 million cases of Campylobacter enteritis occur annually in the U.S., accounting for 5–7% of cases of gastroenteritis. Furthermore, in the United Kingdom during 2000, Campylobacter jejuni was involved in 77.3% in all cases of laboratory confirmed foodborne illness. About 15 of every 100,000 people are diagnosed with campylobacteriosis every year, and with many cases going unreported, up to 0.5% of the general population may unknowingly harbor Campylobacter in their gut.

A large animal reservoir is present as well, with up to 100% of poultry, including chickens, turkeys, and waterfowl, having asymptomatic infections in their intestinal tracts. Infected chicken feces may contain up to 10⁹ bacteria per 25 grams, and due to the installations, the bacteria are rapidly spread to other chickens. This vastly exceeds the infectious dose of 1000–10,000 bacteria for humans.

In January 2013, the UK's Food Standards Agency warned that two-thirds of all raw chicken bought from UK shops was contaminated with campylobacter, affecting an estimated half a million people annually and killing approximately 100.

Symptoms

The prodromal symptoms are fever, headache, and myalgia, which can be severe, lasting as long as 24 hours. After 1–5 days, typically, these are followed by diarrhea (as many as 10 watery, frequently bloody, bowel movements per day) or dysentery, cramps, abdominal pain, and fever as high as 40 °C (104 °F). In most people, the illness lasts for 2–10 days. It is classified as invasive/inflammatory diarrhea, also described as bloody diarrhea or dysentery.

There are other diseases showing similar symptoms. For instance, abdominal pain and tenderness may be very localized, mimicking acute appendicitis. Furthermore, Helicobacter pylori is closely related to Campylobacter and causes peptic ulcer disease.

Other factors

In patients with HIV, infections may be more frequent, may cause prolonged bouts of dirty brown diarrhea, and may be more commonly associated with bacteremia and antibiotic resistance. In participants of unprotected anal intercourse, campylobacteriosis is more localized to the distal end of the colon and may be termed a proctocolitis. The severity and persistence of infection in patients with AIDS and hypogammaglobulinemia indicates that both cell-mediated and humoral immunity are important in preventing and terminating infection.

Diagnosis

Campylobacter organisms can be detected by performing a Gram stain of a stool sample with high specificity and a sensitivity of ~60%, but are most often diagnosed by stool culture. Fecal leukocytes should be present and indicate the diarrhea to be inflammatory in nature. Methods currently being developed to detect the presence of campylobacter organisms include antigen testing via an EIA or PCR.

Treatment

The infection is usually self-limiting, and in most cases, symptomatic treatment by liquid and electrolyte replacement is enough in human infections.

Antibiotics

Antibiotic treatment only has a marginal effect on the duration of symptoms, and its use is not recommended except in high-risk patients with clinical complications.

Erythromycin can be used in children, and tetracycline in adults. Some studies show, however, that erythromycin rapidly eliminates Campylobacter from the stool without affecting the duration of illness. Nevertheless, children with dysentery due to C. jejuni benefit from early treatment with erythromycin. Treatment with antibiotics, therefore, depends on the severity of symptoms. Quinolones are effective if the organism is sensitive, but high rates of quinolone use in livestock means that quinolones are now largely ineffective.

Antimotility agents, such as loperamide, can lead to prolonged illness or intestinal perforation in any invasive diarrhea, and should be avoided. Trimethoprim/sulfamethoxazole and ampicillin are ineffective against Campylobacter.

In animals

In the past, poultry infections were often treated by mass administration of enrofloxacin and sarafloxacin for single instances of infection. The FDA banned this practice, as it promoted the development of fluoroquinolone-resistant populations. A major broad-spectrum fluoroquinolone used in humans is ciprofloxacin.

Currently growing resistance of the Campylobacter to fluoroquinolones and macrolides is of a major concern.

Prognosis

Campylobacteriosis is usually self-limited without any mortality (assuming proper hydration is maintained). However, there are several possible complications.

Complications

Complications include toxic megacolon, dehydration and sepsis. Such complications generally occur in young children (< 1 year of age) and immunocompromised people. A chronic course of the disease is possible; this disease process is likely to develop without a distinct acute phase. Chronic campylobacteriosis features a long period of sub-febrile temperature and asthenia; eye damage, arthritis, endocarditis may develop if infection is untreated.

Occasional deaths occur in young, previously healthy individuals because of blood volume depletion (due to dehydration), and in persons who are elderly or immunocompromised.

Some individuals (1–2 in 100,000 cases) develop Guillain–Barré syndrome, in which the nerves that join the spinal cord and brain to the rest of the body are damaged, sometimes permanently. This occurs only with infection of C. jejuni and C. upsaliensis.

Prevention

• Pasteurization of milk and chlorination of drinking water destroy the organism.
• Treatment with antibiotics can reduce fecal excretion.
• Infected health care workers should not provide direct patient care.
• Separate cutting boards should be used for foods of animal origin and other foods. After preparing raw food of animal origin, all cutting boards and countertops should be carefully cleaned with soap and hot water.
• Contact with pet saliva and feces should be avoided.

The World Health Organization recommends the following:

• Food should be properly cooked and hot when served.
• Consume only pasteurized or boiled milk and milk products, never raw milk products.
• Make sure that ice is from safe water.
• If you are not sure of the safety of drinking water, boil it, or disinfect it with chemical disinfectant.
• Wash hands thoroughly and frequently with soap, especially after using the toilet and after contact with pets and farm animals.
• Wash fruits and vegetables thoroughly, especially if they are to be eaten raw. Peel fruits and vegetables whenever possible.
• Food handlers, professionals and at home, should observe hygienic rules during food preparation.
• Professional food handlers should immediately report to their employer any fever, diarrhea, vomiting or visible infected skin lesions.

See also

• Campylobacter
• enteritis
• gastroenteritis

External links

• Campylobacter jejuni genomes and related information at PATRIC, a Bioinformatics Resource Center funded by NIAID

UpToDate Contents

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• 1. カンピロバクター感染症の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of campylobacter infection
• 2. カンピロバクター感染の微生物学、病因、および疫学 microbiology pathogenesis and epidemiology of campylobacter infection
• 3. 一般的ではないカンピロバクター種および関連細菌の感染 infection with less common campylobacter species and related bacteria
• 4. ギラン・バレー症候群の病因 pathogenesis of guillain barre syndrome
• 5. 猫からの人畜共通感染症 zoonoses from cats

English Journal

• Individual Restriction Of Fine Specificity Variability In Anti-GM1 IgG Antibodies Associated With Guillain-Barré Syndrome.

• Lardone RD1, Yuki N2, Irazoqui FJ1, Nores GA1.
• Scientific reports.Sci Rep.2016 Jan 28;6:19901. doi: 10.1038/srep19901.
• Elevated titers of serum antibodies against GM1 ganglioside are associated with a variety of autoimmune neuropathies. Much evidence indicates these autoantibodies play a primary role in the disease processes, but the mechanism for their appearance is unclear. We studied the fine specificity of anti-
• PMID 26818965

• Role of matrix metalloproteinases in the pathogenesis of childhood gastroenteritis.

• Kawamura Y1, Gotoh K2, Takeuchi N1, Miura H1, Nishimura N2, Ozaki T2, Yoshikawa T1.
• Journal of medical virology.J Med Virol.2016 Jan 13. doi: 10.1002/jmv.24473. [Epub ahead of print]
• Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been implicated in the pathogenesis of gastrointestinal diseases, such as rotavirus gastroenteritis (GE). Kinetics of these biomarkers were examined in paired serum samples collected from bacterial enteritis pa
• PMID 26765397

• Composition of human faecal microbiota in resistance to Campylobacter infection.

• Kampmann C1, Dicksved J2, Engstrand L3, Rautelin H4.
• Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect.2016 Jan;22(1):61.e1-8. doi: 10.1016/j.cmi.2015.09.004. Epub 2015 Sep 11.
• In mice, specific species composition of gut microbiota enhances susceptibility to Campylobacter jejuni but little is known about the specific composition of the human gut microbiota in providing protection from infections caused by enteropathogens. Healthy adult individuals, who travelled in groups
• PMID 26369602

Japanese Journal

• Guillain–Barré syndrome and anti-ganglioside antibodies: a clinician-scientist's journey

• YUKI Nobuhiro
• Proceedings of the Japan Academy, Series B 88(7), 299-326, 2012
• … Along with several colleagues, we identified IgG autoantibodies against ganglioside GM1 in two patients with GBS subsequent to Campylobacter jejuni enteritis. …
• NAID 130001924752

• 臨床研究・症例報告 小児カンピロバクター陽炎150例の臨床的検討

• 前山 昌隆,石田 允
• 小児科臨床 64(9), 2011-2015, 2011-09
• NAID 40018941449

• キャンピロバクター腸炎39例の臨床的検討

• 小篠 洋之,荒木 靖三,野明 俊裕,藤 勇二,中川 元典,岩谷 泰江,鍋山 健太郎,豊永 敬之,高野 正博,白水 和雄
• 日本大腸肛門病学会雑誌 64(2), 67-72, 2011-02-01
• 目的：キャンピロバクター腸炎の臨床的特徴を明らかにするためにretrospectiveに検討した．対象と方法：2007年1月から2008年12月までに便培養検査でキャンピロバクター腸炎と診断した39例．成績：男性24例，女性15例，平均年齢は35.9歳．発生時期は4月から6月に多く，鶏肉関連食品の摂取既往があったのは7例であった．下痢はほとんどの症例に認められ，大腸内視鏡では点状発赤（73～75％ …
• NAID 10029094986

Related Links

• Campylobacter infection: MedlinePlus Medical Encyclopedia

Campylobacter enteritis is a common cause of intestinal infection. These bacteria are also one of the many causes of traveler's diarrhea or food poisoning. People most often get infected by eating or drinking food or water ...

• Campylobacter enteritis. - National Center for Biotechnology ...

Abstract Campylobacter jejuni/coli has recently become recognized as a common bacterial cause of diarrhea. Infection can occur at any age. The usual incubation period of campylobacter enteritis is 2 to 5 days. Fever ...

Related Pictures

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★リンクテーブル★

リンク元	「カンピロバクター腸炎」
関連記事	「Campylobacter」

「カンピロバクター腸炎」

　　[★]

英

Campylobacter enteritis

関

カンピロバクター属、食中毒菌

病原体

• Campylobacter jejuni
• Campylobacter coli

疫学

• 4-5歳児が最多

症状

• 腹痛、下痢(水様便、時に血便)、嘔吐などの胃腸炎を呈する。

参考

• 1. [charged] カンピロバクター感染の微生物学、病因、および疫学 - uptodate [1]
• 2. [charged] カンピロバクター感染の臨床症状、診断、治療 - uptodate [2]

「Campylobacter」

　　[★] カンピロバクター属